Ischemic Amnesia

Michel, Patrik; Beaud, Valérie; Eskandari, Ashraf; Maeder, Philippe; Demonet, Jean-François; Eskioglou, Elissavet

doi:10.1161/strokeaha.117.017420

Cited by 45 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have proposed temporal lobe ischemia; 5–7 however, many other studies do not support this mechanism, and several major reasons have been presented. First, patients with TGA have no increased risk factors of cerebrovascular disease compared with healthy controls.…”

Section: Discussionmentioning

confidence: 98%

“…One patient's symptoms had not yet alleviated, but the patient had no obvious vascular abnormalities, indicating that vascular disease is a pathogenesis of TGA. Previous studies have proposed temporal lobe ischemia; [5][6][7] however, many other studies do not support this mechanism, and several major reasons have been presented. First, patients with TGA have no increased risk factors of cerebrovascular disease compared with healthy controls.…”

Section: Hippocampal Ischemia/infarctionmentioning

confidence: 96%

See 1 more Smart Citation

Transient Global Amnesia: Risk Factors, Imaging Features, and Prognosis

He¹,

Ye²,

Yang³

et al. 2021

NDT

View full text Add to dashboard Cite

Background and Aim: Transient global amnesia (TGA) was first described by Bender in 1956 and is characterized by sudden, temporary, and anterograde memory loss. This study aimed to explore the possible mechanisms of and lesions responsible for TGA. Methods: Retrospective data were collected from all patients with TGA admitted to Zhongshan Hospital, affiliated with Xiamen University, between October 1, 2011, and October 30, 2018. Information about the TGA condition, previous history, and clinical examination of the TGA and control groups was recorded. Functional magnetic resonance imaging was performed on the patients to explore the possible lesions responsible for TGA. Results: A total of 73 patients with TGA and 73 age-and gender-matched controls were included in the analysis. The differences in the migraine history (9/2, p = 0.038) were statistically significant in both groups, but no statistically significant difference was observed regarding the history of hypertension, diabetes, and other diseases. In addition, seven patients with TGA had lesions located in the hippocampal CA1 region; the dome column and hippocampal CA1 region exist in the same functional loop and play a synergistic role. The average follow-up period in the groups was 36 months. During the follow-up period, no significant differences in cerebral infarction, cerebral hemorrhage, CHD, or TGA attack between the groups were observed. Conclusion:Migraine may be a risk factor of TGA, and cerebral infarction may be one of the pathogeneses. The brain area responsible for TGA may involve a memory loop comprising the hippocampal CA1 region and the fornix column among other parts.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Hippocampal Ischemia/infarctionmentioning

confidence: 96%

Transient Global Amnesia: Risk Factors, Imaging Features, and Prognosis

He¹,

Ye²,

Yang³

et al. 2021

NDT

View full text Add to dashboard Cite

show abstract

“…Treatment for TGA remains supportive, given its self-limiting nature, with symptoms generally resolving within 24 h. Initial workup generally includes evaluation of multiple etiologies of altered mentation with imaging including an DWI sequence MRI for evaluation of ischemia. 10 Recurrent episodes of TGA remain somewhat rare. One retrospective cohort study found a recurrence rate of 13.7% and furthermore highlighted that migraines were more associated with recurrence.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Episodes of Transient Global Amnesia: A Rare Clinical Entity

Rao¹,

Allen²,

Blackwood³

et al. 2022

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

Transient global amnesia (TGA) is a syndrome characterized by anterograde amnesia with otherwise intact cognitive function, resolving within 24 h of onset, occurring in the absence of neurological changes. Recurrent episodes remain rare. We report an interesting case of recurrent episodes of TGA in a 63-year-old woman presenting with altered mental status. She had no memory of antecedent events and demonstrated repetitive questioning but retained awareness of self. Physical examination and laboratory diagnostics were unremarkable. Brain magnetic resonance imaging revealed scattered foci of increased FLAIR signal within the bilateral periventricular and subcortical white matter. She was notably diagnosed with TGA a few months prior when she had presented with similar symptoms. During the current hospitalization, she remained alert and fully oriented, with resolution of perseveration. This case emphasizes the recognition of TGA as an important neurological diagnosis, uniquely describes not only the recurrence, but the short interval between recurrent episodes.

show abstract

“…functioning independently. 42 Additionally, because multiple longterm outcome studies show no increased risk of subsequent strokes in patients diagnosed with TGA, isolated acute transient amnesia is very rarely due to stroke. 34,[36][37][38][39][40] Patients with strokes that involve the hippocampus usually involve other structures, including the ipsilateral occipital lobe, thalamus, and cerebral peduncle.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of diffusion‐weighted magnetic resonance imaging in transient global amnesia as a function of time from symptom onset

Wong

Silva

Gerberi

et al. 2021

Academic Emergency Medicine

View full text Add to dashboard Cite

Background:The objective was to systematically evaluate the sensitivity of diffusionweighted magnetic resonance imaging (DW-MRI) for transient global amnesia (TGA) across various time frames compared to the reference-standard clinical criteria.Methods: All indexed publications related to TGA and MRI through June 2020 were retrieved by a medical librarian. Two independent reviewers identified original research studies of adults with a clinical diagnosis of TGA using Caplan and Hodges and Warlow criteria (reference standard) who were evaluated with DW-MRI. Pooled estimates and its 95% confidence intervals (CI) for the proportion of acute TGA patients with positive DW-MRI (i.e., sensitivity) were obtained using random-effects metaanalysis for various time frames. Quality assessment was performed using the revised Quality of Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Results:After screening 665 reports, we identified 81 potentially relevant studies.Twenty-three studies representing 1688 patients met eligibility criteria, but not all studies had data available for meta-analysis. The pooled sensitivity (also described as positivity rate) of DW-MRI was 15.6% (95% CI = 2.6%-35.0%) between 0 and 12 h from symptom onset, 23.1% (95% CI = 6.1%-45.7%) at 0-24 h, 72.8% (95%

show abstract

Ischemic Amnesia

Abstract: Amnesia as the main symptom of acute ischemic cerebral events is rare, mostly transient, and easily mistaken for TGA. Although clinical clues are often present, the threshold for performing diffusion-weighted imaging in acute amnesia should be low.

Cited by 45 publications

References 16 publications

Transient Global Amnesia: Risk Factors, Imaging Features, and Prognosis

Transient Global Amnesia: Risk Factors, Imaging Features, and Prognosis

Recurrent Episodes of Transient Global Amnesia: A Rare Clinical Entity

Sensitivity of diffusion‐weighted magnetic resonance imaging in transient global amnesia as a function of time from symptom onset

Contact Info

Product

Resources

About