Ischemia-modified albumin levels in cerebrovascular accidents

Gunduz, Abdülkadir; Türedi, Süleyman; Menteşe, Ahmet; Altunayoglu, Vildan; Turan, İbrahim; Karahan, Süleyman Caner; Topbaş, Murat; Aydın, Murat; Eraydin, Ismet; Akcan, Buket

doi:10.1016/j.ajem.2007.11.023

Cited by 118 publications

(95 citation statements)

References 18 publications

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“…However, a change in IMA levels does not only indicate cardiac pathology as IMA levels are also elevated in individuals with skeletal muscle ischemia [14,15]. The study by Troxler et al [16] [19]. However, in a study that evaluated IMA as a marker of oxidative stress in patients with beta thalessemia, IMA values were 0.725 in the thalessemia group and 0.554 in the control group [10].…”

Section: Discussionmentioning

confidence: 90%

“…The gender distribution is 50.1 % female and 49.9 % male. In order to determine the distribution according to the age groups, we divided the population by age group (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), 25-29, … 90-+) and stratified the subjects. Table 1 provides the distribution of reference, targeted and reached population according to the age groups.…”

Section: Study Population and Samplementioning

confidence: 99%

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The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

Duman¹,

Bakar²,

Eşsizoğlu³

et al. 2014

Turk J Bioch

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The reference values of ischemia modified albumin levels in healthy people admitted to a university hospital [ Methods: This study was performed on 582 people over 15 years old and healthy in appearance who had presented at the Çanakkale Onsekiz Mart University Faculty of Medicine Research and Application Hospital. The year 2011 population of Turkey was taken as the reference in the distribution of the study group according to age group and gender. A survey which queried the demographic features and health problems was administered to the participants of the study and 9 cc venous blood was drawn. IMA levels were measured by using the spectrophotometric method defined by Bar-Or. The mean, standard deviation, median, minimum, maximum, and 2.5 % -97.5 % interval were used in order to detect the IMA reference values. Results: A total of 274 males (47.1 %) and 308 women (52.9 %) were studied. The mean IMA value of the examined group was 0.339 ± 0.093, and the median was 0.343 (Min-Max: 0.053-0.631), while the 2.5 % -97.5 % percentil values were 0.145 -0.530. Conclusion: Studies that indicate the reference levels of the IMA for the diagnosis of ischemic conditions are insufficient. Our study is expected to contribute to closing this gap. Key Words: Ischemia, Ischemia-modified albumin, Reference range Conflict of Interest: The authors do not have a conflict of interest regarding the subjects related to this manuscript. ÖZETAmaç: İskemi modifiye albumin (IMA) akut koroner sendromun tanısında potansiyel kullanımı olabilecek bir miyokardiyal iskemi belirtecidir. Bu çalışmada amacımız Çanakkale Onsekiz Mart Üniversitesi'ne başvuran 15 yaşın üzerindeki sağlıklı insanlarda IMA testinin referans değerlerini belirlemektir. Gereç ve Yöntemler: Bu çalışma Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Araş-tırma ve Uygulama Hastanesine başvuran 15 yaş ve üzeri ve görünürde sağlıklı 582 kişi üze-rinde gerçekleştirilmiştir. Çalışma grubunun yaş ve cinsiyet dağılımı belirlenirken 2011 yılı Türkiye nüfusu referans olarak alınmıştır. Katılımcılara demografik özelliklerinin ve sağlık problemlerinin sorgulandığı bir anket formu uygulandı ve 9 ml venöz kan alınmıştır. IMA düzeyleri Bar-Or tarafından tanımlanan spektrofotometrik metot kullanılarak ölçülmüştür. IMA referans değerlerini saptamak için ortalama, standart sapma, ortanca, minimum, maksimum ve % 2,5 -% 97,5 persentil değeri kullanılmıştır. Bulgular: Toplamda 274 erkek (% 47,1) ve 308 kadın (% 52,9) değerlendirildi. Çalışılan grupta ortalama IMA değeri 0,339 ± 0,093, ortanca değeri 0,343 (Min-Maks: 0,053 -0,631), % 2,5 -% 97,5 persentil değeri 0,145-0,530'dir. Sonuçlar: İskemik durumların tanısında IMA'nın referans değerlerini vurgulayan çalışmalar yetersizdir. Bizim çalışmamızın bu açığı kapatmaya katkıda bulunacağını beklemekteyiz. Anahtar Kelimeler: İskemi, İskemi Modifiye Albumin, Referans aralık Çıkar Çatışması: Yazarların makale konusu dâhilinde herhangi bir çıkar çatışmaları bulunmamaktadır.

