Ischaemic stroke as an initial presentation in patients with COVID-19: evaluation of a case series in an emergency in Brazil

Oliveira, Isabella Bezerra; Pessoa, Mariana S L; Lima, Carla Fc; Holanda, Jorge Lb; Coimbra, P.

doi:10.1177/1971400920987357

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Also, patients admitted to the hospital with neurological symptoms without symptoms of COVID-19 may be diagnosed with COVID-19 in the tests performed. [18][19][20][21][22] In our study, it was observed that the majority of COVID-19-positive stroke patients were admitted to the hospital due to stroke and were diagnosed with COVID-19 through subsequent tests.…”

Section: Discussionmentioning

confidence: 70%

Clinical comparison of acute stroke cases with and without COVID-19

Barut,

Haki,

Barut

2024

Turkish Journal of Internal Medicine

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Background We aimed to assess acute stroke cases with and without coronavirus disease 2019 (COVID-19) positivity concerning clinical features and the number of hospitalizations acute stroke cases compared to the previous year. Methods Acute stroke patients with and without COVID-19 positivity, including those who were hospitalized in the neurology service and intensive care unit of tertiary healthcare center between 17 December 2020 and 31 January 2021 due to acute stroke, were included in this cross-sectional study. Results Mortality (p=0.042) and mechanical ventilation use (p=0.041) were more frequent in COVID-19-positive stroke patients compared to those without COVID-19. The most common type of stroke in COVID-19-positive acute stroke patients was ischemic stroke (69.23%). Additionally, stroke patients with COVID-19 had a significantly higher percentage of kidney disease compared to those without COVID-19 (p=0.009). We also observed that the number of acute stroke cases hospitalized in our hospital during the pandemic decreased significantly compared to the previous year (p=0.036). Conclusion Since the majority of our patients were diagnosed with COVID-19 after admission to the hospital due to stroke, it should be kept in mind that patients who apply to the hospital with stroke symptoms may also have COVID-19, even if they are asymptomatic.

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Section: Discussionmentioning

confidence: 70%

Clinical comparison of acute stroke cases with and without COVID-19

Barut,

Haki,

Barut

2024

Turkish Journal of Internal Medicine

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“…The extent to which pre-existing chronic liver conditions affect COVID-19 related complications remains to be elucidated. Smell and taste sensations as well as increased incidence of ischemic stroke have been observed in individuals with COVID-19 [14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection

Zhang

Verma

Feng

et al. 2021

Preprint

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The COVID-19 pandemic caused by SARS-COV-2 has had a devastating impact on population health. We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (ACE2, TMPRSS2, DPP4, and LY6E). We analyzed novel data from 2,012 ethnically diverse Africans, 15,997 individuals of European (7,061) and African (8,916) ancestry recruited by the Penn Medicine BioBank (PMBB), and comparative data from 2,504 individuals from the 1000 Genomes project. At ACE2 we identified 41 non-synonymous variants, found to be at low frequency in most populations. However, three non-synonymous variants were frequent among Central African hunter-gatherers (CAHG) from Cameroon, and signatures of positive selection could be detected on haplotypes encompassing those variants. We also detected signatures of positive selection for variants at regulatory regions upstream of ACE2 in diverse African populations. At TMPRSS2, we identified 48 non-synonymous variants, several of which are common in global populations, and 13 amino acid changes that are fixed in the human lineage after divergence from Chimpanzee. At DPP4 and LY6E most variants were rare in global populations indicating that purifying selection is acting at these loci. At all four loci, we identified common non-coding variants associated with gene expression that vary in frequency across global populations. By analyzing electronic health records from the PMBB we discovered genetic associations with clinical phenotypes, such as respiratory failure with ACE2 and upper respiratory tract infection with DPP4. Our study provides new insights into global variation at genes potentially affecting susceptibility to SARS-CoV-2 infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

Zhang

Verma

Feng

et al. 2021

Preprint

View full text Add to dashboard Cite

We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (ACE2, TMPRSS2, DPP4, and LY6E). We analyzed novel data from 2,012 ethnically diverse Africans and 15,997 individuals of European and African ancestry with electronic health records, and integrated with global data from the 1000GP. At ACE2, we identified 41 non-synonymous variants that were rare in most populations, several of which impact protein function. However, three non-synonymous variants were common among Central African hunter-gatherers from Cameroon and are on haplotypes that exhibit signatures of positive selection. We identify strong signatures of selection impacting variation at regulatory regions influencing ACE2 expression in multiple African populations. At TMPRSS2, we identified 13 amino acid changes that are adaptive and specific to the human lineage. Genetic variants that are targets of natural selection are associated with clinical phenotypes common in patients with COVID-19.

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Ischaemic stroke as an initial presentation in patients with COVID-19: evaluation of a case series in an emergency in Brazil

Cited by 4 publications

References 14 publications

Clinical comparison of acute stroke cases with and without COVID-19

Clinical comparison of acute stroke cases with and without COVID-19

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

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