Ischemia-modified albumin levels in cord blood: A case-control study in uncomplicated and complicated deliveries

Gugliucci, Alejandro; Hermo, Ricardo; Monroy, Carolina; Numaguchi, Masahide; Kimura, Satoshi

doi:10.1016/j.cccn.2005.06.014

Cited by 47 publications

(37 citation statements)

References 14 publications

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“…In this respect, higher cord blood IMA values were documented in complicated deliveries, indicating fetal distress and/or hypoxia [24]. Furthermore, elevated maternal serum IMA levels have been recently demonstrated in early normal pregnancy, supporting the hypothesis that normal trophoblast development is associated with a hypoxic intrauterine environment [25].…”

Section: Discussionmentioning

confidence: 98%

Cord Blood Ischemia‐Modified Albumin Levels in Normal and Intrauterine Growth Restricted Pregnancies

Iacovidou¹,

Briana²,

Boutsikou³

et al. 2008

Mediators of Inflammation

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Ischemia-modified albumin (IMA) is a sensitive biomarker of cardiac ischemia. Intrauterine growth restriction (IUGR) may imply fetal hypoxia, resulting in blood flow centralization in favour of vital organs (brain, heart, adrenals—“brain sparing effect”). Based on the latter, we hypothesized that cord blood IMA levels should not differ between IUGR and appropriate-for-gestational-age (AGA) full-term pregnancies. IMA was measured in blood samples from doubly-clamped umbilical cords of 110 AGA and 57 asymmetric IUGR pregnancies. No significant differences in IMA levels were documented between AGA and IUGR groups. IMA levels were elevated in cases of elective cesarean section (P = .035), and offspring of multigravidas (P = .021). In conclusion, “brain sparing effect” is possibly responsible for the lack of differences in cord blood IMA levels at term, between IUGR and AGA groups. Furthermore, higher oxidative stress could account for the elevated IMA levels in cases of elective cesarean section, and offspring of multigravidas.

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Section: Discussionmentioning

confidence: 98%

Cord Blood Ischemia‐Modified Albumin Levels in Normal and Intrauterine Growth Restricted Pregnancies

Iacovidou¹,

Briana²,

Boutsikou³

et al. 2008

Mediators of Inflammation

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show abstract

“…Therefore, infants with RDS expose to severe hypoxia [4]. Current studies have determined that cord blood levels of IMA are higher in perinatal asfixia and complicated deliveries associated with fetal distress, hypoxia, and oxidative stress in newborns [11,12,19,20], and IMA has been declared to be a good marker for diagnosis of asphyxia. RDS is known a severe disease that leads to severe hypoxia and further deleterious neurodevelopmental outcomes of preterm infants and mortality without appropriate respiratory support and surfactant therapy.…”

Section: Discussionmentioning

confidence: 99%

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

et al. 2015

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Infants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P \ 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P \ 0.001; 95 % CI, 0.88-0.98) in the receiver operating characteristic curve.We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.

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“…There have been reports of elevated IMA in a range of other conditions where cardiac ischaemia and troponin elevation may also occur, including acute stroke,56 57 pulmonary embolus,58 polytrauma,58 end-stage renal disease,59 60 vascular52 and non-vascular surgery 61. More intriguingly, IMA elevations occur in obstetric conditions associated with placental ischaemia 62 63. IMA elevation may not be specific for cardiac ischaemia, However, there is also a large and ever increasing number of clinical conditions apart from ACS where cardiac troponin is elevated 64…”

Section: Cardiospecificitymentioning

confidence: 99%

Ischaemia-modified albumin: clinical utility and pitfalls in measurement

Collinson

Gaze

2008

J Clin Pathol

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Ischemia-modified albumin levels in cord blood: A case-control study in uncomplicated and complicated deliveries

Cited by 47 publications

References 14 publications

Cord Blood Ischemia‐Modified Albumin Levels in Normal and Intrauterine Growth Restricted Pregnancies

Cord Blood Ischemia‐Modified Albumin Levels in Normal and Intrauterine Growth Restricted Pregnancies

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

Ischaemia-modified albumin: clinical utility and pitfalls in measurement

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