Ischemia-Reperfusion Injury in Cadaveric Nonheart Beating, Cadaveric Heart Beating and Live Donor Renal Transplants

Gok, MA; Shenton, BK; Pelsers, Maurice M.A.L.; Whitwood, Adrian C.; Mantle, D; Cornell, Christopher; Peaston, R; Rix, D.; Jaques, BC; Soomro, NA; Manas, DM; Talbot, David

doi:10.1016/s0022-5347(05)00170-9

Cited by 13 publications

(11 citation statements)

References 18 publications

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“…The current results suggest that severe ischemic damage may limit the regeneration process and result in a decreased proliferation of renal cells, which could be associated with persistent abnormalities in perfusion. These data are consistent with a recent study which showed that recovery was slower in NHBD transplants than in live donor transplants (7).…”

Section: Discussionsupporting

confidence: 93%

“…These changes were associated with improved kidney function, reduced DGF, and a lower rate of PNF. Recent studies showed that renal recovery from NHBD transplants continues for 3 mo after hospital discharge (7). In the pig model, renal recovery was delayed and was associated with increased protein excretion in the urine.…”

Section: Discussionmentioning

confidence: 99%

“…Kidneys from NHBD are exposed to warm ischemia (WI) followed by cold ischemia (CI), and free radical release from organ tissue is enhanced after reperfusion (4,7). Inflammatory response to renal IR injury (IRI) results in endothelial cell activation and injury, enhanced leukocyte adhesion, leukocyte entrapment, and a compromise in microvascular blood flow (3,27).…”

mentioning

confidence: 99%

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A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model

Doucet

Milin²,

Favreau³

et al. 2008

American Journal of Physiology-Renal Physiology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model

Doucet

Milin²,

Favreau³

et al. 2008

American Journal of Physiology-Renal Physiology

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“…Ischaemia-reperfusion injury consist of 2 injury mechanisms namely ischemia characterized as oncotic necrosis and reperfusion injury. In the clinical setting this damage may delay the recovery of renal function prolong or complicate postoperative recovery or precipitate immunological reactions involved in the subsequent rejection reaction42.…”

Section: Discussionmentioning

confidence: 99%

Non Heart-Beating Donors in England

Chaib

2008

Clinics

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Chaib E. Non heart-beating-donors in England. Clinics. 2008;63(1):121-34. When transplantation started all organs were retrieved from patients immediately after cardio-respiratory arrest, i.e. from nonheart-beating donors. After the recognition that death resulted from irreversible damage to the brainstem, organ retrieval rapidly switched to patients certified dead after brainstem testing. These heart-beating-donors have become the principal source of organs for transplantation for the last 30 years. The number of heart-beating-donors are declining and this is likely to continue, therefore cadaveric organs from non-heart-beating donor offers a large potential of resources for organ transplantation. The aim of this study is to examine clinical outcomes of non-heart-beating donors in the past 10 years in the UK as an way of decreasing pressure in the huge waiting list for organs transplantation. KEYWORDS:Transplantation. Liver. Kidney. Donors.The imbalance between supply of organs for transplantation and demand for them is widening all over the world. In the United Kingdom (UK) the figures are not different, by the end of December 2004 there were over 6000 people on the active waiting list for organ transplantation. Recent data suggest that over 400 of these people will die each year before a new organ becomes available.

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“…Ischemia time is one of the important factors impacting transplantation results [14,15]. Ischemia itself can cause severe damage because of the potential for a build-up of metabolic wastes.…”

Section: Discussionmentioning

confidence: 99%

Orthotopic Kidney Transplantation in Mice: Technique Using Cuff for Renal Vein Anastomosis

et al. 2013

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Mouse renal transplantation is a technically challenging procedure. Although the first kidney transplants in mice were performed over 34 years ago and refined some years later, the classical techniques of mouse renal transplantation required clamping both vena cava and aorta simultaneously and carry out suture anastomoses of the renal artery and vein in a heterotopic position. In our laboratory, we have successfully developed mouse orthotopic kidney transplantation for the first time, using a rapid “cuffed” renal vein technique for vessel anastomosis, wherein the donor’s renal vein was inserted through an intravenous catheter, folded back and tied. During grafting, the cuffed renal vein was directly inserted into the recipient’s renal vein without the need for the clamping vena cava and suturing of renal vein. This technique allowed for the exact transplantation of the kidney into the original position, compared to the classical technique, and has significantly shortened the clamping time due to a quicker and precise anastomosis of renal vein as described. This also allowed for a quicker recovery of the lower extremity activity, reduction in myoglobinuria with resultant kidney graft survival of 88.9%. Thus we believe that the cuffed renal vein technique simplifies microvascular anastomoses and affords important additional benefits.

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Ischemia-Reperfusion Injury in Cadaveric Nonheart Beating, Cadaveric Heart Beating and Live Donor Renal Transplants

Cited by 13 publications

References 18 publications

A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model

A p38 mitogen-activated protein kinase inhibitor protects against renal damage in a non-heart-beating donor model

Non Heart-Beating Donors in England

Orthotopic Kidney Transplantation in Mice: Technique Using Cuff for Renal Vein Anastomosis

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