Ischemia-Modified Albumin in Relation to Exercise Stress Testing

Sbarouni, Eftihia; Γεωργιάδου, Παναγιώτα; Theodorakis, George; Kremastinos, Dimitrios Th.

doi:10.1016/j.jacc.2006.06.007

Cited by 46 publications

(42 citation statements)

References 11 publications

(8 reference statements)

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“…Second, a variety of physiological factors can affect the levels of IMA in the body. For example, short-term postprandial IMA elevation was demonstrated in an elegant study by Bhagavan et al (28) Despite growing evidence that supports a significant alteration of serum IMA levels during exercise in coronary artery disease patients (29), in a study of marathon runners (30), the serum IMA levels did not increase immediately after a marathon run, indicating that skeletal muscle ischemia during exercise does not affect serum IMA concentrations. Finally, although there is little information on diurnal variation in serum levels of IMA, Dominguez-Rodriguez et al (31) demonstrated a diurnal fluctuation with significantly higher levels at 02.00 h in ST-elevation myocardial infarction patients and no serum IMA diurnal variations in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

et al. 2016

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Objective Ischemia-mediated oxidative stress and inflammation have been reported to be important contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) is a novel marker generated under ischemic and oxidative conditions and may reflect disease activity in distinct disease states. Therefore, we investigated whether the serum IMA levels are affected in infertile PCOS patients. Methods Forty-six patients with infertile PCOS, 30 patients with unexplained infertility, and 31 age-and body mass index (BMI)-matched controls were included in this cross-sectional study. Biochemical parameters, serum IMA levels, and their correlations with serum testosterone and insulin resistance were determined for each subject. Results In patients with infertile PCOS, the serum IMA levels were significantly elevated (p=0.003) compared with unexplained infertility patients and controls. A correlation analysis suggested that the IMA levels only correlated with the serum free testosterone levels in PCOS patients (r=0.43, p=0.028). Conclusion Elevations in the serum IMA levels in infertile PCOS patients may suggest a possible additional role of oxidative stress mechanisms in disease pathophysiology. Moreover, correlation between serum IMA and testosterone levels may influence the quality of oocytes via alterations in the balance of critical follicular fluid factors in the follicular microenvironment.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

et al. 2016

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“…Different conclusions have been drawn from the literature depending on the hypothesis that myocardial ischemia induced by EST may affect the plasma level of biochemical markers and this condition may improve the diagnostic accuracy of EST. Myocardial ischemia and injury markers, such as cTn (13,15,16), glycogen phosphorylase BB (13), and IMA (17,18), were applied in these studies and controversial results were obtained in general. Additionally, a relationship was established between the existence of CAD and the measurement of biochemical markers reflecting myocardial stress, such as BNP and NT-proBNP, at various time intervals before and after EST (19,20).…”

