Ischemia-selective protection against cardiac ischemia/reperfusion injury by malonate

Prag, Hiran A.; Aksentijević, Dunja; Dannhorn, Andreas; Giles, Abigail; Mulvey, John M.; Sauchanka, Olga; Du, Lanying; Reinhold, Johannes; Xu, Zhelong; Pellerin, Luc; Goodwin, Richard J. A.; Murphy, Michael; Krieg, Thomas

doi:10.1016/j.yjmcc.2022.08.013

Cited by 1 publication

(1 citation statement)

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“…Furthermore, treatment of macrophages with the complex II inhibitor malonate increased intracellular succinate levels but had a modest impact on IL-1β release 43 . However, malonate is a negatively charged dicarboxylate with poor membrane permeability 44 . It is unclear how malonate enters the cell at neutral pH, what intracellular concentrations of malonate were achieved, or if it led to a significant impairment in mitochondrial respiration.…”

Section: Mitochondrial Bioenergeticsmentioning

confidence: 99%

Multifaceted mitochondria in innate immunity

Marques,

Kramer,

Ryan

2024

npj Metab Health Dis

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The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However, recent decades have seen an evolution in our understanding of mitochondria, highlighting their significance as key signal-transducing organelles with essential roles in immunity that extend beyond their bioenergetic function. Importantly, mitochondria retain bacterial motifs as a remnant of their endosymbiotic origin that are recognised by innate immune cells to trigger inflammation and participate in anti-microbial defence. This review aims to explore how mitochondrial physiology, spanning from oxidative phosphorylation (OxPhos) to signalling of mitochondrial nucleic acids, metabolites, and lipids, influences the effector functions of phagocytes. These myriad effector functions include macrophage polarisation, efferocytosis, anti-bactericidal activity, antigen presentation, immune signalling, and cytokine regulation. Strict regulation of these processes is critical for organismal homeostasis that when disrupted may cause injury or contribute to disease. Thus, the expanding body of literature, which continues to highlight the central role of mitochondria in the innate immune system, may provide insights for the development of the next generation of therapies for inflammatory diseases.

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Section: Mitochondrial Bioenergeticsmentioning

confidence: 99%