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Section: Discussionmentioning

confidence: 90%

Section: Study Population and Samplementioning

confidence: 99%

The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

Duman¹,

Bakar²,

Eşsizoğlu³

et al. 2014

Turk J Bioch

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show abstract

“…IMA increases in myocardial ischemia, cancers, infections, end-stage renal disease, liver disease, and cerebral ischemia (2)(3)(4)(5)(6)(7)(8)(9)(10)16). This study shows that serum IMA levels increase even in the absence of hypoxia markers in patients undergoing GTC seizures and that serum IMA values are directly proportional to length of seizure.…”

Section: Discussionmentioning

confidence: 99%

“…The ACB test is a quantitative assay that measures IMA in human serum (2). Experimental and clinical studies have shown an increase in IMA levels in blood in various organ ischemias or injuries, particularly myocardial ischemia, and systemic ischemias (2)(3)(4)(5)(6)(7)(8)(9). One study of patients with PCI reported that IMA is not only a marker of the occurrence of an ischemic event, but also an indicator of the severity of ischemia (10).…”

Section: Introductionmentioning

confidence: 99%

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

et al. 2017

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Background/aim: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures. Materials and methods:A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group. The patients' IMA, albumin, and IMA/albumin values at hours 0 and 1 following the episode were compared with control group values.Results: IMA levels in the patient group were significantly higher at hour 1 compared to hour 0, and were also significantly higher than those of the control group levels at hour 1. In addition, the patient group IMA/albumin index value at hour 1 was significantly higher than the baseline value. IMA levels increased significantly with length of seizure. Conclusion:Although there were no markers of hypoxia in patients undergoing GTC seizures in this study, hypoxia was observed to develop, and this caused serum IMA levels to rise in line with seizure duration.

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“…Isc he mi a mo di fied al bu min (IMA) me a su re ment re fer red as al bumin co balt bin ding test (ACB) is a new bi o mar ker of car di ac isc he mi a, ske le tal musc le isc he mi a and ce reb ral isc he mi a. [13][14][15] To in ves ti ga te the cli ni cal uti lity of IMA as a se rum mar ker for MTBI, we attemp ted to eva lu a te the ro le of IMA in rats with clo sed he ad MTBI.…”

Section: Ischemia Modified Albumin Levels Following Mild Closed Head mentioning

confidence: 99%

Ischemia Modified Albumin Levels Following Mild Closed Head Trauma in the Rat

Çolak¹,

Duman²,

Bamaç³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Mild tra u ma tic bra in in jury (MTBI) is one of the most fre qu ent ne u ro logi cal da ma ge types in which comp lex physi o lo gi cal and bi oc he mi cal events oc cur in tra u ma ti zed are a. Re gi o nal isc he mi a can oc cur in the acu te pha se af ter tra u ma. Re cently, both cli ni cal and expe ri men tal stu di es ha ve shown that isc he mi a mo di fi ed al bu min (IMA) is one of the most pro mising blo od mar kers of isc he mi a. In this study, whet her se rum IMA va lu es can be used in rats as a mar ker for in trac ra ni al isc he mi a ca u sed by tra u ma is investigated. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Wis taral bi no adult rats we re uti li zed in this study. Rats we re ex po sed to MTBI by using a tra u ma de vice. Fron tal and pa ri e tal bra in tis su es we re ta ken for his to pat ho lo gi cal in ves ti ga ti on. Se rum IMA va lu es of tra u ma ti sed and con trol rats we re me a su red with the ACB (al bu min co balt bin ding) test. R Re e s su ul lt ts s: : Whi le the ab so lu te IMA va lu es we re 0.576 ± 0.048 for tra u ma gro up, it was iden ti fi ed as 0.568 ± 0.055 for con trol gro up. The re was no sta tis ti cally sig ni fi cant dif fe ren ce bet we en tra u ma and con trol gro ups in the me an va lu e of the IMA. In our his to pat ho lo gi cal analy sis, nec ro sis as soci a ted with hypo xi a in the ou ter la yers of bra in cor tex as a re sult of the tra u ma app li ed to rats, and ne u ron da ma ge in the in ner la yers of the cor tex we re ob ser ved. In ad di ti on, red ne u rons we re de tec ted in the bra in cor tex as a re sult of early sta ge ne u ron da ma ge as so ci a ted with isc he mi a. C Co on nc c l lu u s si i o on n: : We fo und that the re is no sig ni fi cant in cre a se in IMA le vels in rats with tra u ma sugges ting that this bi o mar ker wo uld not be use ful in de tec ting early isc he mic chan ges in MTBI.K Ke ey y W Wo or rd ds s: : Rats; cra ni o ce reb ral tra u ma Ö ÖZ ZE ET T A Am ma aç ç: : Ha fif trav ma tik be yin ha sa rı (HTBH) en sık gö rü len nö ro lo jik ha sar lar dan bi ri dir ve trav ma ti ze alan da komp leks fiz yo lo jik ve bi yo kim ya sal olay lar oluş tu rur. Böl ge sel is ke mi trav madan son ra ki akut faz da gö rül mek te dir. Son za man lar da kli nik ve de ney sel ça lış ma lar iske mi mo difi ye al bu min (IMA)'in, is ke mi de en umut ve ri ci kan be lir teç le rin den bi ri ol du ğu nu gös ter miş tir. Ça lış ma da rat lar da se rum IMA de ğer le ri nin trav ma so nu cu olu şan ka fa i çi is ke mi de be lir teç ola rak kul la nı lıp kul la nı la ma ya ca ğı araş tı rıl dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Araş tır ma da Wis tar-al bi no tü rü eriş -kin rat lar kul la nıl dı. Rat lar trav ma dü ze ne ği kul la nı la rak HTBH'a ma ruz bı ra kıl dı. His to pa ta lo jik araş tır ma için fron tal ve pa ri e tal be yin do ku la rı alın dı. Trav ma ti ze ve kon trol rat la rın se rum IMA de ğer le ri al bu min ko balt ...

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Ischemia-modified albumin levels in cerebrovascular accidents

Cited by 118 publications

References 18 publications

The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

Ischemia Modified Albumin Levels Following Mild Closed Head Trauma in the Rat

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