Ischemic preconditioning enhances regenerative capacity of hepatocytes after prolonged ischemia

Yamada, Fumihiko; Abe, Tsuyoshi; Saito, Takuro; Tsuciya, T; Ishii, Shunichi; Gotoh, M

doi:10.1016/s0041-1345(00)02283-1

Cited by 17 publications

(13 citation statements)

References 2 publications

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“…Similarly Yoshizumi et al [12]have demonstrated improved survival and increased tissue ATP with preconditioning in a rat liver resection model. Subsequently the IPC effect in the liver has been reproduced in several in vivo rodent models of partial and global liver ischemia [13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38]. These studies have demonstrated that liver IPC for warm ischemia resulted in decreased hepatocellular injury [17, 18], increased tissue ATP [12, 22], decreased tumor necrosis factor-α (TNF-α) [19, 31]and IL-6 [31]release, decreased leukocyte/endothelial cell interactions [25], decreased endothelial cell injury [39], increased peripheral liver blood flow [24], increased microcirculation [40, 41], decreased hepatocellular apoptosis [27], preserved energy metabolism [21], increased hepatic intracellular oxygenation [42]and remote organ protection [23].…”

Section: Evidence That Ipc Occurs In the Livermentioning

confidence: 99%

Protection of the Liver by Ischemic Preconditioning: A Review of Mechanisms and Clinical Applications

Koti¹,

Seifalian²,

Davidson³

2003

Dig Surg

115

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Ischemic preconditioning refers to the endogenous mechanism of protection against a sustained ischemic insult following an initial, brief ischemic stimulus. Ischemia-reperfusion injury of the liver is a major cause of morbidity and mortality in liver surgery and transplantation and ischemic preconditioning is a promising strategy for improving the outcome of liver surgery. The preconditioning phenomenon was first described in a canine model of myocardial ischemia-reperfusion injury in 1986 and since then has been shown to exist in other organs including skeletal muscle, brain, kidneys, retina and liver. In the liver, the preconditioning effect has been demonstrated in rodents and a recent study has demonstrated human clinical benefits of preconditioning during hemihepatectomies. Ischemic preconditioning has been described as an adaptive response and although the precise mechanism of hepatoprotection from preconditioning is unknown it is likely to be a receptor-mediated process. Several hypotheses have been proposed and this review assesses possible mechanisms of ischemic preconditioning and its role in hepatic surgery and liver transplantation. The future lies in defining the mechanisms of the ischemic preconditioning effect to allow drug targeting to induce the preconditioning response.

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Section: Evidence That Ipc Occurs In the Livermentioning

confidence: 99%

Protection of the Liver by Ischemic Preconditioning: A Review of Mechanisms and Clinical Applications

Koti¹,

Seifalian²,

Davidson³

2003

Dig Surg

115

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“…Thus, it appears that a low dose of TNF-α is required for the protective effect of IPC, as previously suggested (221). In addition to these protective mechanisms, IPC induces a regenerative response in the liver that might be mediated by NF-κB activation (204,211).…”

Section: Ischemic Preconditioning (Ipc)mentioning

confidence: 56%

“…In the mid-1990s, this concept started to spread to liver surgery and has been a topic of intense research during recent years (202). Multiple studies in rodents have demonstrated that ischemic preconditioning (IPC) is effective in reducing IRI in healthy animals as well as in obese animals and those with fatty liver (183,(203)(204)(205)(206)(207)(208)(209)(210)(211)(212)(213).…”

Section: Ischemic Preconditioning (Ipc)mentioning

confidence: 99%

Methods to Reduce Liver Ischemia/Reperfusion Injury

Björnsson¹

2014

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“…Most of these studies applied one cycle of brief ischemia (usually 5-10 min) followed by 5-10 min of reperfusion [9,14] . However, based on previous studies by our group on different organs [15,16] , pilot experiments with a similar setting and consultation with liver surgeons, we decided to introduce a preclamping procedure which would suit the need for shortterm effects consisting of three cycles of 10 min of ischemia followed by 10 min of reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Effects of N-Acetylcysteine and Ischemic Preconditioning in a Canine Model of Hepatic Ischemia-Reperfusion Injury

et al. 2008

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Aims: We evaluated the possibility that repeated ischemic preconditioning or N-acetylcysteine (NAC) could prevent ischemia-reperfusion injury as determined by indocyanine green plasma disappearance rate (ICG-PDR) or has favorable hemodynamic effects during reperfusion in an in vivo canine liver model. Methods: Under general anesthesia, 3 groups of mongrel dogs (n = 5 per group) were subjected to (1) 60-min hepatic ischemia, (2) same ischemia preceded by intravenous administration of 150 mg kg^–1 NAC, and (3) three episodes of IPC (10-min ischemia followed by 10-min reperfusion) prior to same ischemia. Hepatic reperfusion was maintained for a further 180 min, with hemodynamic and hepatic function parameters monitored throughout. Results: Plasma disappearance rate of indocyanine green and serum levels of aspartate transferase and alanine transferase showed no significant differences between groups. Although liver injury was obvious, reflected by hemodynamic, blood gas, and liver function tests, NAC and IPC failed to prevent decay in hepatic function in this canine model. Conclusion: The results do not support the hypothesis that short-term use of NAC and IPC is beneficial in hepatic surgery.

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Ischemic preconditioning enhances regenerative capacity of hepatocytes after prolonged ischemia

Cited by 17 publications

References 2 publications

Protection of the Liver by Ischemic Preconditioning: A Review of Mechanisms and Clinical Applications

Protection of the Liver by Ischemic Preconditioning: A Review of Mechanisms and Clinical Applications

Methods to Reduce Liver Ischemia/Reperfusion Injury

Short-Term Effects of N-Acetylcysteine and Ischemic Preconditioning in a Canine Model of Hepatic Ischemia-Reperfusion Injury

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