ISG15 mediates the function of extracellular vesicles in promoting ovarian cancer progression and metastasis
Kalpana Deepa Priya Dorayappan,
Vincent Wagner,
Dongju Park
et al.
Abstract:The interferon stimulated gene 15 (ISG15), a ubiquitin like protein and its conjugates have been implicated in various human malignancies. However, its role in ovarian cancer progression and metastasis is largely unknown. In high grade serous ovarian cancer (HGSOC), ascites is the major contributor to peritoneal metastasis. In this study, we identified significantly elevated ISG15 protein expression in HGSOC patient ascites, ascites derived primary ovarian cancer cells (POCCs), POCC small extracellular vesicle… Show more
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