Ischämietoleranz unter intrakoronar verabreichtem Nifedipin während transluminaler Koronarangioplastie

Hombach, Vinzenz; Höpp, H. W.; Behrenbeck, D. W.; Fuchs, Mary Anne; Osterspey, A.; Hilger, H H

doi:10.1007/978-3-642-70582-3_12

Cited by 4 publications

(2 citation statements)

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“…injections of calcium antagonists [11,17,21] and betablockers [23] have been administered prior to percutaneous transluminal coronary angioplasty (PTCA) to delay the onset of ischemia-related symptoms and ischemic indices. In clinical studies, however, it is very difficult to determine to * Supported by a grant from the Deutsche Forschungsgemeinschafl, SFB 330, Organprotektion.…”

Section: Introductionmentioning

confidence: 99%

The effect of intracoronary diltiazem on regional myocardial function and development of infarcts in porcine hearts

et al. 1989

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The effect of intracoronary (i.c.) pretreatment with diltiazem on regional myocardial function and the development of infarcts was investigated in regionally ischemic, reperfused porcine hearts. The left anterior descending coronary artery (LAD) was distally ligated in 16 pigs for 20-90 min followed by 24 h of reperfusion. Eight pigs were treated with increasing doses of i.c. diltiazem (0.375 mg/min, 0.75 mg/min, 1 mg/min) prior to ischemia. Eight pigs served as controls. Regional myocardial function was assessed by implanted ultrasonic crystals. Infarct size was determined as ratio of infarcted (tetrazolium stain) to ischemic myocardium (dye technique). I.c. diltiazem mainly depressed early systolic shortening (isovolumetric contraction) and lengthening during the first half of diastole. Pretreatment with this calcium antagonist significantly delayed the development of infarcts. In control experiments, a mean infarct size of 74% was found after 45-min ischemia. At that time no infarction was observed in the treated group, where infarcts started to evolve after 60-min ischemia. It is concluded that the favorable action of i.c. diltiazem can mainly be ascribed to a reduced myocardial oxygen consumption at the onset of ischemia.

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Section: Introductionmentioning

confidence: 99%

The effect of intracoronary diltiazem on regional myocardial function and development of infarcts in porcine hearts

et al. 1989

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“…Regional myocardial protection with calcium antagonists, especially with nifedipine [1,2] and diltiazem [3], and with beta-blockers [4] have been used prior to coronary angioplasty to delay the onset of ischemia-related symptoms. About 5% of the patients treated by angioplasty experience as a major complication an acute occlusion of the coronary artery, which is due to dissection, spasm, or thrombosis [5][6][7].…”

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confidence: 99%

Comparative study on the enhancement of ischemic tolerance by intracoronary pretreatment with three calcium antagonists in pig hearts

Klein

Pich

Lindert

et al. 1989

Cardiovasc Drug Ther

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The effect of intracoronary (IC) pretreatment with different calcium antagonists (diltiazem, nifedipine, verapamil) on the development of infarcts was investigated in two experimental series including 35 open-chest pigs. The left anterior descending coronary artery (LAD) was distally ligated for 75 minutes (series A) or for 45 minutes (series B) and was reperfused for 24 hours. Infarct size was determined as the ratio of infarcted myocardium (tetrazolium stain) to the risk region (dye technique). In series A, 20 pigs were pretreated immediately before occlusion with either IC diltiazem (n = 5, 4 mg/2 min), IC nifedipine (n = 5, 0.4 mg/2 min), IC verapamil (n = 5, 1 mg/2 min), or isotonic sodium chloride solution (n = 5). In series B, IC diltiazem (n = 5, 4 mg/2 min), IC verapamil (n = 5, 1 mg/2 min), or isotonic saline solution (n = 5) were administered 8 minutes prior to ischemia. The IC infusion of all calcium antagonists (series A) depressed left ventricular peak pressure, diastolic blood pressure, and dp/dt max and increased heart rate and coronary venous oxygen saturation. The development of infarcts was significantly delayed by IC diltiazem and IC verapamil. Mean infarct sizes (series A) amounted to 62% in the diltiazem group, 88% in the nifedipine group, 40% in the verapamil group, and 94% in the control group. In series B, where a time period of 8 minutes elapsed between pretreatment and induction of ischemia, mean infarct sizes after 45 minutes of ischemia and 24 hours of reperfusion amounted to 47% in the diltiazem group, 4% in the verapamil group, and 76% in control experiments.(ABSTRACT TRUNCATED AT 250 WORDS)

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Influence of anti-ischemic drug treatment on the ischemic response to acute coronary occlusion in man

Simon¹,

Herrmann²,

Amende³

et al. 1990

Developments in Cardiovascular Medicine

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Ischämietoleranz unter intrakoronar verabreichtem Nifedipin während transluminaler Koronarangioplastie

Cited by 4 publications

References 4 publications

The effect of intracoronary diltiazem on regional myocardial function and development of infarcts in porcine hearts

The effect of intracoronary diltiazem on regional myocardial function and development of infarcts in porcine hearts

Comparative study on the enhancement of ischemic tolerance by intracoronary pretreatment with three calcium antagonists in pig hearts

Influence of anti-ischemic drug treatment on the ischemic response to acute coronary occlusion in man

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