Ischemic myocardial injuries after cardiac malformation repair in infants may be associated with oxidative stress mechanisms

Oliveira, Marcela S.; Floriano, Elaine M.; Mazin, Suleimy Cristina; Martinez, Edson Zangiacomi; Vicente, W.; Peres, Luíz César; Rossi, Marcos A.; Ramos, Simone G.

doi:10.1016/j.carpath.2010.01.012

Cited by 18 publications

(12 citation statements)

References 25 publications

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“…During TD experimentally induced, greater proportion of apoptotic myocytes by TdT-mediated dUTP nick end labeling (TUNEL) and caspase-3 reactivity techniques have been recently described [13]. These results indicate that during TD, reactive oxygen species (ROS) production may be enhanced as a consequence of the installed acidosis [14]. The perturbation in the cardiac myocytes redox balance was responsible for the increase in apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiac beriberi: morphological findings in two fatal cases

et al. 2011

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Cardiovascular beriberi is categorized into two main groups, according to its cause: alcoholic and non-alcoholic (dietary). Cardiovascular beriberi can also be divided into a fulminant form (Shoshin beriberi) and a chronic form. Shoshin beriberi is characterized by hypotension, tachycardia, and lactic acidosis and is mainly encountered in non-alcoholic patients in Asian countries, although it has also been seen in alcoholics in Western countries. Due to the complex clinical presentation and to the lack of diagnostic tests, thiamine deficiency is still being missed, especially among non-alcoholics patients. We present two fatal cases of non - alcohol associated cardiac beriberi. An acute myocardial infarction was observed in one case; extensive colliquative myocytolisis (grade 2) was described in the second case respectively. Morphologically, myocardial necrosis and colliquative myocytolysis are the histologic hallmarks of this acute, rare clinical entity. An increase in apoptotic myocytes was demonstrated probably sustaining the cardiogenic shock.

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Section: Discussionmentioning

confidence: 99%

Cardiac beriberi: morphological findings in two fatal cases

et al. 2011

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“…In inappropriate myocardial protection, contraction band necrosis and dystrophic calcifications were observed on the myocardium, leading to an increase in early and late postoperative complications, decreased cardiac performance and impaired quality of life (8). Hypoperfusion of organs and tissues due to low cardiac output syndrome leads to metabolic acidosis, development of severe organ dysfunctions and accumulation of endogenous toxins, which ultimately contribute to the development of multiple organ dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Coronary Sinus Lactate as Marker of Myocardial Ischemia in Cardiac Surgery: Correlation with Morbidity and Mortality after Cardiac Surgery / Lactatul din sinusul coronarian - marker al ischemiei miocardice în chirurgia cardiacă: corelaţii cu morbiditatea şi mortalitatea postoperatorie

Raicea¹,

Kovács²,

Moraru³

et al. 2015

Romanian Review of Laboratory Medicine

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“…The activated neutrophil with subsequent fabrication of ROS seems to play a role in more prolonged periods of ischaemia that are associated with tissue necrosis [ 8 , 34 ]. Oliveira et al [ 35 ] in an immunohistological study of infants that underwent repair of cardiac malformations found lipid peroxidation to be the mechanism responsible for myocardial injury. The authors tested immunoreactivity to 4-hydroxynonenal, a lipid peroxidation product, and nitrotyrosine, a tyrosine nitration product, mediated by the peroxynitrite radical.…”

Section: Paediatric Extracorporeal Circuits and Oxidative Stressmentioning

confidence: 99%

Oxidative Stress after Surgery on the Immature Heart

Fudulu

Angelini

2016

Oxidative Medicine and Cellular Longevity

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Paediatric heart surgery is associated with increased inflammation and the production of reactive oxygen species. Use of the extracorporeal cardiopulmonary bypass during correction of congenital heart defects generates reactive oxygen species by various mechanisms: haemolysis, neutrophil activation, ischaemia reperfusion injury, reoxygenation injury, or depletion of the endogenous antioxidants. The immature myocardium is more vulnerable to reactive oxygen species because of developmental differences compared to the adult heart but also because of associated congenital heart diseases that can deplete its antioxidant reserve. Oxidative stress can be manipulated by various interventions: exogenous antioxidants, use of steroids, cardioplegia, blood prime strategies, or miniaturisation of the cardiopulmonary bypass circuit. However, it is unclear if modulation of the redox pathways can alter clinical outcomes. Further studies powered to look at clinical outcomes are needed to define the role of oxidative stress in paediatric patients.

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Ischemic myocardial injuries after cardiac malformation repair in infants may be associated with oxidative stress mechanisms

Cited by 18 publications

References 25 publications

Cardiac beriberi: morphological findings in two fatal cases

Cardiac beriberi: morphological findings in two fatal cases

Coronary Sinus Lactate as Marker of Myocardial Ischemia in Cardiac Surgery: Correlation with Morbidity and Mortality after Cardiac Surgery / Lactatul din sinusul coronarian - marker al ischemiei miocardice în chirurgia cardiacă: corelaţii cu morbiditatea şi mortalitatea postoperatorie

Oxidative Stress after Surgery on the Immature Heart

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