Section: Discussionmentioning

confidence: 99%

Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Arı¹,

Tokaç²,

Alihanoğlu³

et al. 2011

Anadolu Kardiyol Derg

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Objective: Although, there has been great improvement on the diagnosis and early treatment of acute coronary syndromes, especially in terms of myocardial damage biochemical markers, we do not have a specific marker yet, for using the diagnosis of stable coronary artery disease (CAD). This study aimed to evaluate the relationship between CAD and the changes of heart-type fatty acid binding protein (H-FABP) levels before and after exercise stress testing (EST). Methods: A total of 47 patients were enrolled in this observational study. Of 47 patients, 21 had normal coronary anatomy; the remaining 26 patients had coronary lesions over 70% in at least one major coronary artery. All patients performed EST. Along with this, H-FABP levels before EST and at peak exercise, 1 st hour, 3 rd hour (3h), were measured in all patients. Differences among the measurements were evaluated through the Friedman test and Wilcoxon test, and the Bonferroni correction was applied to determine which measurement caused the difference. Results: Contrary to expectations, the means of the H-FABP values measured at particular intervals for each group tended to decline from the basal level to the 3h level. When the difference between the 3h measurement and the basal level was compared in each group, the decreasing was statistically significant in both groups (p<0.05). A statistically significant decrease at the 3h measurement compared to the basal level in the CAD group was more apparent than in the control group (2.790±2.569ng/ml vs. 0.837±2.070ng/ml, p=0.009). Conclusion: We found that H-FABP levels did not increase during EST and contrary to expectation, were inclined to decrease. We thought that decreasing H-FABP levels likely resulted from exercise-induced proteinuria. (Anadolu Kardiyol Derg 2011; 11: 685-91) Key words: Coronary artery disease, heart-type fatty acid binding protein, exercise stress testing 685 ÖZET Amaç: Akut koroner sendrom tanısı ve erken tedavisinde özellikle miyokardiyal hasar belirteçlerinde sağlanan ilerleme ile önemli bir mesafe alınmasına rağmen stabil koroner arter hastalığı (KAH) tanısında kullanılabilecek özel bir markır henüz yoktur. Bu çalışmada egzersiz stres testi (EST) öncesi ve sonrası H-FABP düzeylerindeki değişim ile koroner arter hastalığı arasındaki ilişki araştırılmıştır. Yöntemler: Gözlemsel çalışmamıza en az bir majör koroner arterinde %70 ve üzerinde darlığı olan 26 hasta ve koroner arterleri normal bulunan 21 hasta olmak üzere toplam 47 hasta alındı. Tüm hastalara EST yapıldı. Tüm hastalarda bazal, pik egzersiz, 1. saat ve 3. saatte H-FABP ölçümü yapıldı. Ölçümler arası farka Friedman Testi ile bakıldı, farkın hangi ölçümden kaynaklandığını bulmak için Bonferroni düzeltmeli Wilcoxon Testi kullanıldı. Bulgular: Her bir grupta belirlenen zaman aralığında ölçülen H-FABP değerleri ortalamaları beklenenin aksine bazaldan üçüncü saate azalma eğiliminde idi. Üçüncü saat ile bazal ölçümler arasındaki farklar (fark 3) grup içinde karşılaştırıldığında her iki grupta da azalma anlamlı idi (p<0.05). H...

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“…Serum levels of IMA increase in other diseases, such as acute stroke, pulmonary embolus, peripheral artery disease and end-stage renal disease [9,10,11,12,13]. In addition, various other conditions, such as exercise, acidosis, or dehydration, also contribute to elevation of IMA levels [14,15]. In contrast to the investigators supporting IMA as a prognostic factor for future cardiovascular events, several teams [16,17,18]reported that IMA was unable to predict serious cardiac outcomes in the short term in patients with potential acute coronary syndrome.…”

Section: Introductionmentioning

confidence: 99%

Ischemia-Modified Albumin: Is It a Reliable Diagnostic and Prognostic Marker for Myocardial Ischemia in Real Clinical Practice?

Kim

Hwang²,

Ko³

et al. 2010

Cardiology

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Objectives: We investigated whether ischemia-modified albumin (IMA), a novel biomarker of acute myocardial ischemia, is reliable for diagnosing ischemic chest pain and predicting future cardiac events in clinical practice. Methods: We enrolled 390 patients (age 61.7 ± 39.9 years) who arrived at the emergency department within 6 h of pain onset. We compared serum IMA levels of patients with ischemic chest pain (ICP) to those with nonischemic chest pain (NICP). Results: NICP was diagnosed in 162 patients and ICP in 205 patients. Median serum IMA levels did not differ between the NICP (99.0 U/ml; 95% confidence interval, 98.2–101.2 U/ml) and the ICP group (99.0 U/ml; 95% confidence interval, 99.4–102.6 U/ml; p = 0.320). During a 2-year follow-up, adverse cardiac events including cardiac death, myocardial infarction and recurrent angina occurred in 25 of 205 patients (12.2%) in the ICP group, but IMA was not predictive of cardiac events. Conclusions: IMA was neither able to discriminate acute chest pain due to myocardial ischemia from that of other origin nor to predict cardiac events. Therefore, use of serum IMA levels for triage of patients with acute chest pain does not seem effective in clinical practice.

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Ischemia-Modified Albumin in Relation to Exercise Stress Testing

Abstract: The IMA plasma levels change significantly during exercise testing in patients with coronary artery disease, but there is no difference between positive and negative stress tests; this possibly implies that the observed changes do not reflect myocardial ischemia.

Cited by 46 publications

References 11 publications

Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Ischemia-Modified Albumin: Is It a Reliable Diagnostic and Prognostic Marker for Myocardial Ischemia in Real Clinical Practice?

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