Islet Cell Tumor of the Pancreas: Biphasic CT versus MR Imaging in Tumor Detection

Ichikawa, Tomoaki; Peterson, Mark S.; Federle, Michael P.; Baron, Richard L.; Haradome, Hiroki; Kawamori, Yasuhiro; Nakamura, Shigeru; Araki, Tsutomu

doi:10.1148/radiology.216.1.r00jl26163

Cited by 253 publications

(110 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a comparison study between MRI and CT as well as angiography for detection of metastatic lesions, MRI was shown to be superior [31] . As with CT, multiphasic CE MRI is recommended, with fat-suppressed CE T1-weighted (T1W) imaging providing the best accuracy, with an area under the receiveroperating curve (AUROC) of 0.98 [32] . This has been corroborated by a more recent study by Herwick et al [33] .…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging of gastroenteropancreatic neuroendocrine tumors

Tan

Tan²

2011

WJCO

View full text Add to dashboard Cite

Imaging of gastroenteropancreatic neuroendocrine tumors can be broadly divided into anatomic and functional techniques. Anatomic imaging determines the local extent of the primary lesion, providing crucial information required for surgical planning. Functional imaging, not only determines the extent of metastatic disease spread, but also provides important information with regard to the biologic behavior of the tumor, allowing clinicians to decide on the most appropriate forms of treatment. We review the current literature on this subject, with emphasis on the strengths of each imaging modality.

show abstract

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging of gastroenteropancreatic neuroendocrine tumors

Tan

Tan²

2011

WJCO

View full text Add to dashboard Cite

show abstract

“…An improvement in MRI technique is the use of diffusion weighted MRI (DWI-MRI) for abdominal imaging. DWI is an MRI technique that detects changes in the molecular diffusion of water in biologic tissues and the valuable role of DWI in the detection of pancreatic tumors has been reported in several studies (Figure 4a,4b & 5) [33][34][35][36].…”

Section: Mrimentioning

confidence: 99%

Insulinoma: Literature’s Review (2)

AlJadir¹

2015

EMIJ

View full text Add to dashboard Cite

“…We believe, however, that their sensitivities are similar and exceed 80%. 8 CT and MRI have the advantage of the detection of small liver metastases although they may be difficult to identify on contrast-enhanced CT and gadoliniumenhanced MRI. 9 The use of liver-specific contrast agents such as mangafodipir-DPDP may improve their detection.…”

Section: Neuroendocrine Tumoursmentioning

confidence: 99%

“…3 Genetic studies have also defined new and clinically distinct endocrine neoplasia syndromes, for example: several familial paraganglioma syndromes resulting from mutations in the succinate dehydrogenase subunit genes [4][5][6] ; multiple endocrine neoplasia type 4, 7 and hyperparathyroidism-jaw tumour syndrome. 8 As a rule, genetic testing and interpretation of the results is easier in the autosomal dominant neoplasia syndromes, where one abnormal allele is sufficient for disease. In contrast, genetic testing in inherited metabolic syndromes (for example, congenital adrenal hyperplasia) is complex and less useful.…”

Section: Shern L Chew Consultant Physician and Professor Of Endocrinmentioning

confidence: 99%

Recent advances in the imaging of adrenal and neuroendocrine tumours

Narayanan

Reznek

2009

Clinical Medicine

View full text Add to dashboard Cite

The recent rapid development of imaging technology has revolutionised the detection of adrenal and neuroendocrine tumours by allowing more precise lesion characterisation and improving the staging of malignant disease. These developments are briefly reviewed below. Adrenal tumoursComputed tomography (CT) remains the cornerstone of adrenal imaging. Masses are initially assessed without contrast medium to measure their attenuation value (Hounsfield Unit, HU). About 70% of benign cortical adenomas will contain sufficient intracellular lipid to lower the attenuation value to 10 HU. If the attenuation value is greater than 10 HU, immediate and delayed scans are performed following administration of contrast for the calculation of contrast medium washout. In general, adenomas will demonstrate greater washout than a nonadenomatous lesion. This technique has a sensitivity of 98% and a specifity of 92% in differentiating an adenoma from other adrenal tumours. 1 With the advent of multidetector CT, it is now possible to obtain exquisite reformatted images of the adrenal glands in any plane. This has proven helpful determining whether a large mass is of renal or adrenal origin, and also in depicting possible invasion into adjacent organs.Chemical shift magnetic resonance imaging (MRI) is another powerful tool for the characterisation of adrenal lesions. It does not involve the use of ionising radiation or contrast medium and relies on the difference in resonance frequencies of protons in water and intracytoplasmic lipid. Adenomas typically lose signal on the out-of-phase images compared with the in-phase images and the loss of signal can be assessed visually. It therefore also depends on the presence of intracellular lipid and although more sensitive than unenhanced CT it is less sensitive than the CT washout techniques. The specificity of this technique is comparable to washout CT. 2 Newer functional imaging techniques of the adrenal gland such as positron emission tomography (PET)-CT and single photon emission computed tomography (SPECT) combine anatomic and functional information. 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG-PET) exploits the increased metabolism of glucose in malignant lesions. PET-CT with this tracer has a high specificity for the detection of malignant adrenal lesions but there have been reports of FDG uptake in benign lesions such as adrenal adenomas and myelolipomas. 3,4 FDG-PET is positive in the majority of phaeochromocytomas, whether benign or malignant. It is useful for the localisation of phaeochromocytomas that fail to concentrate MIBG. There have been several recent studies evaluating the use of PET using 11C-metomidate as a tracer. [5][6][7] This technique is highly sensitive and specific for differentiating between adrenocortical lesions (both carcinomas and adenomas) and non-adrenocortical masses. It remains to be seen if the cost and limited availability of metomidate (MTO)-PET will justify its widespread use in future. Neuroendocrine tumoursFunctioning pancreatic ne...

show abstract

Islet Cell Tumor of the Pancreas: Biphasic CT versus MR Imaging in Tumor Detection

Abstract: Biphasic (especially PVP) CT and MR imaging have similar effectiveness in the detection of islet cell tumors if fat-saturated T1-weighted and delayed enhanced T1-weighted MR imaging are included.

Cited by 253 publications

References 25 publications

Imaging of gastroenteropancreatic neuroendocrine tumors

Imaging of gastroenteropancreatic neuroendocrine tumors

Insulinoma: Literature’s Review (2)

Recent advances in the imaging of adrenal and neuroendocrine tumours

Contact Info

Product

Resources

About