Ischemic Preconditioning of the Rat Brain as a Method of Endothelial Protection from Ischemic/Repercussion Injury

Власов, Т. Д.; Коржевский, Д. Э.; Polyakova, E.

doi:10.1007/s11055-005-0095-0

Cited by 46 publications

(39 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The early and late phases of local IPC and the late phase of remote IPC were found to have endothelium-protecting actions evidenced as improvements in the recovery of cerebral blood flow in the postischemic period in preconditioned rats, with lower levels of endothelial desquamation and cerebral edema (Vlasov et al, 2005). Preconditioning with lipopolysaccharide (LPS), as a preconditioning stimulus, prevented ischemic cell death by reducing lesion size, and reduction of local cerebral blood flow in the peri-infarct area was inhibited in the LPS group, which was correlated with eNOS expression (Furuya et al, 2005).…”

Section: Ischemia and Inducible Nitric-oxide Synthasementioning

confidence: 96%

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

Toda

Ayajiki²,

Okamura³

2009

Pharmacol Rev

328

248

View full text Add to dashboard Cite

Section: Ischemia and Inducible Nitric-oxide Synthasementioning

confidence: 96%

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

Toda

Ayajiki²,

Okamura³

2009

Pharmacol Rev

328

248

View full text Add to dashboard Cite

“…IVC). Ischemic preconditioning in rats improved CBF during the reperfusion that followed the subsequent 30-min forebrain ischemia, and this functional effect was associated with reduced endothelial desquamation and brain edema (426). An upregulation of endothelial NOS (eNOS) may also contribute to improved recirculation in tolerant brain regions, since increased expression of eNOS mRNA was associated with ischemic tolerance induced by ischemic or LPS preconditioning (127,152,127).…”

Section: Does Preservation Of the Vascular Reactivity After The Testmentioning

confidence: 99%

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

Obrenovitch¹

2008

Physiological Reviews

230

176

View full text Add to dashboard Cite

Ischemic tolerance describes the adaptive biological response of cells and organs that is initiated by preconditioning (i.e., exposure to stressor of mild severity) and the associated period during which their resistance to ischemia is markedly increased. This topic is attracting much attention because preconditioning-induced ischemic tolerance is an effective experimental probe to understand how the brain protects itself. This review is focused on the molecular and related functional changes that are associated with, and may contribute to, brain ischemic tolerance. When the tolerant brain is subjected to ischemia, the resulting insult severity (i.e., residual blood flow, disruption of cellular transmembrane gradients) appears to be the same as in the naive brain, but the ensuing lesion is substantially reduced. This suggests that the adaptive changes in the tolerant brain may be primarily directed against postischemic and delayed processes that contribute to ischemic damage, but adaptive changes that are beneficial during the subsequent test insult cannot be ruled out. It has become clear that multiple effectors contribute to ischemic tolerance, including: 1) activation of fundamental cellular defense mechanisms such as antioxidant systems, heat shock proteins, and cell death/survival determinants; 2) responses at tissue level, especially reduced inflammatory responsiveness; and 3) a shift of the neuronal excitatory/inhibitory balance toward inhibition. Accordingly, an improved knowledge of preconditioning/ischemic tolerance should help us to identify neuroprotective strategies that are similar in nature to combination therapy, hence potentially capable of suppressing the multiple, parallel pathophysiological events that cause ischemic brain damage.

show abstract

“…Transient ischemia and reperfusion of limbs can elicit RIPC. Experimental animal studies have shown that RIPC reduces the volume of cerebral infarction caused by subsequent cerebral artery occlusion [8][9][10][11][12] . A clinical trial has also shown that RIPC could improve cerebral perfusion and could reduce recurrent strokes in patients with intracranial arterial stenosis [13] .…”

Section: Introductionmentioning

confidence: 99%

The Interventional Effect of Remote Ischemic Preconditioning on Cerebral Small Vessel Disease: A Pilot Randomized Clinical Trial

Mi¹,

Yu²,

et al. 2016

Eur Neurol

View full text Add to dashboard Cite

Background: Remote ischemic preconditioning (RIPC) of the limb has been shown to induce ischemic tolerance in basic and clinical studies that focused on sustained large artery occlusion rather than small vessel disease (SVD). This study aimed to evaluate the protective effects of brief repetitive limb RIPC on patients with cerebral SVD. Methods: Seventeen patients with cerebral SVD were enrolled. Patients underwent 5 ischemia-reperfusion cycles of preconditioning/sham preconditioning on both upper limbs twice a day for 1 year. Cerebral hemodynamic indexes, brain lesions, cognitive functions and assessment outcomes of dizziness handicap inventory (DHI) were analyzed. Results: In the RIPC group, the mean flow velocity (MFV) of the left middle cerebral artery (MCA) was accelerated (57.33 (52.33-61.34) vs. 51.33 (48.83-58.33), respectively; p = 0.038), and the post-treatment DHI score was reduced (18 (13-19) vs. 34 (21-45), respectively; p = 0.043). The post-treatment volume of the white matter lesions (WMLs) was also reduced (4.19 (2.96-7.25) vs. 6.06 (4.67-10.95), respectively; p = 0.050). There was no remarkable difference between the 2 groups either before or after treatment. Conclusion: The present study indicates that RIPC has potential beneficial effects on cerebral SVD by increasing the MFV of MCA, decreasing the DHI score as well as the volume of WMLs in patients with SVD.

show abstract

Ischemic Preconditioning of the Rat Brain as a Method of Endothelial Protection from Ischemic/Repercussion Injury

Cited by 46 publications

References 12 publications

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

The Interventional Effect of Remote Ischemic Preconditioning on Cerebral Small Vessel Disease: A Pilot Randomized Clinical Trial

Contact Info

Product

Resources

About