Ischemic ocular manifestations of giant cell arteritis: A Canadian case series

Issa, Mariam; Donaldson, Laura; Jeeva-Patel, Trishal; Margolin, Edward

doi:10.1016/j.jns.2022.120222

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…In a retrospective study of 36 patients with systemic GCA, only 8 (22%) had a history of TMVL [ 24 ]. In a similar study of 122 patients with GCA at the Mayo clinic, TMVL was observed in 20 cases (16%), followed by an acute loss of vision in 16 of these cases and diplopia in 12 [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Douglas,

Rachapudi,

Davila-Siliezar

et al. 2024

Ophthalmol Ther

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Transient monocular visual loss (TMVL), also known as transient monocular blindness or amaurosis fugax (“fleeting blindness”), is a temporary loss of vision often due to ischemia to the retina. While acute TMVL should be considered an emergency that further requires exhaustive investigation, there are some cases in which TMVL arises secondary to benign causes. Age has a major impact in the diagnosis of ischemia and although the differential diagnosis of TMVL can be broad, timely and appropriate history, examination, diagnostic testing, and treatment can be vision- or life-saving. We review the causes of TMVL and the impact of age on the differential diagnoses and management.

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Section: Resultsmentioning

confidence: 99%

Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Douglas,

Rachapudi,

Davila-Siliezar

et al. 2024

Ophthalmol Ther

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“… 34 35 Moreover, AAION patients tended to be older males, which is also consistent with previous studies. 36 37 Therkildsen et al 38 reported that among patients with GCA, age ≥70 years and male sex increased the risk of ocular manifestations. These findings indicate that, despite the small number of patients in Korea, the present findings may be reliable.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study

Kang,

Hong,

Kim

et al. 2024

J Clin Neurol

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Background and Purpose Giant-cell arteritis (GCA) is the most common type of vasculitis in the elderly and is associated with high risks of visual loss and recurrence. Owing to its rarity in Asian populations, the current clinical interventions for these patients are not well known. Here we aimed to characterize the current management status of patients with GCA using Korean multicenter data. Methods This retrospective study analyzed medical records of patients with GCA at six Korean university hospitals from February 2009 to November 2022. GCA had originally been diagnosed based on the 1990 American College of Rheumatology (ACR) criteria, and cases were selected for inclusion in this study based on the 2022 ACR/European Alliance of Associations for Rheumatology criteria. We evaluated treatments, follow-up periods, and outcomes (relapse, remission, and adverse drug reactions) in patients with GCA with or without arteritic anterior ischemic optic neuropathy (AAION). Results This study analyzed 18 patients with a median age of 75.5 years that included 12 females (66.7%). Seven patients (38.8%) had AAION. All patients initially received prednisolone treatment, while four (22.2%) underwent adjuvant treatment with methotrexate and azathioprine during prednisolone tapering. During the median follow-up of 3.5 months (interquartile range: 2.0–23.2 months), 4 patients (22.2%) had prednisolone-related adverse reactions, 2 (11.1%) relapsed, and 13 (72.3%) dropped out. Nine patients (50.0%) experienced remission, with this being sustained in four (36.4%). Conclusions This study observed high dropout rates and short follow-ups. Adverse effects of prednisolone were common, and relapses occurred in approximately one-tenth of Korean patients with GCA. Thus, optimizing GCA treatment necessitates regular monitoring and long-term follow-up.

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Frequency of visual involvement in a 10-year interdisciplinary cohort of patients with giant cell arteritis

et al. 2023

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Ischemic ocular manifestations of giant cell arteritis: A Canadian case series

Cited by 3 publications

References 16 publications

Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Transient Monocular Visual Loss (Amaurosis Fugax): How Does Age Impact Diagnosis?

Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study

Frequency of visual involvement in a 10-year interdisciplinary cohort of patients with giant cell arteritis

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