Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

Kosieradzki, Maciej; Rowińskí, W

doi:10.1016/j.transproceed.2008.10.004

Cited by 260 publications

(194 citation statements)

References 99 publications

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“…Exposure to previous insults that increase oxidative stress in the kidney may result in subsequent protection by up-regulated endogenous factors such as superoxide dismutase [10]. In this setting, exogenous antioxidants may only be beneficial during cer-tain time intervals, possibly because of activation of other mechanisms of cellular injury and death, such as inflammation, increased intracellular calcium and activetion of caspases [7] by hypoxemia and acidosis.…”

Section: Discussionmentioning

confidence: 99%

“…With the growing number of older kidneys being transplanted, this may become an even larger issue both in short-and long-term graft survival. With increasing age, donor kidneys are likely to harbor greater amounts of ischemic tissue and thus the transplanted kidney may be more susceptible to the more severe damaging effects of I/R injury [7]. In conjunction with this, older donor kidneys have fewer functional nephrons compared to younger donor kidneys accounting for a stronger chance of eventual graft dysfunction/rejection [8].…”

Section: Introductionmentioning

confidence: 99%

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Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury

Slyvka¹,

Nowak²,

Hayes³

et al. 2013

OJMIP

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Objectives: The process of transplantation is associated with exposure to both long and short cold and warm ischemic times that result in ischemia/reperfusion injury. Oxidative stress contributes to tissue fibrosis, renal dysfunction, and/or rejection. Treatments that scavenge oxygen free radicals and have antioxidant properties can ameliorate the damaging results in renal grafts following ischemia/reperfusion injury. The present study tests the hypothesis that an antioxidant-fortified diet given to rats before and after renal ischemia/reperfusion injury will reduce the kidney damage that results and improve renal function. Endothelial and inducible nitric oxide synthases may change with tissue injury, including ischemia/ reperfusion. Materials and Methods: Male Wistar rats were subjected to ischemia/reperfusion injury at 7 or 19 weeks of age with or without dietary antioxidant supplementation. One week later, glomerular filtration rate, mean arterial pressure and urinary nitric oxide were measured, and renal endothelial and inducible nitric oxide synthases examined. Results: The glomerular filtration rate was elevated more than two-fold above the normal range at 8 weeks in animals on the regular diet exposed to ischemia/reperfusion, while in the 8 week antioxidant-fortified diet group the glomerular filtration rate was normal. Also, in 8 week rats, levels of endothelial nitric oxide synthase protein in cortex were higher on the regular than on the antioxidant-fortified diet. Conclusion: Early after ischemia/reper-fusion injury renal endothelial nitric oxide synthase levels rise, possibly contributing to vascular dilation and hyperperfusion, and an antioxidant-fortified diet can ameliorate these changes in the younger age group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury

Slyvka¹,

Nowak²,

Hayes³

et al. 2013

OJMIP

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“…However, a long-time cold ischemia would be directly related to the severity of I/R injury following transplantation, particularly for allograft retrieved from extended criteria donors (14). I/R has been an inevitable event accompanying kidney transplantation, which may lead to a variety of cellular lesions, including disruption of cell polarization, disassembly of actin cytoskeleton organization, disruption of tight junctions, necrosis and apoptosis (3). Recent evidence markedly suggests that I/R injury may initiate ER stress leading to cellular phenotypic alterations and death (15).…”

Section: Discussionmentioning

confidence: 99%

“…However, problems involving ischemia/reperfusion (I/R) damage remain unresolved since, to date, the procedure of renal transplantation requires the grafted organ to go through phases of cold preservation and warm reperfusion (2). It has been reported that the storage conditions of the donor kidney may affect the consequences of I/R injury (3), and the development of better organ preservation methods is a major target which has attracted scientific consideration.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation

Zhang

et al. 2011

Mol Med Report

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Abstract. Renal preservation is a universal problem since ischemia/reperfusion (I/R) injury remains an unresolved issue during the procedure of renal transplantation. Tanshinone IIA, one of the effective components of the traditional Chinese medicine Danshen, was reported to exhibit a variety of biochemical activities, including protection against I/R injury. Therefore, identifying the specific molecular pathway mediating tanshinone IIA protection of renal preservation would be of great value to the patients concerned. In this study, rats were divided into two groups and the kidneys were isolated and preserved in two solutions separately, one with Celsior solution and the other with tanshinone IIA additionally added to the Celsior solution. The superoxide dismutase (SOD) activity and the quantity of malonaldehyde (MDA) were measured, the expression of CHOP and caspase-12 were assessed by immunohistochemistry staining, and real-time quantitative reverse transcription-polymerase chain reaction analysis was performed after 0, 24 and 48 h of preservation. A significant increase in the activities of SOD and a decrease in the quantity of MDA were observed in the kidneys preserved with tanshinone IIA at 24 and 48 h (P<0.01). The expression of CHOP and caspase-12 was lower in the kidneys preserved with tanshinone IIA at 24 and 48 h than that in the kidneys preserved with Celsior solution alone (P<0.05). The results suggest that the supplementation of tanshinone IIA in standard Celsior solution may significantly improve long-term kidney preservation. Attenuating oxidative stress injury and decreasing endoplasmic reticulum (ER) stress-mediated apoptosis may play a role in the protection of kidney hypothermic preservation.

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“…Kidneys are susceptible to alterations in oxygen supply in procedures of organ transplantation protocols, 2 particularly due to an increase in both reactive oxygen species and inflammatory response activation, and to the appearance of cell death, since susceptible, or early damaged cells, find the energy needed to carry out these processes at the time of reperfusion after transplantation. 3 Research into new protocols to define preconditioning conditions that could render an organ resistant to ischemic insults is an area that receives increasing interest, from which new concepts emerge. We hypothesized that cell cycle arrest using CDK inhibitors may allow cells to initiate a process to repair ischemia-induced early damage in kidney tissues to later prevent reperfusion-induced damage.…”

Section: Introductionmentioning

confidence: 99%

Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells

et al. 2014

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Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

Cited by 260 publications

References 99 publications

Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury

Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury

Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation

Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells

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