Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study.

Abstract

The Caerphilly Collaborative Heart Disease Study is based on a large cohort of men (2,398) aged 49-66 years at the time of study. Platelet aggregation induced by collagen, thrombin, and ADP was measured in fasting blood samples and was related to prevalent angina, past myocardial infarction, and electrocardiographic evidence of ischemic heart disease. A number of subjects had taken aspirin, other nonsteroidal anti-inflammatory drugs, or other drugs affecting platelet aggregation 7 days before blood sample collection; after the exclusion of these subjects, data were available for 1,811 men. No relations were demonstrated with angina, but significant relations were shown between past myocardial infarctions and electrocardiographic evidence of ischemia and ADP-induced aggregation (both primary and secondary) and between electrocardiographic evidence of ischemia and thrombin-induced aggregation. The strongest relation indicated more than a twofold increase in the odds of a past myocardial infarction in subjects of the highest fifth of ADP-induced primary platelet aggregation compared with the lowest fifth. No significant relations were detected with collagen-induced aggregation. Accounting for a number of possible confounding factors had a relatively small impact on the relations between platelet aggregation and ischemic heart disease. Other evidence, including the well-established effect of aspirin on reducing the incidence of ischemic heart disease, indicates that the relations we describe are unlikely to be simply an effect of IHD on platelets.

Effect of Acute and Chronic Tea Consumption on Platelet Aggregation in Patients With Coronary Artery Disease

“…53 Moreover, blood platelet counts and ADP-induced platelet aggregation have been shown to be related to CAD mortality, 40 and ADP-and thrombin-induced platelet aggregation has been associated with previous myocardial infarction. 41 The findings of the present study, however, suggest that the beneficial effect of tea and other flavonoid-containing foodstuffs on cardiovascular risk is unlikely to be explained by inhibition of platelet aggregation in patients with established CAD. The mechanism(s) of benefit warrant further investigation.…”

“…In the present study, we assessed ex vivo platelet aggregation in plateletrich plasma, a method that has been shown to relate to CAD mortality 40 and previous myocardial infarction. 41 In addition, we studied greater numbers of volunteers than the previous investigations. Importantly, our volunteers had known CAD and were taking aspirin and other cardiac medications that may affect platelet function, in contrast to the healthy volunteers in these previous reports.…”

Resveratrol, a Polyphenolic Compound Found in Wine, Inhibits Tissue Factor Expression in Vascular Cells

“…[1][2][3] However, it is unclear how the moderate consumption of red wine provides the protective effect against heart disease. Although the cardioprotective effects of most alcoholic beverages are probably because of ethanol-induced elevation of HDLs 35,36 and lowering of platelet aggregation, 37,38 factors other than ethanol in alcohol-containing beverages may also be responsible for the protective effect of alcoholic beverages. 7,39,40 Resveratrol, a phenolic compound found primarily in the skin of grapes and relatively abundant in red wine, has been thought to be one such factor because it has been shown to have antioxidant 6 and antiplatelet 8,14 activities.…”

Outcome of the Public consultation on the Draft Opinion of the Scientific Panel on Dietetic Products, Nutrition, and Allergies (NDA) on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol

“…Furthermore, n-6 PUFA increased urinary 11-dehydro-TXB2 excretion compared with saturated and monounsaturated fatty acids, which seemed to reflect an ADP-induced platelet aggregation (Lahoz et al, 1997;Thijssen and Mensik, 2005). Increased ADP-induced platelet aggregation is associated with increased atherosclerotic risk (Elwood et al, 1991;Thijssen and Mensik, 2005). , 2007).…”