Islet of Langerhans heterotopia in Meckel’s diverticulum

Arnold, C C; Marjoniemi, Veli

doi:10.1080/00313020600924559

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…[4][5][6][7] This paucity of information hampers a clear delineation of the clinical and pathological characteristics of these endocrine tumors and, in turn, makes it difficult to assess the best strategy for therapeutic management and follow-up. To date, several important issues remain controversial, including the following: (a) is there any relation between endocrine tumorigenesis and the possible occurrence of ectopic gastric and pancreatic tissues in Meckel's diverticulum 1,8 as suggested by some authors? 9 (b) Are endocrine tumors of Meckel's diverticulum more similar to appendiceal tumors as suggested by some reports, 10 or to ileal tumors as suggested by more recent analyses?…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases

Poncet

Hervieu

Walter

et al. 2011

Journal of Gastrointestinal Surgery

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Section: Introductionmentioning

confidence: 99%

Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases

Poncet

Hervieu

Walter

et al. 2011

Journal of Gastrointestinal Surgery

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“…Diagnosis of this entity can be difficult due it’s rarity and because it must be distinguished from a well-differentiated neuroendocrine tumor. To our knowledge, only 5 cases of pancreatic endocrine-only heterotopia have been previously reported and only 3 cases in the English language literature (2 cases within Meckel’s diverticula 11,12 and 1 case in the stomach 13 ; Table 1). Differentiating pancreatic endocrine heterotopia from a well-differentiated neuroendocrine tumor is important because the entities have different prognosis and treatment.…”

Section: Discussionmentioning

confidence: 98%

Pancreatic Endocrine Heterotopia Involving Meckel’s Diverticulum: A Potential Mimic of Neuroendocrine Tumor

2020

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Pancreatic heterotopia most commonly occurs in the upper gastrointestinal tract, but can occur in other sites, including Meckel’s diverticulum. When multiple histologic elements of the pancreatic tissue (acini, ducts, and endocrine cells) are present, the diagnosis is typically straightforward. In this article, we report a rare case of pure endocrine pancreatic heterotopia involving a Meckel’s diverticulum, a potential mimic of a well-differentiated neuroendocrine tumor. Several features were useful in making the distinction, including lack of desmoplasia and mass forming lesion, and immunohistochemical staining in a physiological pattern similar to that of islets of Langerhans. It is important for pathologists to be aware of this entity and its features to avoid misdiagnosis of a neuroendocrine tumor.

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“…It has an incidence of approximately 1 in 5 million and a mean survival of 5 to 10 months. 1 Typical features of this disease include late stage presentation before the age of 12 months, a kidney tumour with characteristic rhabdoid features on histology, an underlying SMARCB1 or SMARCA4 mutation and a very poor prognosis regardless of treatment modality. We present a very recent and classic case of a very uncommon tumour and discuss the most recent understanding of the driver mutations and associated rhabdoid tumour predisposition syndrome.…”

Section: Malignant Sft With Nodal Metastasis a Case Reportmentioning

confidence: 99%