Ischemic heart disease induce upregulation of endothelin receptor mRNA in human coronary arteries

Wackenfors, Angelica; Emilson, Malin; Ingemansson, Richard; Hortobágyi, Tibor; Delia, S.; Tajti, János; Vécsei, László; Edvinsson, Lars; Malmsjö, Malin

doi:10.1016/j.ejphar.2003.11.001

Cited by 65 publications

(63 citation statements)

References 32 publications

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“…Initially, organ culture demonstrated an upregulation of ET B2 receptors in rat mesenteric VSMC after 1-5 days of culture (Adner et al, 1998b). This receptor upregulation also takes place in human coronary arteries after organ culture (Wackenfors et al, 2003) and in human ischemic heart disease (Wackenfors et al, 2004). Changes in the endothelin receptor phenotype seen during organ culture of rat cerebral and peripheral arteries are similar to the endothelin receptor phenotype changes observed in peripheral artery disease (Lind et al, 1999), in subarachnoidal hemorrhage (Hansen-Schwartz et al, 2003) and after cerebral ischemic stroke (Stenman et al, 2002).…”

Section: Endothelin Receptorsmentioning

confidence: 75%

“…In human atherosclerotic lesions, there is also an increase in 18 ET-1 and ET B receptors and this increase is seen in the medial VSMC, just beneath the foam cells (Iwasa et al, 1999). Increased ET B receptor-mediated responses have been demonstrated in human blood vessels of patients with ischaemic heart disease (Wackenfors et al, 2004) and after experimental ischemic stroke in rats (Stenman et al, 2002). These data suggest that the upregulation of endothelin receptors is an important molecular mechanism that mediates the development of CVD.…”

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 91%

“…Chronic intermittent hypoxia increased the expression of ET B receptors in the carotid body (Rey et al, 2007). Increased ET B receptor expression has also been seen in blood vessels of patients with ischemic heart disease (Wackenfors et al, 2004) and after experimental ischemic stroke in rats (Stenman et al, 2002). This suggests a role for hypoxia and re-oxygenation in the process of induced ET B receptor expression in vivo.…”

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 93%

“…Upregulation of endothelin receptors has been demonstrated in patients with CVD (Wackenfors et al, 2004;Nilsson et al, 2008a) and in experimental animal models of 17 cerebral ischemia (Stenman et al, 2002). ET B2 receptor expression is increased in the VSMC of resistance arteries from patients with ischemic heart disease, while no alteration is seen in the expression of ET A receptors.…”

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 99%

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Cardiovascular risk factors regulate the expression of vascular endothelin receptors

Xu¹,

Sun²,

Edvinsson³

2010

Pharmacology & Therapeutics

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Cardiovascular disease remains as the leading cause of death in the developed world.However, there is limited knowledge about how cardiovascular risk factors actually cause vascular disease. Traditional cardiovascular risk factors include increased circulating levels of low-density lipoproteins, cigarette smoking and hypertension (both strongly related to arterial wall injury), inflammation and atherosclerosis.

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Section: Endothelin Receptorsmentioning

confidence: 75%

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 91%

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 93%

Section: Upregulation Of Vascular Endothelin Receptorsmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular risk factors regulate the expression of vascular endothelin receptors

Xu¹,

Sun²,

Edvinsson³

2010

Pharmacology & Therapeutics

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“…Contractile endothelin ET B receptors are upregulated in vascular smooth muscle cells during organ culture (Adner et al, 1998a andAdner et al, 1998b) and in pathological conditions, e.g. in cerebral ischemia (Stenman et al, 2002) and in coronary ischemia (Wackenfors et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelin ETB receptor-mediated contraction requires phosphorylation of ERK1/2 proteins

Luo

Jamali

Cao

et al. 2006

European Journal of Pharmacology

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In cardiovascular diseases, endothelin type B (ET B ) receptors in arterial smooth muscle cells are upregulated. The present study revealed that organ culture of rat mesenteric artery segments enhanced endothelin ET B receptor-mediated contraction paralleled with increase in the receptor mRNA and protein expressions. The endothelin ET B receptor-mediated contraction was associated with increase in phosphorylation of extracellular regulation kinase 1 and 2 (ERK1/2) proteins and elevated levels of intracellular calcium. The elevation curve of intracellular calcium consisted of two phases: one rapid and one sustained. Inhibition of ERK1/2 phosphorylation by SB386023 or blockage of calcium channels by nifedipine significantly reduced the endothelin ET B receptor-mediated contraction (P<0.05) and decreased the sustained phase of intracellular calcium level, but not the rapid phase. Thus, phosphorylation of ERK1/2 proteins and elevation of intracellular calcium level are required for endothelin ET B receptor-mediated contraction in rat mesenteric artery.

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Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction

Duncker

Beer

Merkus

2008

Med Biol Eng Comput

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The mechanism underlying the progressive deterioration of left ventricular (LV) dysfunction after myocardial infarction (MI) towards overt heart failure remains incompletely understood, but may involve impairments in coronary blood flow regulation within remodelled myocardium leading to intermittent myocardial ischemia. Blood flow to the remodelled myocardium is hampered as the coronary vasculature does not grow commensurate with the increase in LV mass and because extravascular compression of the coronary vasculature is increased. In addition to these factors, an increase in coronary vasomotor tone, secondary to neurohumoral activation and endothelial dysfunction, could also contribute to the impaired myocardial oxygen supply. Consequently, we explored, in a series of studies, the alterations in regulation of coronary resistance vessel tone in remodelled myocardium of swine with a 2 to 3-week-old MI. These studies indicate that myocardial oxygen balance is perturbed in remodelled myocardium, thereby forcing the myocardium to increase its oxygen extraction. These perturbations do not appear to be the result of blunted β-adrenergic or endothelial NO-mediated coronary vasodilator influences, and are opposed by an increased vasodilator influence through opening of KATP channels. Unexpectedly, we observed that despite increased circulating levels of noradrenaline, angiotensin II and endothelin-1, α-adrenergic tone remained negligible, while the coronary vasoconstrictor influences of endogenous endothelin and angiotensin II were virtually abolished. We conclude that, early after MI, perturbations in myocardial oxygen balance are observed in remodelled myocardium. However, adaptive alterations in coronary resistance vessel control, consisting of increased vasodilator influences in conjunction with blunted vasoconstrictor influences, act to minimize the impairments of myocardial oxygen balance.

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Ischemic heart disease induce upregulation of endothelin receptor mRNA in human coronary arteries

Cited by 65 publications

References 32 publications

Cardiovascular risk factors regulate the expression of vascular endothelin receptors

Cardiovascular risk factors regulate the expression of vascular endothelin receptors

Vascular endothelin ETB receptor-mediated contraction requires phosphorylation of ERK1/2 proteins

Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction

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