Islet Autotransplantation After Extended Pancreatectomy for Focal Benign Disease of the Pancreas

Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis

“…This was not, therefore, considered of relevance to this particular review. TP/IAT has also been used for other indications including acute recurrent pancreatitis and benign neuroendocrine tumours 19 . Before establishing chronic pancreatitis as a cause of chronic intractable pain, confounding factors such as pseudocysts, malignancy, and biliary and gastric outlet obstruction should be excluded.…”

Autologous Islet Transplantation After Total Pancreatectomy for Renal Cell Carcinoma Metastases

“…Although autologous islet transplantation has successfully prevented surgical diabetes in patients with chronic pancreatitis, concern of inadvertent infusion of occult malignant cells in the islet preparation has restricted application of this approach in patients with underlying malignancies (10,17). A case report of total pancreatectomy with AIT in the setting of pancreatic head adenocarcinoma has been described previously (17).…”

“…Islet autotransplantation has been utilized for a selected series of benign pancreatic diseases, including pseudocysts, cystic neoplasms, insulinomas and neuroendocrine tumors (10,12,13). Balancing the potential benefit of preventing surgical diabetes against the oncologic risk of inadvertently embolizing tumor cells poses an interesting dilemma.…”

Pancreatic islet autotransplantation with total pancreatectomy for chronic pancreatitis

“…12 Since then, more than 500 islet autotransplantations with near-total or total pancreatectomy have been performed for chronic pancreatitis. 13 This treatment strategy, which is a combination of a surgical procedure and T. Kuroki et al 4 transplantation, has the potential to be the ideal therapy to resolve the patient's unbearable abdominal pain due to chronic pancreatitis without causing permanent pancreatic endocrine and exocrine insufficiency (Table 1).…”