ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions

Becares, Martina; Albert, Manuel; Tarrega, Celine; Coloma, Rocio; Falqui, Michela; Luhmann, Emma; Radoshevich, Lilliana; Guerra, Susana

doi:10.1128/spectrum.04508-22

Cited by 1 publication

(1 citation statement)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IFN-induced ISG15 protein controls a plethora of cellular pathways, such as DNA damage response [ 11 ], regulation of DNA replication synthesis and stress [ 12 , 13 ], intracellular trafficking [ 14 ], modulation of cytoskeleton dynamics [ 15 ], autophagy [ 16 ], host antiviral response [ 17 ], and cancer occurrence and progression [ 18 ]. Additionally, ISG15 protein is involved in various mechanisms, such as modulation of immune response [ 19 ], vascular remodelling [ 20 ], mitochondrial functionality [ 21 ], energy metabolism [ 22 , 23 ], and macrophage activation [ 24 ].…”

Section: Isg15: General Features and Signallingmentioning

confidence: 99%

Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers

Álvarez,

Falqui,

Sin

et al. 2024

Vaccines

Self Cite

View full text Add to dashboard Cite

The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon (IFN) type I, ISG15 functions through diverse mechanisms: (i) covalent protein modification (ISGylation); (ii) non-covalent intracellular action; and (iii) exerting extracellular cytokine activity. These various roles highlight its versatility in influencing numerous cellular pathways, encompassing DNA damage response, autophagy, antiviral response, and cancer-related processes, among others. The well-established antiviral effects of ISGylation contrast with its intriguing dual role in cancer, exhibiting both suppressive and promoting effects depending on the tumour type. The multifaceted functions of ISG15 extend beyond intracellular processes to extracellular cytokine signalling, influencing immune response, chemotaxis, and anti-tumour effects. Moreover, ISG15 emerges as a promising adjuvant in vaccine development, enhancing immune responses against viral antigens and demonstrating efficacy in cancer models. As a therapeutic target in cancer treatment, ISG15 exhibits a double-edged nature, promoting or suppressing oncogenesis depending on the tumour context. This review aims to contribute to future studies exploring the role of ISG15 in immune modulation and cancer therapy, potentially paving the way for the development of novel therapeutic interventions, vaccine development, and precision medicine.

show abstract