Abstract.We review the characteristics of nucleosynthesis and radioactivities in 'Hypernovae', i.e., supernovae with very large explosion energies ( ∼ > 10 52 ergs) and their γ-ray line signatures. We also discuss the 44 Ti line γ-rays from SN1987A and the detectability with INTEGRAL. Signatures of hypernova nucleosynthesis are seen in the large [(Ti, Zn)/Fe] ratios in very metal poor stars. Radioactivities in hypernovae compared to those of ordinary core-collapse supernovae show the following characteristics: 1) The complete Si burning region is more extended, so that the ejected mass of 56 Ni can be much larger. 2) Si-burning takes place in higher entropy and more α-rich environment. Thus the 44 Ti abundance relative to 56 Ni is much larger. In aspherical explosions, 44 Ti is even more abundant and ejected with velocities as high as ∼ 15,000 km s −1 , which could be observed in γ-ray line profiles.3) The abundance of 26 Al is not so sensitive to the explosion energy, while the 60 Fe abundance is enhanced by a factor of ∼ 3.