Isoantibodies to inherited types of β-lipoproteins (Ag) and immunoglobulins (Gm and Inv)

Vierucci, A; Blumberg, Baruch S.; Dettori, M; Borgatti, L; Levene, C.

doi:10.1016/s0022-3476(68)80429-9

Cited by 21 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allen and Kunkel [3] reported an incidence of near 60%, which is in good agreement with our results. A lower incidence has been observed in a group of Italian patients [18,19] ; in this series a direct correlation was noticed between the number of transfusions and the incidence of antibodies; a similar relation was not observed in our patients. more important role than the total Blumberg et al [7] detected anti-Ag precipitine in 13 of 36 patients with thalassaemia who had received more than 50 transfusions.…”

supporting

confidence: 53%

See 1 more Smart Citation

Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

Economidou¹,

Constantoulakis²,

Augoustaki³

et al. 1971

Vox Sanguinis

View full text Add to dashboard Cite

supporting

confidence: 53%

“…In the group of thalassaemics studied in the United States splenectomy was performed less fre quently than in the Italian group. According to Vierucci et al [19] there is a reduction of anti-Gm and anti-Ag after splenectomy.…”

mentioning

confidence: 97%

Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

Economidou¹,

Constantoulakis²,

Augoustaki³

et al. 1971

Vox Sanguinis

View full text Add to dashboard Cite

“…The same observations were ap plicable in patients in whom specially severe reactions were noted. In these patients, 8 were positive by LCT while a significantly larger number of 14 were positive using LCT-B (p<0.01). Table III compares the number of posi tive reactions obtained in the pre-and post transfusion specimens of the reactors when tested on the expanded lymphocyte panel.…”

Section: Resultsmentioning

confidence: 85%

An Investigation of Nonhemolytic Transfusion Reactions

Decary¹,

Ferner²,

Giavedoni³

et al. 1984

Vox Sanguinis

View full text Add to dashboard Cite

This study was undertaken to document the incidence of immediate, nonhemolytic transfusion reactions and to identify a technique or set of techniques that would best identify the different causes of these reactions. A variety of tests were employed to detect lymphocyte, granulocyte, platelet and anti-IgA antibodies. During this study 26,318 units of blood components were transfused on 5,030 occasions. 191 immediate, nonhemolytic reactions were experienced giving an incidence per unit of 0.73%. Blood specimens from 101 of these patients were investigated along with serum from 57 patients who showed no reaction to transfusion as controls. We show that standard B cell lymphocytotoxicity testing is the technique with which most antibodies can be detected (64% of reactors positive vs. 30% of controls, p< 0.001). Additional tests did not significantly increase the level of antibody detection.

show abstract

“…These are directed against antigens of blood cells, serum proteins, various bacteria and viruses. The incidence of some of these antibodies has been investigated by several workers [VIERUCCI, 1965;ALLEN and KUNKEL, 1966;VIERUCCI et al, 1968;ECONOMIDOU et This work was supported in part by a National Research Institute grant.…”

Section: Introductionmentioning

confidence: 99%

Complement Levels in Relation to Certain Antibodies in Polytransfused Thalassaemic Patients

Economidou¹,

Pathouli²,

Constantoulakis³

et al. 1976

Vox Sanguinis

View full text Add to dashboard Cite

Polytransfused patients are exposed to a variety of antigenic stimuli which may eventually trigger autoimmune reactions. The relation of serum complement to the occurrence of various antibodies has been investigated in a group of 75 polytransfused thalassaemic patients. The incidence of the antibodies studied was as follows: anti-HBs 77%, anti-Gm 64%, rheumatoid factor 31%, antinuclear 13%, anti-smooth muscle 47%. Anti-parietal cell, anti-thyroid and anti-kidney were only rarely found and antimitochondrial antibodies were never detected. Total hemolytic complement was low in 6 and incidentally decreased in 21 patients. A positive correlation was found between low serum complement and presence of rheumatoid factor. The high incidence of anti-smooth muscle antibodies seems to be unrelated to liver disease.

show abstract

Isoantibodies to inherited types of β-lipoproteins (Ag) and immunoglobulins (Gm and Inv)

Cited by 21 publications

References 30 publications

Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

An Investigation of Nonhemolytic Transfusion Reactions

Complement Levels in Relation to Certain Antibodies in Polytransfused Thalassaemic Patients

Contact Info

Product

Resources

About