Isoantigens Abh in Bladder Tumors as an Indicator of Malignant Potential

Invasiveness of transformed bladder epithelial cells

“…The absence of ABO(H) surface antigens in TCC has been observed by many authors (see 62), most of whom have used the specific red cell adherence (SRCA) test (63)(64)(65)(66)(67)(68)(69)(70)(71), the immunoperoxidase test (72)(73)(74)(75) or immunofluorescent techniques (76)(77)(78). SRCA has been shown to produce false positive results in patients who have received radiotherapy or thiotepa for their bladder tumor, and false negative results in patients with type 0 blood (70,72,73).…”

“…The correlation between the absence of blood group surface antigens and poor prognosis with a high rate of invasive recurrence of low grade superficial tumors has been described by several authors (64,65,68,69,71,72,(74)(75)(76)(77)(79)(80)(81). The basis for this association is not well understood, and a more detailed study of the correlation between antigenic deletion and immunological host response as well as additional immunological, histochemical and ultrastructural signs of dedifferentiation are needed.…”