Isobolographic analysis of the antinociceptive interactions between ketoprofen and paracetamol

Qiu, Hai-Xia; Liu, Jin; Kong, Hui; Liu, Yan; Mei, Xingguo

doi:10.1016/j.ejphar.2006.11.017

Cited by 23 publications

(19 citation statements)

References 39 publications

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“…ketoprofen, dexketoprofen (Miranda et al 2006(Miranda et al , 2007Luccarini et al 2006;Seideman 1993;Schug 2006;Qiu et al 2007). The synergic interaction was observed in the two nociceptive tests and, on the basis of the interaction indexes (Table 2), was stronger in Phase I of the formalin orofacial test.…”

Section: Discussionmentioning

confidence: 99%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

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Section: Discussionmentioning

confidence: 99%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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“…Hayes et al 13 used telemetry-derived locomotor activity to assess the analgesic efficacy of paracetamol administered in drinking water. They showed the marked reduction in water consumption that occurred postoperatively resulted in estimated consumptions of approximately 64 mg/kg of paracetamol over 24 h. This is well below the ED for paracetamol in antinociceptive tests, 4,11,14 and may account for the lack of efficacy. However, the present study suggests that, even at doses that would be predicted to be effective, paracetamol is unable to provide sufficient postsurgical analgesia to significantly reduce the behavioural effects of vasectomy surgery.…”

Section: Discussionmentioning

confidence: 99%

“…It is currently considered to be a selective COX-3 inhibitor 2 and also shows weak antiinflammatory activity 3 although the exact mode of action is still unclear. It has a plasma half-life of 52 -98 min, 4 and when administered orally peak plasma concentrations are found after 120 min in mice. 4 A previous study has shown orally administered paracetamol to have profound analgesic effects on bone cancer pain in mice when administered alone and when administered with a subanalgesic dose of morphine.…”

mentioning

confidence: 99%

“…It has a plasma half-life of 52 -98 min, 4 and when administered orally peak plasma concentrations are found after 120 min in mice. 4 A previous study has shown orally administered paracetamol to have profound analgesic effects on bone cancer pain in mice when administered alone and when administered with a subanalgesic dose of morphine. 2 It may therefore represent a useful addition to the range of agents that could be used to prevent postprocedural pain in mice.…”

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confidence: 99%

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The analgesic effects of oral paracetamol in two strains of mice undergoing vasectomy

2009

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As the production of transgenic mice increases, the need for vasectomized mice also increases. Currently, there is no accurate method of identifying pain in these mice which can be used routinely and therefore no acceptable analgesic regimens can be established. Sixteen male CBA/CaCrl and 16 male DBA/2JCrl mice were randomly allocated to one of four treatment groups (saline, low, medium and high dose oral paracetamol) and then underwent abdominal vasectomy. Their behaviour was videotaped (filmed) preoperatively and at one hour postoperatively and the data were analysed using an automated system -HomeCageScan. HomeCageScan detected significant changes in 16 behaviours following vasectomy. Such behaviours included twitching, rearing and grooming with varying levels of significance between the strains. No significant effects of drug treatment in any of the behaviours analysed by HomeCageScan were detected in the postoperative observation period. Strain-specific changes do occur in behaviour following abdominal vasectomy and HomeCageScan is capable of detecting these changes. The use of orally administered paracetamol was deemed to be an ineffective analgesic for CBA/CaCrl and DBA/2JCrl mice undergoing vasectomy.

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“…Miranda et al [68], using the mouse abdominal constriction test, showed the values for ED50 (effective dose to produce 50% antinociception) calculated from log dose-response curves of fixed ratio combinations of paracetamol with various NSAIDs were significantly smaller than those calculated theoretically. A more recent study has found similar synergism between paracetamol and the NSAID ketoprofen [69], but there is only limited evidence that this interaction is advantageous in the clinical setting. Two systematic reviews have produced conflicting data; both found the addition of an NSAID to paracetamol improved postoperative analgesia compared with paracetamol alone, but while Hyllested et al [63] found adding paracetamol to an NSAID was associated with a small increase in analgesic efficacy, Romsing et al [70] found no evidence of benefit.…”

Section: Drug Interactionsmentioning

confidence: 98%