Ischemic Penumbra: A Personal View

Davis, Stephen M.; Donnan, Geoffrey A

doi:10.1159/000519730

Cited by 5 publications

(3 citation statements)

References 100 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Violations of the functional state of erythrocytes lead to microcirculation disorders. This is an important factor in the pathogenesis of ischemic cerebrovascular accidents [1,7,8,9,10]. In recent years, a large number of experimental and clinical studies have been carried out, which have shown that a good in-depth diagnosis and adequate treatment at first is an undeniable advantage for the management of patients with cerebral stroke.…”

Section: Discussion Discussionmentioning

confidence: 99%

Comparative assessment of macro-,micro- and molecular rheological factors in patients with ischemic stroke. (Preliminary results)

2023

bmms

View full text Add to dashboard Cite

Currently, the main cause of death in the developed countries of the world arediseasesofthecirculatorysystem,includingvasculardiseasesofthebrain.are diseases of the circulatory system, including vascular diseases of the brain. Thedevelopmentandimplementationofnewprogramsandmethodsfordi-The development and implementation of new programs and methods for di-agnosing,treatingandpreventingcerebrovasculardiseasesisthemostimport-agnosing, treating and preventing cerebrovascular diseases is the most import-antmedical,socialandeconomictask.Prioritizationoffundamentalstudiesinant medical, social and economic task. Prioritization of fundamental studies in thefieldsofneurologyandangiologyhasbeenthestudyofpathophysiologicalthe fi elds of neurology and angiology has been the study of pathophysiological mechanismsofischemicstrokedevelopment,asstudyofrheologicalproperties.mechanisms of ischemic stroke development, as study of rheological properties. Ourgoalwastostudyagroupofpatientswithischemicbrainstroke.OurgroupOur goal was to study a group of patients with ischemic brain stroke. Our group wasfrom10peoplewithanaverageage72±5,4years,thecontrolgroupcon-was from 10 people with an average age 72±5,4 years, the control group con-sistedofvolunteersaged69±2,3years(n=12).Allsubjectsunderwentthefol-sisted of volunteers aged 69±2,3 years (n=12). All subjects underwent the fol-lowingstudies1)Tomonitoracrorheologicalfactors,weexaminedhematocritlowing studies 1) To monitor acrorheological factors, we examined hematocrit andplasmaviscosity.ForthisweusedHumanCounter,Germany.2)Tomonitorand plasma viscosity. For this we used HumanCounter, Germany. 2) To monitor macrorheologicalfactors,westudiedtheaggregabilityoferythrocytesandthemacrorheological factors, we studied the aggregability of erythrocytes and the deformabilityoferythrocytemembranes.Forthisweusedthetextureanalysisdeformability of erythrocyte membranes. For this we used the texture analysis methodandthefiltrationmethod.Itturnedoutthatinthegroupofpatientsmethod and the fi ltration method. It turned out that in the group of patients withischemicstroke,allparameterswerechanged,butthepercentageofsignifi-with ischemic stroke, all parameters were changed, but the percentage of significant destruction was most observed in the direction of microrheological factors, moreprecisely,theaggregationoferythrocyteschangedbymorethan2timesmore precisely, the aggregation of erythrocytes changed by more than 2 times comparedtothecontrolgroup.Ourpreliminaryexperimentshaveshownthatcompared to the control group. Our preliminary experiments have shown that erythrocyteaggregationisanecessaryparameterforassessingbloodrheology.erythrocyte aggregation is a necessary parameter for assessing blood rheology

show abstract

Section: Discussion Discussionmentioning

confidence: 99%

Comparative assessment of macro-,micro- and molecular rheological factors in patients with ischemic stroke. (Preliminary results)

