Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy

Mo, Hualong; Liu, Jie-Ying; Su, Zhengxi; Zhao, Deng‐Gao; Ma, Yanyan; Zhang, Kun; Wang, Qi; Fu, Chun; Wang, Yao; Chen, Meiwan; Hu, Burong

doi:10.1016/j.ejmech.2024.116765

Cited by 2 publications

(2 citation statements)

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“…Many other lactones have antitumor activities, including alantolactone which shows almost similar activities against many tumors as ISA ( Liu X. et al, 2021 ; Wang, 2021 ). Many derivatives of ISA have been synthesize and their antitumor effects were tested in various kinds of tumors ( Anikina et al, 2018 ; Kumar et al, 2016 ; Mo et al, 2024 ; Semakov et al, 2018 ). Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3αR,4αR,6R,8αR, 9αR)-8α-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K ), the IC 50 of which against the cancer cell lines were below 0.3 μM ( Mo et al, 2024 ).…”

Section: Antitumor Activitymentioning

confidence: 99%

“…Many derivatives of ISA have been synthesize and their antitumor effects were tested in various kinds of tumors ( Anikina et al, 2018 ; Kumar et al, 2016 ; Mo et al, 2024 ; Semakov et al, 2018 ). Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3αR,4αR,6R,8αR, 9αR)-8α-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K ), the IC 50 of which against the cancer cell lines were below 0.3 μM ( Mo et al, 2024 ). The nanoparticles of this compound are more potent against these cancer cells, and the best IC 50 is reported to be 0.023 μM against HCT-116 cells ( Mo et al, 2024 ).…”

Section: Antitumor Activitymentioning

confidence: 99%

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Isoalantolactone: a review on its pharmacological effects

Yang

2024

Front. Pharmacol.

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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