İskemi-Reperfüzyon Hasarı ve Oksidatif Stress İlişkisine Biyokimyasal Bakış

Özcan, Oğuzhan; Erdal, Hüseyin; Yönden, Zafer

doi:10.17944/mkutfd.54113

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Intracellular protease activation and reoxygenation of the tissues in reperfusion result in production of reactive oxygen species (ROS) that cause tissue damage. 15 Due to its continued production, ATP is broken down into adenosine monophosphate and adenosine. Adenosine diffuses rapidly out of the cell and breaks down into inosine and hypoxanthine.…”

Section: Immunohistochemical Staining Of Caspase-3 Nuclear Factor-κbmentioning

confidence: 99%

Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits

Malçok

Aras

Şehitoğlu

et al. 2020

SMJ

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Section: Immunohistochemical Staining Of Caspase-3 Nuclear Factor-κbmentioning

confidence: 99%

Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits

Malçok

Aras

Şehitoğlu

et al. 2020

SMJ

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“…As a result of the abnormal increase of free radicals, this balance is disturbed in favor of free radicals and OS occurs. 7,8 Several studies in the literature have shown that OS plays a critical role in the pathogenesis of various diseases. [9][10][11][12][13][14][15][16][17][18] Studies have shown that FD patients have increased lipid and protein damage and decreased antioxidant defense system as a result of OS.…”

Section: Introductionmentioning

confidence: 99%

Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Erdal

Turğut

2023

Journal of Investigative Medicine

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This is the first study to evaluate thiol-disulfide homeostasis and oxidative stress (OS) levels in patients with Fabry Disease (FD). This prospective study consists of 30 FD patients and 30 healthy controls. The dynamic thiol-disulfide homeostasis of patients and control groups was evaluated by using the new, cost-effective and fully automated colorimetric method. A total of 60 patients and controls were included the present study. A statistically significant difference was found between the patient and control groups for native and total thiol levels (p<0.001). In addition, disulfide levels were significantly higher in FD patients compared with the control group (p<0.003). Native thiol levels showed significanlty negative correlation with Lyso-Gb3, total oxidant status (TOS) and oxidative stress index (OSI) levels. In addition, a positive correlation was found between disulfide/natural thiol and disulfide/total thiol ratios and TOS, OSI and BUN. We found total antioxidant status (TAS) levels were lower in the patient group compared to the control group, while TOS and OSI levels were higher and were statistically significant. This study highlights for the first time a novel, cost-effective and fully automated measurement of thiol -disulfide levels in patients with FD. Dynamic thiol- disulfide levels may contribute to the etiopathogenesis and follow-up of the disease in patients with FD.

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“…The basis of oxidative stress is the formation of free radicals secondary to the metabolism in blood cells, and the most important of these free radicals are reactive oxygen species (ROS) and reactive nitrogen species (RNS). 5,6 Although these free radicals cause many neurodegenerative diseases, such as dementia and parkinsonian diseases, they also cause various focal deficits. 7,8 Oxidative stress has also been found to be associated with many psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, they cause cell dysfunction or apoptosis. 5 There are three main types of ROS: superoxide radical (•O 2 -), hydroxyl radical ( • OH) and hydrogen peroxide (H 2 O 2 ), whereas RNS mainly emerge from nitric oxide (NO), nitrite dioxide (NO 2 ), peroxynitrite (ONOO -), and their derivatives. 10,11 Malondialdehyde (MDA) is used as a marker of oxidative stress, since it has a correlation with lipid peroxidation 12 Antioxidants are molecules that prevent oxidative stress, and they neutralize free radicals by donating one of their electrons.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Oxidative Stress Level and Antioxidant Enzyme Activities in Operated and Nonoperated Patients with Spontaneous Intracerebral Hematoma

Akyol

Demir

Görken

2022

J Neurol Surg A Cent Eur Neurosurg

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Background: Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal hemorrhage (ICH) are responsible for the highly detrimental effects on brain tissue. Oxidative stress also plays a significant role in brain damage after ICH; however, it is less important than other factors. In this study, we aimed to evaluate the oxidative stress parameters malondialdehyde (MDA) and the antioxidant reduced glutathione (GSH), superoxide dismutase (SOD) and catalase activities in operated and non-operated patients with spontaneous intracranial hematoma. Methods: One hunderd patients with spontaneous intracranial hemorrhage and 100 healthy control subjects were included in this study. Within the indication, 50 of the 100 patients underwent decompressive surgery. MDA, GSH, SOD, and catalase activities were measured in the serum obtained from the patients. Results: SOD and CAT levels were lower in the non-operated group than in the operated and control groups. GSH was not different between the operated and non-operated groups, but it was lower in the control group. However, MDA was higher in those who did not undergo surgery than in the other groups. Conclusions: In our study, MDA, an indicator of oxidative stress, was found to be lower in the blood, and CAT and SOD activities were found to be higher in ICH patients who underwent decompression than in those who did not. This is the first study to present the correlations of MDA, SOD, CAT, and GSH in operated and non-operated patients with spontaneous intracranial hematoma.

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İskemi-Reperfüzyon Hasarı ve Oksidatif Stress İlişkisine Biyokimyasal Bakış

Cited by 6 publications

References 15 publications

Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits

Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits

Thiol/disulfide homeostasis as a new oxidative stress marker in patients with Fabry disease

Investigation of Oxidative Stress Level and Antioxidant Enzyme Activities in Operated and Nonoperated Patients with Spontaneous Intracerebral Hematoma

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