Islet cell tumor arising from a heterotopic pancreas in the duodenal wall with ulceration

Invasive Ductal Carcinoma Arising from an Ectopic Pancreas in the Gastric Wall: A Long-Term Survival Case

“…Adenocarcinoma originating from an ectopic pancreas has been reported in several cases in the literature [4, 5, 6, 7, 8]. In this report, we describe a case of invasive ductal carcinoma arising from an ectopic pancreas in the stomach.…”

Adenocarcinoma Arising From Heterotopic Pancreas in the Duodenum

“…7 In recent studies, it has been reported to be in 0.6% to 13% of autopsies. 2,8 Although heterotopic pancreas can be found throughout the entire gastrointestinal tract, the most frequent sites are the organs near the pancreas such as the stomach (25%-60%), duodenum (30%), and jejunum (15%), because this entity has been thought to be due to a failure of the fusion in the 2 primitive pancreas. 7 Clinical symptoms caused by this entity are rather infrequent unless it is accompanied with size-up, bleeding, or concomitant pathologic changes.…”

“…1 Heterotopic pancreas is considered to result from the alteration of embryonic growth, whereby a part or all of the ventral anlagen of the primitive pancreas was left behind in the foregut. 2 The manifestations and complications of heterotopic pancreas include acute or chronic pancreatitis and cystic degeneration. 3,4 However, the malignant transformation of heterotopic pancreas is extremely rare.…”

Mucinous cyst exhibiting severe dysplasia in gastric heterotopic pancreas associated withe gastrointestinal stromal tumour

“…Heterotopic pancreas has been classified into three types by Heinrich: classⅠis typical pancreatic tissue with acini, ducts and islet cells, class Ⅱ shows a large number of acini and few ducts, and class Ⅲ shows numerous ducts with few acini or islet cells [5] . Neoplasms arising in heterotopic pancreatic tissue are rare [6] and include borderline mucinous cystic tumour [7] , adenocarcinoma [6] , mucinous cystadenocarcinoma [8] , acinar cell carcinoma [2] , islet cell tumour [9] , or solid and papillary neoplasm [10] . Cystic degeneration without malignant change appears to be more common and may mimic mucinous carcinoma from another primary site [11] .…”