Ischemia-Modified Albumin in Gynecology

Kıncı, Mehmet Ferdi; Kasap, Burcu; Sivaslıoğlu, Ahmet Akın

doi:10.2217/bmm-2020-0616

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…The concentration of IMA in peripheral blood rises rapidly 5–10 minutes after myocardial ischaemia and continues to rise during the ischaemic process. Elevated serum levels of IMA can be detected earlier than other markers of myocardial injury such as creatine kinase isoenzymes, so the diagnosis of myocardial ischaemia can be made in time before myocardial necrosis by measuring serum IMA levels [ 21 ]. Besides, 70% of Lp-PLA2 hydrolysed and oxidatively modified low-density lipoprotein (ox-LDL) particles produce metabolites such as haemolytic lecithin and oxidised free fatty acids, which cause endothelial dysfunction, necrosis, and apoptosis through an inflammatory chain reaction, leading to atherosclerosis progression and plaque instability [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Serum IMA and LP-PLA2 Levels in Patients with Coronary Heart Disease and Their Correlation with the Degree of Myocardial Ischaemia and Their Diagnostic Value

Zhang

2022

Emergency Medicine International

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Purpose. To measure serum levels of ischaemia-modified albumin (IMA) and lipoprotein-associated phospholipase A2 (LP-PLA2) in patients with coronary heart disease (CHD) and to analyse their correlation with the degree of myocardial ischaemia and their diagnostic value. Methods. A sample of 150 patients diagnosed with CHD by coronary angiography in our hospital from March 2019 to September 2021 was taken as the CHD group. The patients were divided into acute myocardial infarction (AMI) group (n = 52), unstable angina pectoris (UAP) group (n = 54), and stable angina pectoris (SAP) group (n = 44) according to the degree of myocardial ischaemia, and then 50 healthy physical examination patients were selected as the health group during the same period. Serum C-reactive protein (CRP), interleukin-6 (IL-6), IMA, and LP-PLA2 levels were measured in each group separately. Multiple ordered logistic regression was used to analyse the factors influencing the degree of myocardial ischaemia in patients with CHD. Pearson correlation was used to analyse the correlation between serum IMA, LP-PLA2 levels and serum CRP, IL-6 levels in CHD patients. The diagnostic value of IMA alone, LP-PLA2 alone, and in combination for CHD was analysed using receiver operating characteristic (ROC) curves. Results. In terms of serum CRP, IL-6, IMA, and LP-PLA2 levels, the CHD group was higher than the health group, the AMI and UAP groups were higher than the SAP and health groups, and the AMI group was higher than the UAP group ( P < 0.05 ). Multiple ordered logistic regression analysis showed that serum CRP, IL-6, IMA, and LP-PLA2 levels were all independent influences on the degree of myocardial ischaemia in patients with CHD ( P < 0.05 ). Pearson correlation analysis showed a positive correlation between serum IMA, LP-PLA2 levels and serum CRP, IL-6 levels in CHD patients ( P < 0.001 ). The area under curve (AUC) for serum IMA levels to predict myocardial ischaemia in patients with CHD was 0.754 (95% CI: 0.684–0.825), with a sensitivity of 61.3% and specificity of 84.0% when the best cut-off value was 0.453; the AUC for serum LP-PLA2 levels to predict myocardial ischaemia in patients with CHD was 0.747 (95% CI: 0.681–0.813), with a sensitivity of 62.0% and specificity of 82.0% when the optimal cut-off value was 0.440; and the AUC of IMA + LP-PLA2 for predicting myocardial ischaemia in patients with CHD was 0.892 (95% CI: 0.847–0.938), with a sensitivity of 86.7% and specificity of 80.0% when the optimal cut-off value was 0.667. The specificity was 80.0%. Conclusions. Serum IMA and LP-PLA2 levels are elevated in patients with CHD. Serum IMA and LP-PLA2 levels are closely related to the degree of myocardial ischaemia and its inflammatory level, and the combination of IMA + LP-PLA2 can improve the diagnosis efficacy of myocardial ischaemia in CHD patients.

