Ischaemic related transitory left ventricular dysfunction in 201Tl gated SPECT

Abstract

Post-stress and at-rest LVEF are similar when all patients are considered but significant differences appear when patients are divided according to the results of the perfusion study. Normal and fixed defect patients have increased post-exercise LVEF. Patients with reversible defects have decreased LVEF, which is largely due to an increased ESV. Transitory left ventricular dysfunction is related to the presence of reversibility and may benefit from revascularization.

Evaluation of post-stress left ventricular dysfunction and its relationship with perfusion abnormalities using gated SPECT in patients with cardiac syndrome X

“…Instead of an increase, a decrease in stress LVEF may possibly be considered as impaired response to stress. This situation had been attributed to stunning according to some previously published studies [25][26][27][28][29][30][31][32][33][34][35][36]. In the present study we found a 4.4 ± 2.0% increase in mean SLVEF in group II (patients with normal perfusion), whereas 3.1 ± 3.0% and 6.0 ± 5.1% decreases were found in values of group I (cardiac syndrome X) and III (patients with ischaemia), respectively.…”

“…However, it is possible that, in patients with coronary artery disease after stress, LV dysfunction and transient cavity dilatation may develop and can last up to 45 min or even longer after stress [42]. In addition, some previous studies showed that PLVD to the G-SPECT images had been well correlated with myocardial perfusion abnormalities and degree of stenotic vessels in CAG in patients with coronary artery disease [25][26][27][28][29][30][31][32][33][34][35][36]. However, validity of this condition for patients with cardiac syndrome X has not been established.…”

“…Gated SPECT (G-SPECT) offers the potential advantage of combining information about myocardial function and perfusion without any extra cost, any discomfort and radiation risk to the patient [19][20][21][22][23][24]. In addition to the several previous studies, prolonged left ventricular dysfunction (WM abnormalities, LVEF and volume impairments) in post-stress G-SPECT images had been well correlated with myocardial perfusion abnormalities and degree of stenotic vessels in CAG in patients with coronary artery disease [25][26][27][28][29][30][31][32][33][34][35][36]. There are many studies in the literature that showed perfusion abnormalities in cardiac syndrome X patients using myocardial perfusion SPECT [5,6,[37][38][39][40].…”