Ischemic colitis associated with hormonal contraceptive treatment delivered via vaginal ring

Solís‐Muñoz, Pablo; Muñoz-Yagüe, M. T.; Rodríguez-Gil, Yolanda; Colina, Francisco; Solı́s-Herruzo, José A.

doi:10.4321/s1130-01082013000100016

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 IC predominantly affects young women, who are on hormonal contraceptives, particularly estrogen, being implicated. 2 Although estrogen dose correlates with venous thromboembolism risk, progesterone's direct correlation remains uncertain. 4 Hormonal contraceptives heighten coagulation factors, platelet aggregation, and fibrinogen levels, inducing hypercoagulability.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Progesterone-Only Contraceptive-Induced Ischemic Colitis

Rajamanuri,

Garg,

Siddiqui

et al. 2024

ACG Case Rep J

View full text Add to dashboard Cite

Ischemic colitis (IC) occurs when there is a temporary lack of adequate blood supply to the intestines, particularly in vulnerable areas such as the splenic flexure and sigmoid colon, which lack sufficient collateral blood vessels. Although primarily seen in older individuals with atherosclerotic risk factors, IC can also be triggered by hormonal contraceptives in young women. Although estrogen-containing oral contraceptives are known to increase thromboembolic risk, the impact of progesterone is not well understood. We report a unique case of biopsy-confirmed IC in a previously healthy 30-year-old woman who presented with abdominal pain and bloody diarrhea 2 months after initiation of progesterone-only oral contraceptive. This occurrence, although rare, underscores the need for further research on the impact of progesterone on coagulation, especially concerning mesenteric arteries.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Young women may experience ischemic colitis (IC) because of hormonal therapy's prothrombotic effects. 2 Users of combined oral contraceptives undergo several blood protein changes, such as increased levels of factors II, VII, VIII, and X, along with fibrinogen. Furthermore, there is a decrease in antithrombin and protein S levels.…”

Section: Introductionmentioning

confidence: 99%

Progesterone-Only Contraceptive-Induced Ischemic Colitis

Rajamanuri,

Garg,

Siddiqui

et al. 2024

ACG Case Rep J

View full text Add to dashboard Cite

show abstract

“…Colon ischaemia can occur in patients for whom the oral contraceptive pills are the only risk factor, but in younger patients, a second risk factor is usually present, such as a co‐morbid medical condition or another medication associated with colon ischaemia, increasing their risk. The mode by which oral contraceptive pills are administered seems not as important as the agent itself; vaginal rings have also been reported to be associated with colon ischaemia …”

Section: Pharmacologic Agents Strongly Associated With Colon Ischaemiamentioning

confidence: 99%

Review article: the pharmacological causes of colon ischaemia

Vodusek

Feuerstadt

Brandt

2018

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the colon, and may present with a range of symptoms. Diagnosis can be challenging due to symptom overlap with other conditions, varied aetiology, and often rapid and self‐resolving course. Aim To review comprehensively the literature regarding the pharmacological aetiologies of colonic ischaemia to enhance the understanding of the various mechanisms of disease, presentations, distribution, and outcomes. Methods A PubMed search for “colon ischaemia” and “ischaemic colitis” alone as well as in combination with various known pharmacologic causes was performed. Only the highest quality and relevant literature was included in this review. The quality of the literature for each association was rated by the authors and a consensus was made when discrepancies were encountered. Only associations that were deemed “moderate” or “strong” were included. Results The literature considering pharmacologically associated colonic ischaemia is diverse, lacks codification and is characterised by numerous case reports and case series. Constipation‐inducing drugs, digoxin, hormonal therapies, illicit drugs, immunomodulators, laxatives, and NSAIDs were strongly associated with colonic ischaemia. Antimicrobials, appetite suppressants, chemotherapies, decongestants, diuretics, ergot alkaloids, serotonin agents, statins, and vasopressor agents were moderately associated. Conclusions Patients presenting with abdominal pain, diarrhoea, or bloody stool need to be evaluated for the possibility of this condition and treated accordingly. Timely diagnosis is necessary to improve patient outcomes. This review aims to increase awareness among clinicians regarding the presentation of pharmacologically induced colonic ischaemia.

show abstract

Ethinylestradiol/etonogestrel

2013

Reactions Weekly

View full text Add to dashboard Cite

Ischemic colitis associated with hormonal contraceptive treatment delivered via vaginal ring

Abstract: We present the case of a young woman diagnosed with ischemic colitis associated with contraceptive hormonal therapy delivered via a vaginal ring. We have not found a similar case in the published literature. Case report

Cited by 3 publications

References 6 publications

Progesterone-Only Contraceptive-Induced Ischemic Colitis

Progesterone-Only Contraceptive-Induced Ischemic Colitis

Review article: the pharmacological causes of colon ischaemia

Ethinylestradiol/etonogestrel

Contact Info

Product

Resources

About