Ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats

Leng, Y.F.; Zhang, Y.; Zhang, Y.; Xue, X.; Wang, T.; Kang, Y.Q.

doi:10.1590/s0100-879x2011000500005

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…After histological analysis according Chiu et al 20 it was demonstrated that without PTX 1,13,14,16 and PGE1 [17][18][19][20] The PGE1 [17][18][19], is known by its intense vasodilator effect, for being a substance with intense biological activity that has been used for such a longtime to treat. the chronic arterial occlusive disease, since beside to vasodilation capacity it also inhibit platelets aggregation.…”

Section: Discussionmentioning

confidence: 99%

“…A PTX 1,13,14,16 has an antioxidant action directly inhibiting the anion superoxide that also indirectly block xanthine-oxidase enzyme activity. Therefore, it seems to decrease intensity of inflammatory response reducing neutrophils migration to the local area, decreasing liberation of cytokines, of tumoral necrosis factor, platelet activator factor and endothelin among other factors.…”

Section: Discussionmentioning

confidence: 99%

“…At those areas the integrity of cell membrane could suffer with hypoxia and the cell itself could miss the ideal amount of energy production as well as accumulate, direct or indirectly, metabolites and inflammatory mediators causing cellular dysfunction [9][10][11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

“…PTX has antioxidant action inhibiting directly the anion superoxide, which indirectly blocks the action of the enzyme xanthine-oxidase. Beside to that, it seems to diminish the intensity of inflammatory response, reduce migration of neutrophils to the area, difficult the liberation of citokynes, the tumoral necrosis factor, platellet activating factors and endothelin, a potent vasoconstrictor substance, among other factors 1,13,14,16 . The PGE1 is known by its intense vasodilator effect and as a substance with intense biological activity that has been used for such a longtime in the treatment of chronic occlusive arterial disease.…”

Section: Introductionmentioning

confidence: 99%

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Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Brasileiro

Inoye²,

Aydos³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS:Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately . In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS:Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION:Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Brasileiro

Inoye²,

Aydos³

et al. 2013

Acta Cir. Bras.

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“…It is important to point out the cyclic character of this process, since the initial damage to the intestinal barrier is probably caused by the excessive production of free radicals, primarily and inflammatory cytokines, complementary. This occurs because the free radicals produced during the reperfusion period are the main agents responsible for the injuries in organs which are distant from those that suffered ischemia 5,15,16 . Considering that the ORS take part in the induction mechanism and the inflammation action, it is postulated that by reducing their formation, there will be reduction in the inflammation, minimizing the reperfusion injury.…”

mentioning

confidence: 99%

Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats

Gomes

Romanek²,

Przybycien³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha). METHODS:Sixty rats were distributed into two groups: control and allopurinol and each group was divided into three subgroups, ischemia for two hours, ischemia for three hours and ischemia simulation. Allopurinol group rats received 100mg/kg dose of allopurinol, whereas control group rats received an equivalent dose of saline. Clamping of the infrarenal aorta was performed for two or three hours depending on the subgroup. Ischemia simulation subgroups did not suffer ischemia, just aortic dissection, and maintenance for three hours. After 72 hours of reperfusion, blood was collected by cardiac puncture for TNF-alpha measurement. RESULTS:Allopurinol reduced TNF-alpha significantly (p <0.001) when compared to the matching control subgroups (control X allopurinol in ischemia for two hours and for three hours). CONCLUSION:Allopurinol reduced the concentrations of serum TNF-alpha when used at different times of ischemia followed by reperfusion, which might indicate reduction of the inflammation provoked by the reperfusion injury.

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Protective effects of HO‐1 pathway on lung injury subsequent to limb ischemia reperfusion

Liu

et al. 2019

The Kaohsiung J of Med Scie

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Limb ischemia reperfusion (LIR) can activate endogenous cytoprotective mechanisms by generating specific proteins against reperfusion injury in remote organs. The present study investigated the roles of heme oxygenase‐1 (HO‐1) pathway and the molecular mechanisms underlying the regulation of this pathway on lung injury following LIR. LIR was induced by ischemia for 4 hours followed by reperfusion for 6 hours (LIR 6 hours) or 16 hours (LIR 16 hours) in male Sprague‐Dawley rats. HO‐1 inducer cobalt protoporphyrin (Copp) or HO‐1 inhibitor zinc protoporphyrin (Znpp) was intravenously injected 24 hours before ischemia. The animals were randomly divided into nine groups, including normal control, LIR 6 hours, LIR 16 hours, Copp, Copp + LIR 6 hours, Copp + LIR 16 hours, and Znpp, Znpp+ LIR 6 hours, and Znpp + LIR 16 hours groups (each group included four samples). Lung injury was examined through histopathology. Quantitative real‐time PCR, immunohistochemistry and Western blot were applied to detect the mRNA and protein levels of HO‐1, Nrf2, and Bach1. Our study showed that LIR induced Nrf2 upregulation but Bach1 downregulation to promote HO‐1 expression in lung tissues. Activation of HO‐1 pathway by Copp potentially enhanced Nrf2 expression but inhibition of the pathway by Znpp promoted Bach1 expression. Inducer of HO‐1 pathway, Copp injection improved the lung injury. Nevertheless, Znpp injection aggravated the lung injury following LIR. Our findings suggested that activated HO‐1 pathway might exert protective effects on the lung injury following LIR.

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Ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats

Cited by 17 publications

References 22 publications

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1

Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats

Protective effects of HO‐1 pathway on lung injury subsequent to limb ischemia reperfusion

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