2023

bmms

View full text Add to dashboard Cite

show abstract

“…After ischemic stroke, the neurons in the stroke center rapidly undergo apoptosis and necrosis because of ischemia and hypoxia, whereas the surrounding cells still have transient survival ability because of the existence of collateral circulation, thus forming an ischemic penumbra. Within a certain period of time, cells in this area can either undergo apoptosis or return to the normal brain tissue (Bonnin et al, 2021;Davis and Donnan, 2021;Yang and Liu, 2021). If the ischemic penumbra is rescued in time, it can effectively prevent stroke progression; further, the successful rescue of ischemic penumbra is also conducive to the recovery of the nervous system and physical function in the future.…”

Section: Rapid Restoration Of Cerebral Blood Supply and Improvement O...mentioning

confidence: 99%

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

Zhu¹,

Meng²,

Jiang³

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Ischemic stroke is a common cause of death and disability worldwide, which leads to serious neurological and physical dysfunction and results in heavy economic and social burdens. For now, timely and effective dissolution of thrombus, and ultimately improvement in the recovery of neurological functions, is the treatment strategy focus. Recently, many studies have reported that transcranial ultrasound stimulation (TUS), as a non-invasive method, can dissolve thrombus, improve cerebral blood circulation, and exert a neuroprotective effect post-stroke. TUS can promote functional recovery and improve rehabilitation efficacy among patients with ischemic stroke. This mini-review summarizes the potential mechanism and limitation of TUS in stroke aims to provide a new strategy for the future treatment of patients with ischemic stroke.

show abstract

“…This ischemic core is surrounded by hypo-perfused tissue with some preserved metabolic activities, which is also known as the penumbra. Penumbra denotes the potentially salvageable brain tissue amenable to reperfusion therapy ( 9 ). Hemorrhagic stroke is responsible for 10–15 percent of all strokes and has a high mortality rate.…”

Section: Introductionmentioning

confidence: 99%

Clinical experience: Outcomes of mesenchymal stem cell transplantation in five stroke patients

et al. 2023

View full text Add to dashboard Cite

Stem cell therapy, which has promising results in acute disorders such as stroke, supports treatment by providing rehabilitation in the chronic stage patients. In acute stroke, thrombolytic medical treatment protocols are clearly defined in neurologic emergencies, but in neurologic patients who miss the “thrombolytic treatment intervention window,” or in cases of hypoxic-ischemic encephalopathy, our hands are tied, and we are still unfortunately faced with hopeless clinical implementations. We consider mesenchymal stem cell therapy a viable option in these cases. In recent years, novel research has focused on neuro-stimulants and supportive and combined therapies for stroke. Currently, available treatment options are limited, and only certain patients are eligible for acute treatment. In the scope of our experience, five stroke patients were evaluated in this study, who was treated with a single dose of 1–2 × 106 cells/kg allogenic umbilical cord-mesenchymal stem cells (UC-MSCs) with the official confirmation of the Turkish Ministry of Health Stem Cell Commission. The patients were followed up for 12 months, and clinical outcomes are recorded. NIH Stroke Scale/Scores (NIHSS) decreased significantly (p = 0.0310), and the Rivermead Assessment Scale (RMA) increased significantly (p = 0.0234) for all patients at the end of the follow-up. All the patients were followed up for 1 year within a rehabilitation program. Major clinical outcome improvements were observed in the overall clinical conditions of the UC-MSC treatment patients. We observed improvement in the patients’ upper extremity and muscle strength, spasticity, and fine motor functions. Considering recent studies in the literature together with our results, allogenic stem cell therapies are introduced as promising novel therapies in terms of their encouraging effects on physiological motor outcomes.

show abstract

Ischemic Penumbra: A Personal View

Cited by 5 publications

References 100 publications

Comparative assessment of macro-,micro- and molecular rheological factors in patients with ischemic stroke. (Preliminary results)

Comparative assessment of macro-,micro- and molecular rheological factors in patients with ischemic stroke. (Preliminary results)

The Updated Role of Transcranial Ultrasound Neuromodulation in Ischemic Stroke: From Clinical and Basic Research

Clinical experience: Outcomes of mesenchymal stem cell transplantation in five stroke patients

Contact Info

Product

Resources

About