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Section: Discussionmentioning

confidence: 99%

Serum IMA and LP-PLA2 Levels in Patients with Coronary Heart Disease and Their Correlation with the Degree of Myocardial Ischaemia and Their Diagnostic Value

Zhang

2022

Emergency Medicine International

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“…The relationship between IMA and gynecological disorders has been studied extensively for the last 10 years. Detailed analysis of literature data on IMA changes in the blood and follicular fluid due to gynecological pathologies, such as dysmenorrhea, endometriosis, polycystic ovary syndrome (PCOS), uterine artery embolization, menopause, and infertility, is presented in the review of Kıncı et al [155]. Based on the analysis, the authors concluded as follows: (i) serum IMA may be useful in evaluating dysmenorrhea severity; (ii) follicular IMA provides information about the state of oocytes and embryo quality in vitro fertilization; (iii) the diagnostic significance of IMA in polycystic ovary syndrome is contradictory and require further research.…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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“…The formation of ischemia-modified albumin (IMA) was retraced to the destruction of the amino acid sequence of albumin by massive free radicals produced in oxidative stress response, leading to the alteration of its binding ability with transition metals [ 15 ]. IMA was extensively chosen as one biomarker to diagnose myocardial ischemia accompanied by the oxidative stress response [ 16 , 17 ]. Cardiac troponin I (cTn I), one gold standard for the determination of myocardial ischemia, is extremely specific and sensitive to the diminutive myocardial injury, and effectively avoided the false positive of CK-MB caused by skeletal muscle damage in the clinic [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

An auxiliary strategy of partial least squares regression in pharmacokinetic/pharmacodynamic studies: A case of application of guhong injection in myocardial ischemia/reperfusion rats

Chen,

Li,

Shao

et al. 2024

Journal of Food and Drug Analysis

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Guhong injection (GHI) has been applied in the therapy of cardio-cerebrovascular disease in clinic, but there is no report about the pharmacokinetic/pharmacodynamic (PK/PD) research on GHI treating myocardial ischemia/reperfusion (MI/R) injury in rats. In this study, eight compounds of GHI in plasma, including N-acetyl-L-glutamine (NAG), chlorogenic acid (CGA), hydroxysafflor yellow A (HSYA), p -coumaric acid ( p CA), rutin, hyperoside, kaempferol-3-O-rutinoside, and kaempferol-3-O-glucoside, were quantified by LC-MS/MS. We discovered that the values of t 1/2β , k 12 , V 2 , and CL 2 were larger than those of t 1/2α , k 21 , V 1 , and CL 1 for all compounds. The levels of four biomarkers, creatine kinase-MB (CK-MB), cardiac troponin I (cTn I), ischemia-modified albumin (IMA), and alpha-hydroxybutyrate dehydrogenase (α-HBDH) in plasma were determined by ELISA. The elevated level of these biomarkers induced by MI/R was declined to different degrees via administrating GHI and verapamil hydrochloride (positive control). The weighted regression coefficients of NAG, HSYA, CGA, and p CA in PLSR equations generated from The Unscrambler X software (version 11) were mostly minus, suggesting these four ingredients were positively correlated to the diminution of the level of four biomarkers. E max and ED 50 , two parameters in PK/PD equations that were obtained by adopting Drug and Statistics software (version 3.2.6), were almost enlarged with the rise of GHI dosage. Obviously, all analytes were dominantly distributed and eliminated in the peripheral compartment with features of rapid distribution and slow elimination. With the enhancement of GHI dosage, the ingredients only filled in the central compartment if the peripheral compartment was replete. Meanwhile, high-dose of GHI generated the optimum intrinsic activity, but the affinity of compounds with receptors was the worst, which may be caused by the saturation of receptors. Among the eight analytes, NAG, HSYA, CGA, and p CA exhibited superior cardioprotection, which probably served as the pharmacodynamic substance basis of GHI in treating MI/R injury.

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Ischemia-Modified Albumin in Gynecology

Cited by 3 publications

References 33 publications

Serum IMA and LP-PLA2 Levels in Patients with Coronary Heart Disease and Their Correlation with the Degree of Myocardial Ischaemia and Their Diagnostic Value

Serum IMA and LP-PLA2 Levels in Patients with Coronary Heart Disease and Their Correlation with the Degree of Myocardial Ischaemia and Their Diagnostic Value

Ischemia-Modified Albumin: Origins and Clinical Implications

An auxiliary strategy of partial least squares regression in pharmacokinetic/pharmacodynamic studies: A case of application of guhong injection in myocardial ischemia/reperfusion rats

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