Ischemic heart disease in children and young adults with congenital heart disease in Sweden

Fedchenko, Maria; Mandalenakis, Zacharias; Rosengren, Annika; Lappas, Georg; Eriksson, Peter; Skoglund, Kristofer; Dellborg, Mikael

doi:10.1016/j.ijcard.2017.06.120

Cited by 32 publications

(37 citation statements)

References 26 publications

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“…16 Several studies have reported a high burden of cardiovascular There is a growing body of evidence that patients with congenital heart disease have a higher prevalence of ischemic heart disease compared with controls. 7,39 This is considered to be related to the cardiovascular risk factor burden rather than the congenital heart condition itself. 16…”

Section: Discussionmentioning

confidence: 99%

“…The number of adults with congenital heart disease (ACHD) is growing and an increasing amount of patients with congenital heart disease reach middle age and even older ages . With increasing age, these patients have an increasing risk of developing acquired cardiovascular disease, such as ischemic heart disease and stroke …”

Section: Introductionmentioning

confidence: 99%

“…However, Roifman et al showed that an increased risk of myocardial infarction in patients with CoA was associated with traditional cardiovascular risk factors and not with CoA itself . Further, a large registry study also showed that younger patients with CoA did not have a particularly increased risk of ischemic heart disease compared with patients with other congenital heart conditions …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] With increasing age, these patients have an increasing risk of developing acquired cardiovascular disease, such as ischemic heart disease and stroke. [7][8][9][10][11] Patients with coarctation of the aorta (CoA) have traditionally been assumed to have an increased risk of coronary artery disease, partly due to abnormal vascular reactivity and endothelial dysfunction. [12][13][14][15] However, Roifman et al showed that an increased risk of myocardial infarction in patients with CoA was associated with traditional cardiovascular risk factors and not with CoA itself.…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular risk factors in adults with coarctation of the aorta

Fedchenko

Mandalenakis

Dellborg

et al. 2019

Congenital Heart Disease

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Background The aging patient with adult congenital heart disease (ACHD) faces the risk of developing atherosclerotic disease. Patients with coarctation of the aorta (CoA) are especially vulnerable because of an inherent high risk of developing hypertension. However, data on the prevalence of other cardiovascular risk factors are scarce. Therefore, this study aimed to describe the prevalence of traditional cardiovascular risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity, and sedentary lifestyle) in adult patients with CoA. Methods Patients with CoA who were registered at the ACHD clinic in Gothenburg were asked to participate in a comprehensive cardiovascular risk assessment. This assessment included a glucose tolerance test, cholesterol profile, ambulatory blood pressure measurements, and a lifestyle questionnaire. Results A total of 72 patients participated. The median age was 43.5 years and 58.3% were men. Sixty‐six (91.7%) patients had ≥one cardiovascular risk factor and 40.3% had ≥three risk factors. Three (4.2%) patients were newly diagnosed with diabetes or impaired glucose tolerance. More than half of the patients had hyperlipidemia (n = 42, 58.3%) and 35 patients (48.6%) were overweight or obese. Only three (4.2%) patients smoked regularly. Of the 60 patients who underwent 24‐hour ambulatory blood pressure measurement, 33 (55.0%) were hypertensive. Of the 30 patients with known hypertension only 9 (30.0%) had well‐controlled blood pressure on ambulatory blood pressure measurement. Conclusions Cardiovascular risk factors among patients with CoA are prevalent. This may indicate a need for more aggressive screening strategies of traditional risk factors to minimize the risk of these patients also developing atherosclerotic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular risk factors in adults with coarctation of the aorta

Fedchenko

Mandalenakis

Dellborg

et al. 2019

Congenital Heart Disease

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“…Results from CONCOR are in line with the results of a study from the Royal Brompton Hospital, where systemic arterial hypertension and hyperlipidaemia were revealed as strong predictors of CAD 5 8. Even though in a recent study from the Swedish registry patients with congenital heart disease and CAD had less common a history of hypertension or diabetes mellitus compared with controls, it should be noted that this study refers to children and young adults (mean age 9.6±11.3 years) 11. Therefore, screening for traditional cardiovascular risk factors in the ageing ACHD population is as important as in the general population.…”

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confidence: 91%

Acquired cardiovascular disease in adult patients with congenital heart disease

Giannakoulas

Ntiloudi

2017

Heart

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Risk of Cancer Among Children and Young Adults With Congenital Heart Disease Compared With Healthy Controls

et al. 2019

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IMPORTANCEAdult patients with congenital heart disease (CHD) have an increased incidence of cancer, presumably owing to repeated radiation exposure, genetic predisposition, or repeated stress factors during heart interventions. However, there are limited data on the risk of cancer in children and young adults with CHD compared with the general population. OBJECTIVE To determine the risk of developing cancer from birth to age 41 years among patients with CHD compared with healthy matched controls. DESIGN, SETTING, AND PARTICIPANTS This registry-based, matched, prospective cohort study in Sweden used data from the Patient and Cause of Death Registers. Successive cohorts of patients

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Ischemic heart disease in children and young adults with congenital heart disease in Sweden

Cited by 32 publications

References 26 publications

Cardiovascular risk factors in adults with coarctation of the aorta

Cardiovascular risk factors in adults with coarctation of the aorta

Acquired cardiovascular disease in adult patients with congenital heart disease

Risk of Cancer Among Children and Young Adults With Congenital Heart Disease Compared With Healthy Controls

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