Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T

Roy, Debashis; Quiles, Juan; Aldama, Guillermo; Sinha, Manas; Avanzas, Pablo; Arroyo-Espliguero, Ramón; Gaze, David; Collinson, Paul; Kaski, Juan Carlos

doi:10.1016/j.ijcard.2004.05.042

Cited by 105 publications

(73 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to other studies, the specificity of IMA for ACS detection is limited. 25,30,33 In our study, the ROC curve did not show a cutoff value to discriminate patients according to the presence of ACS. The curve points lay fairly close to the diagonal line with numerous true and false positives.…”

Section: Discussioncontrasting

confidence: 86%

“…Previous studies have also found IMA levels higher than 85 UI ⁄ mL in the NICP group. 25,30,37 The test sensitivity was increased with a cutoff point of 85 UI ⁄ mL. According to other studies, the specificity of IMA for ACS detection is limited.…”

Section: Discussionmentioning

confidence: 86%

“…19,30 Statistical analyses were conducted using the STATA 10 software (StataCorp LP, College Station, TX). Statistics are reported as means with standard deviations and medians with interquartile ranges (IQRs).…”

Section: Discussionmentioning

confidence: 99%

“…In those studies, the patients were not ''all comers,'' and the prevalence of ACS was unusually high in contrast to the real-life situation in a big city ED. 25,30,[33][34][35] We included in our study patients who were more representative of the population admitted to the ED with chest pain. 36 Contrary to previous studies, we studied patients with episodes of chest pain (persistent or not) suggesting a diagnosis of ACS to the EP, evolving within 12 hours.…”

Section: Discussionmentioning

confidence: 99%

“…36 Contrary to previous studies, we studied patients with episodes of chest pain (persistent or not) suggesting a diagnosis of ACS to the EP, evolving within 12 hours. 25,30,33 In a study by Collinson et al, 33 patients with significant ECG changes, comorbidity requiring hospital admission, suspected or proven alternative source of chest pain requiring hospital admission, known CAD with unstable angina, and atypical clearly noncardiac chest pain were not included. 33 Thus, their patients were highly selected with a bias toward a high likelihood of an ACS diagnosis.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Charpentier

Ducassé

Cournot

et al. 2010

Academic Emergency Medicine

View full text Add to dashboard Cite

Objectives: Heart fatty acid-binding protein (h-FABP) and ischemia-modified albumin (IMA) have recently been evaluated, but to the best of our knowledge, no study has reported an analysis of these two markers for the detection of early myocardial infarction and myocardial ischemia in a large cohort of consecutive patients presenting to an emergency department (ED). This study evaluates the diagnostic accuracy and the clinical utility of h-FABP and IMA for non-ST-segment elevation acute coronary syndrome (ACS) diagnosis in the first hour of management in an ED.Methods: In a prospective 11-month study, 677 patients admitted to the ED with chest pain and suspected non-ST-segment elevation ACS were enrolled. On presentation, blood samples were obtained for the measurement of the biomarkers h-FABP (immunodetection with CardioDetect) and IMA (albumin cobalt-binding test). Two physicians, blinded to the results of the markers, independently categorized patients as having or not having non-ST-segment elevation ACS.Results: Of the 677 patients who were prospectively recruited, non-ST-segment elevation ACS was diagnosed in 185 (27.3%). While IMA was not predictive of the ACS diagnosis (odds ratio [OR] = 1.23; 95% CI = 0.87 to 1.81), h-FABP was predictive of ACS diagnosis (OR = 4.65; 95% CI = 2.39 to 9.04) with specificity at 96.8% (95% CI = 95.4% to 98.1%) and sensitivity at 13.5% (95% CI = 10.9% to 16.1%). However, h-FABP did not add significant additional information to a predictive model that included the usual diagnostic tools for non-ST-elevation ACS management (p = 0.40). Conclusions:In this study on a large cohort of patients admitted to an ED for chest pain, IMA and h-FABP did not provide valuable information for ACS diagnosis.

show abstract

Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Charpentier

Ducassé

Cournot

et al. 2010

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

Ischaemia‐modified albumin levels in newborn jaundice before and after phototherapy

Erdem

Kurban

Altunhan

et al. 2011

Cell Biochemistry & Function

View full text Add to dashboard Cite

The aim of our study was to assess the effect of phototherapy (PT) on ischaemia-modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full-term newborns. The study was performed on 36 full-term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of the babies were determined before and after PT, by a colorimetric assay. IMA levels before and after PT were found as 0.424 ± 0.290 and 0.531 ± 0.262 absorbance units, respectively. Although IMA levels after PT were slightly higher, the difference was not statistically significant (p > 0.131). MDA levels before and after PT were found as 8.4 ± 1.8 µmol/l and 9.4 ± 1.5 µmol/l, respectively. Serum MDA concentrations were significantly higher after PT than before PT (p < 0.000). In previous studies, conflicting findings have been reported about the effect of PT on oxidant and antioxidant systems. However, we have found no study investigating IMA levels in hyperbilirubinaemia in newborns before and after PT. Our results shows that PT does not affect IMA levels significantly. IMA increases as a result of oxidative stress. We believe that the lack of significant difference between our IMA levels before and after PT may resulted from hyperbilirubinaemia, which has antioxidant effect.

show abstract

Intérêt des biomarqueurs devant une douleur thoracique

Charpentier

Tourneret

Lauque

2012

Les Biomarqueurs en Médecine D’urgence

View full text Add to dashboard Cite

Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T

Cited by 105 publications

References 19 publications

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Clinical Assessment of Ischemia‐modified Albumin and Heart Fatty Acid–binding Protein in the Early Diagnosis of Non‐ST‐elevation Acute Coronary Syndrome in the Emergency Department

Ischaemia‐modified albumin levels in newborn jaundice before and after phototherapy

Intérêt des biomarqueurs devant une douleur thoracique

Contact Info

Product

Resources

About