Ischemic Stroke After Plasmapheresis

Salahuddin, Hisham; Sheikh, Ajaz; Hussaini, Sharmeen Fatima; Verghese, Cherian; Tietjen, Gretchen E.

doi:10.1016/j.amjms.2018.03.021

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…The high prevalence in the current study is related to the prevalence of this vice in rural Kenya45,48. Cigarette smoking causes endothelial dysfunction, inflammation, insulin resistance, alteration in lipid profile, hemodynamic stress, hypercoagulable state and oxidative stress, all of which contribute to vasomotor dysfunction and atherothrombosis49,50. Health campaigns to promote smoking cessation will help reduce the risk of stroke.…”

Section: Discussionmentioning

confidence: 75%

Pattern of stroke in a rural Kenyan hospital

et al. 2019

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Background The pattern of stroke in rural population differs from that in urban ones. Although there are many studies on this condition in sub-Saharan Africa, few studies about stroke pattern in a Kenyan rural area exist.. This study therefore aims at describing the characteristics of stroke in a rural Kenyan hospital. Patients and Methods The study was conducted on 227 consecutive patients admitted with a World Health Organization (WHO) diagnosis of stroke in Kangundo Hospital, a level IV facility in Machakos, Eastern Kenya, between April 2015 and September 2016. The sub-type and anatomical distribution of stroke as well as the age, gender of the patients were recorded prospectively. Diagnosis was made through physical neurological examination and confirmed by Computerized Tomography (CT) scan imaging. Only those with complete bio-data, past medical and social history, clinical and physical findings of the patients and imaging results were included. The data were entered into a pre-formatted questionnaire, analysed for means, standard deviations and frequencies, and are presented in tables and bar charts. Results Out of 3200 medical admissions, 227 (7.09%) had a confirmed diagnosis of stroke. Ischaemic stroke was more common (67.4%) than haemorrhagic stroke (32.6%). It affected mainly the anterior circulation, especially the middle cerebral artery (39%). The mean age of patients was 68.8 years, (Range 32–96). It was more common in females (62%) than in males (38%). Hypertension was the most common (74%) risk factor followed by alcohol abuse (63%), tobacco smoking (48%) and diabetes mellitus (42%). Conclusion Ischaemic stroke was the more common major cause of morbidity in the rural hospital studied in Kenya. It occurred most commonly among elderly females, with the most frequent comorbidities being hypertension. In addition, modifiable lifestyle factors like alcohol abuse and cigarette smoking contributed to the prevalence; hence we recommend the control of blood pressure and glucose as well as lifestyle modification to reduce the scourge in our studied population.

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Section: Discussionmentioning

confidence: 75%

Pattern of stroke in a rural Kenyan hospital

et al. 2019

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“…However, there is no evidence that the incidence of deep vein thrombosis in plasma donors is increased compared to a comparable population with the same age, gender, and contraceptive medication intake. Considering case reports of myocardial or cerebral infarcts by arterial thromboses, the incidence of severe cardiovascular diseases was even lower in donors of plasma than in the general population …”

Section: Clottingmentioning

confidence: 97%

Anticoagulation, bleeding, and clotting at donor plasmapheresis

Evers

Taborski

2018

J of Clinical Apheresis

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This article is based on a question of a colleague from North America how coagulation could be triggered between a donor's arm and a fistula needle during plasma donation (synonymous with donor plasmapheresis). The technique of venipuncture and citrate anticoagulation are described. Uncommon and rare problems such as prolonged bleeding, scarring, and thrombosis in plasma donors are discussed. If venous puncture and citrate: blood flow ratio at 1:16 are correctly performed, however, there will be no anticoagulation abnormalities due to plasma donation.

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“…[12][13][14] Intracranial arterial thrombosis leading to stroke is reported in two cases with underlying prothrombin gene mutation and raised Von Willebrand antigen and C-reactive Protein (CRP). 15 This indicates that presence of underlying coagulation pathway defects increases the risk of thrombosis following plasma donation. Large volume apheresis leading to cerebral infarction has also been reported but with underlying inherited thrombophilia.…”

Section: Case Reportmentioning

confidence: 99%

Lateral ST-elevation myocardial infarction after donation of COVID-19 convalescent plasma in a naïve donor

Shams

Tipoo

2021

BMJ Case Rep

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A 34-year-old man presented with central chest pain heralded by bilateral arm numbness, tingling and pain soon after donation of 1000 mL of COVID-19 convalescent plasma (CP). ECG showed ST-elevation in lateral leads and coronary angiogram showed large thrombus in diagonal branch of the left anterior descending artery. The patient underwent successful thrombus aspiration and percutaneous coronary intervention of diagonal branch. In this report, we describe a case of coronary thrombosis leading to ST-elevation myocardial infarction in a naïve plasma donor after donation of COVID-19 CP.

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Ischemic Stroke After Plasmapheresis

Cited by 6 publications

References 31 publications

Pattern of stroke in a rural Kenyan hospital

Pattern of stroke in a rural Kenyan hospital

Anticoagulation, bleeding, and clotting at donor plasmapheresis

Lateral ST-elevation myocardial infarction after donation of COVID-19 convalescent plasma in a naïve donor

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