Ischemia-Reperfusion Injury is More Severe in Older Versus Young Rat Livers

Park, Yeonho; Hirose, Ryutaro; Coatney, John L.; Ferrell, Linda D.; Behrends, Matthias; Roberts, John P.; Serkova, Natalie J.; Niemann, Claus U.

doi:10.1016/j.jss.2006.08.013

Cited by 29 publications

(24 citation statements)

References 32 publications

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“…In humans, a low amount of allantoin is therefore formed by the chemical oxidation of low amounts of uric acid during oxidative stress, and in birds, the oxidation of relatively high amount of uric acid (originating from both purine metabolism and amino acid nitrogen detoxification) leads to relatively high levels of allantoin in serum. Consistent with this, allantoin concentration in the blood serum of adult rats is around 200 μmol/L (Park et al 2007); in humans, only around 20 μmol/L (Mikami et al 2000;Causse et al 2007) and in poultry, allantoin serum concentration is again relatively high, around 200 μmol/L (Simoyi et al 2003;Tsahar et al 2006;Carro et al 2010).…”

Section: Introductionsupporting

confidence: 62%

allB, allantoin utilisation and Salmonella enterica serovar Enteritidis and Typhimurium colonisation of poultry and mice

et al. 2011

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Natural variation in the presence or the absence of STM0517-0529 genes allowing allantoin utilisation has been described in field isolates of the multidrug resistant Salmonella enterica serovar Typhimurium belonging to the phage type DT104. Interestingly, S. enterica subspecies enterica serovar Typhimurium DT104 is quite frequent in pigs and cattle, but rarely present in egg-laying hens. Taking into account the different mode of allantoin metabolism in birds and mammals, we were interested in whether the absence of STM0517-0529 genes may disable this clone in poultry colonisation. We have therefore constructed the allB (also designated as STM0523) mutants in S. enterica subspecies enterica serovar Typhimurium and S. enterica subspecies enterica serovar Enteritidis, and with these, we infected mice, newly hatched chickens and adult egg-laying hens to show that the defect in allantoin utilisation does not influence S. enterica virulence for mice or adult hens, but slightly decreases virulence of S. enterica for chickens. The decrease in virulence of the allB mutant was relatively minor as it could be observed only after a mixed infection model, consistent with a lower prevalence, but not a total absence of such clones in poultry flocks.

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Section: Introductionsupporting

confidence: 62%

allB, allantoin utilisation and Salmonella enterica serovar Enteritidis and Typhimurium colonisation of poultry and mice

et al. 2011

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“…Aged livers in patients [1][2][3] and animal models [2,4] are more susceptible to IR injury than young livers. The results of some studies suggest that there is an increased risk of liver failure in patients receiving a graft from an older donor [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Intermittent Ischemia but Not Ischemic Preconditioning Is Effective in Restoring Bile Flow After Ischemia Reperfusion Injury in the Livers of Aged Rats

Schiesser

Wittert

Nieuwenhuijs

et al. 2009

Journal of Surgical Research

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“…This finding may be increasingly important given that aging increases IRI and as liver resections are more frequently performed on older patients than before (215).…”

Section: Ischemic Preconditioning (Ipc)mentioning

confidence: 94%

Methods to Reduce Liver Ischemia/Reperfusion Injury

Björnsson¹

2014

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Ischemia-Reperfusion Injury is More Severe in Older Versus Young Rat Livers

Cited by 29 publications

References 32 publications

allB, allantoin utilisation and Salmonella enterica serovar Enteritidis and Typhimurium colonisation of poultry and mice

allB, allantoin utilisation and Salmonella enterica serovar Enteritidis and Typhimurium colonisation of poultry and mice

Intermittent Ischemia but Not Ischemic Preconditioning Is Effective in Restoring Bile Flow After Ischemia Reperfusion Injury in the Livers of Aged Rats

Methods to Reduce Liver Ischemia/Reperfusion Injury

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