Ischemic cerebral stroke risk under psoriasis and psoriatic arthritis treatment: A real‐world observational study from the French national healthcare system database

Bulsei, Julie; Fontas, Éric; Hubiche, T.; Passeron, Thierry

doi:10.1111/jdv.19356

Cited by 1 publication

(1 citation statement)

References 7 publications

(7 reference statements)

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“…RCTs with longer follow‐up periods or further well‐designed longitudinal studies using data from national and international registers are necessary. For the novel IL‐23/Th‐17 axis inhibitors, although some studies have shown beneficial effects on the surrogate markers of CV diseases, 107,108 recently published observational studies suggest that IL‐12/23, IL‐17 and IL‐23 inhibitors might be associated with the risk of certain severe CV events 109–112 . Further comparative studies using real‐world data on the effect of different biological therapies of IMIDs on CV risk are needed.…”

Section: Discussionmentioning

confidence: 99%

Reducing cardiovascular risk in immune‐mediated inflammatory diseases: Tumour necrosis factor inhibitors compared to conventional therapies—A systematic review and meta‐analysis

Galajda,

Meznerics,

Mátrai

et al. 2024

Acad Dermatol Venereol

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Immune‐mediated inflammatory disease (IMID) patients including psoriasis, inflammatory arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) diseases compared to the general population. The increased CV risk may be promoted by tumour necrosis factor (TNF)‐α‐mediated immunological processes, which are present both in the pathomechanism of IMIDs and atherosclerosis. Our objective was to comprehensively investigate the effect of TNF inhibitors (TNFi) on CV risk compared with conventional therapies in IMIDs. The systematic literature search was conducted in three databases (MEDLINE, EMBASE, Cochrane Library) on 14 November 2022. Randomized controlled trials, cohort and case–control studies were eligible for inclusion. Outcomes consisted of the incidence of CV events, with major adverse cardiovascular events (MACE) as a main endpoint. A random‐effects meta‐analysis was performed by pooling fully adjusted multivariate hazard ratios (HR) and incidence rate ratios (IRR) with a 95% confidence interval (CI) comparing TNFis with conventional systemic non‐biologicals (CSNBs). Of a total of 8724 search results, 56 studies were included overall, of which 29 articles were eligible for the meta‐analysis, and 27 were involved in the systematic review. Including all IMIDs, the TNFi group showed a significantly reduced risk of MACE compared with the CSNB group (HR = 0.74, 95% confidence interval (CI) 0.58–0.95, p = 0.025; IRR = 0.77, 95% CI 0.67–0.88, p < 0.001). Subgroup analysis of Pso, PsA patients by pooling IRRs also confirmed the significantly decreased risk of MACE in TNFi‐treated patients compared with CSNB groups (IRR = 0.79, 95% CI 0.64–0.98). The observational nature of most included studies leading to high heterogeneity represents a limitation. Based on the results, TNFis may reduce the risk of CV events compared to CSNBs. Therefore, earlier use of TNFis compared to conventional systemic agents in the therapeutic sequence may benefit CV risk in IMID patients.

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Section: Discussionmentioning

confidence: 99%