Ischemia and Reperfusion Injury of the Rat Liver: The Role of Nimodipine

Chavez-Cartaya, R.; DeSola, Gilda Pino; Ramírez-Romero, Pablo; Calne, Sir Roy; Jamieson, Neville V.

doi:10.1006/jsre.1996.0032

Cited by 14 publications

(13 citation statements)

References 11 publications

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“…In this process, the lack of ATP leads to ATP-dependent calcium pump dysfunction, causing the intracellular calcium level to increase. This calcium overload triggers conversion of xanthine dehydrogenase to xanthine oxidase, causing the production of ROS [21]. Thus, inhibiting calcium influx prevents ROS formation.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

Heuvel

Bast

Ambergen

et al. 2012

Journal of Transplantation

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Background. Statins and other cardiovascular medication possess antioxidant capacity. It was examined whether chronic use of these medications protects from the development of ischemia-reperfusion (I/R) related complications after DIEP (Deep Inferior Epigastric Perforator Free Flap) surgery. This paper contains a literature study on the antioxidant working mechanisms of these drugs. Methods. Medical information of 134 DIEP patients (173 flaps) was studied from their medical files. Patient and operative characteristics were registered, as well as I/R related complications. Results. Of the group that didnot use statins, 16.3% developed complications versus 30.8% amongst patients that did use these drugs (P = 0.29). Amongst patients that chronically use other cardiovascular medication, 26.8% developed I/R related complications versus 14.4% of the patients without medication (P = 0.10). Conclusions. Chronic use of statins or other cardiovascular medication didnot decrease the occurrence of I/R related complications after DIEP surgery. Therefore, research should be aimed at evaluating short-term pre-treatment with statins.

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Section: Discussionmentioning

confidence: 99%

“…These beneficial effects were also demonstrated in I/R of rat liver [20]. Calcium antagonists have also demonstrated protective effects in I/R of the liver [21]. All these studies were carried out in animals; little research has been performed in humans in this area.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

Heuvel

Bast

Ambergen

et al. 2012

Journal of Transplantation

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“…The purpose of this study was to investigate the potentially protective effect of four different drugs, with different mechanisms of action over free radical-mediated injury, in the same experimental model of liver ischemia and reperfusion, using the same ischemic time, which has proven to effectively quantify reperfusion injury and to detect any significant protective or destructive effect of manipulations of the ischemia-reperfusion sequence [7,[9][10][11][12]. The biochemical effect of free radical scavengers in ischemia and reperfusion has previously been demonstrated and was also the setting in which the pharmacological agents utilized in this study were selected [5,6,[15][16][17][22][23][24]30,3240,42,43,46,[50][51][52][53][54].…”

Section: Discussionmentioning

confidence: 99%

“…1). The hepatic galactose elimination capacity test provides a quantitative expression of the functional liver cell mass [12).…”

Section: Discussionmentioning

confidence: 99%

Free radical scavengers to prevent reperfusion injury following experimental warm liver ischaemia. Is there a real physiological benefit?

et al. 1999

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Free radical scavengers have been utilized to prevent the consequences of ischemia, however, results do not seem conclusive. In our study we analyzed the blood flow, function, and histology of rat liver tissue after warm liver ischemia, in order to assess the effect of free radicals in liver reperfusion injury. N-acetyl cysteine (NAC), tocopherol, allopurinol, and superoxide dismutase (SOD), pharmacological agents expected to protect from injury mediated by free radicals, were investigated. Laser Doppler flowmetry and photometry were utilized to measure post-ischemic microcirculatory changes as an expression of ischemia-reperfusion injury in a model of segmental liver ischemia in the rat, with an ischemic time of 45 min. Galactose elimination capacity, ALT and histology were used to assess the functional and morphological consequences of ischemia after 24 h of reperfusion. The overall mean blood flow over 1 hour after reperfusion was of 33.9% (SD 11.2) of the normal, non-ischemic control. NAC (31.2 Yo SD 10.9) did not show any protective effect and in some cases the effect seemed to be negative. Tocopherol (41.7 % SD 5.1) marginally improved post ischemic liver tissue blood flow. Treatment with allopurinol did not show any beneficial effects (37.5 % SD 14.2). Only animals treated with SOD showed an improvement of the post ischemic liver microcirculation (57.9 Yo SD 14.4)(P < 0.001) and function. Only SOD produced statistically significant differences in galactose elimination capacity, compared with those of the ischemic control group. This moderately protective effect of SOD is encouraging, however, the relevance of all these compounds in a broader pathophysiological setting remains unproven.

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“…Calcium influx inhibition can be performed either by blocking sodium/proton exchanger or by inhibiting ROCCs [12]. Protective effects of calcium antagonists against calcium overload in hepatocytes have been investigated in vitro [13][14][15] and in vivo [16][17][18]. Brecht and de Groot [19] have reported that calcium channel blockers largely improved the energetic situation of the hepatocytes under hypoxic injury.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Calcium Influx during Hypoxia/Reoxygenation in Primary Cultured Rat Hepatocytes

Crénesse¹,

Hugues

Ferre

et al. 1999

Pharmacology

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Calcium has been demonstrated to play an important role in hepatocyte damage during ischemia/reperfusion phases. Calcium influx was determined in primary cultured rat hepatocytes submitted to a succession of warm hypoxia and reoxygenation phases in the presence of diltiazem, gallopamil and a Na⁺/H⁺ antiport inhibitor, HOE-694. Only diltiazem significantly inhibited calcium influx with higher potency after reoxygenation than after hypoxia only, suggesting a complex mechanism of action of diltiazem which could act on different physiological functions involved in Ca²⁺ invasion of hepatocytes after hypoxic insult.

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Ischemia and Reperfusion Injury of the Rat Liver: The Role of Nimodipine

Cited by 14 publications

References 11 publications

The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

Free radical scavengers to prevent reperfusion injury following experimental warm liver ischaemia. Is there a real physiological benefit?

Inhibition of Calcium Influx during Hypoxia/Reoxygenation in Primary Cultured Rat Hepatocytes

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