Islet Autotransplantation Restores Normal Glucose Tolerance in a Patient With Chronic Pancreatitis

Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival

“…However, the results from 5-year follow-up demonstrated that approximately 80% of recipient patients had C-peptide present posttransplant, but only 10% maintained insulin independence (4,5). The fact that it requires only 1000 IEQ/kg in human autotransplants compared with 10,000 IEQ/kg in allotransplants reveals that alloreactive T cells contribute the most to islet allograft failure (19). The current paradigm of immunosuppression, including sirolimus and tacrolimus, has nearubiquitous targets of distribution and as a result leads to a number of side effects for the islet recipients and for the implanted islet ␤ cells (20 -25).…”

Clinical implementation of islet transplantation: A current assessment

“…Table shows the minimal islet mass expressed as IEQ/kg that has been associated with insulin independence of the recipient in three settings: clinical autologous and allogeneic islet transplantation and pre‐clinical (pig to non‐human primate) islet xenotransplantation . The gap in immunological compatibility remains the main cause for the need of higher number of islets; however, metabolic differences between animal species (such as pigs and Cynomolgous monkeys) further contribute to increased islet mass demand.…”

“…One of the consequences of improving compatibility between donor and recipient will translate to lower islet mass required to achieve glucose control after transplantation. Table 1 shows the minimal islet mass expressed as IEQ/kg that has been associated with insulin independence of the recipient in three settings: clinical autologous and allogeneic islet transplantation and pre-clinical (pig to non-human primate) islet xenotransplantation (13,15,26,32,37,52,53). The gap in immunological compatibility remains the main cause for the need of higher number of islets; however, Fig.…”

Evolution of -Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation

“…In a case study by Illouz et al, a patient suffering from chronic pancreatitis for more than two years and abnormal glucose tolerance test underwent pancreatectomy and islet autotransplantation and remains insulin independent 5 years after transplantation with less than 1,000 IEQ/kg body weight [ 294 ]. Interestingly, the same group has shown that no significant correlation exists between the number of islets transplanted and insulin independence.…”