Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation in lower-extremity surgery with unilateral pneumatic tourniquet application: A clinical pilot study

Abstract

Ischaemic preconditioning attenuates haemodynamic response and lipid peroxidation during lower-extremity surgery with unilateral tourniquet application.

Near infrared spectroscopy (NIRS) to assess the effects of local ischemic preconditioning in the muscle of healthy volunteers and critically ill patients

“…Data from humans are sparse. In a randomized trial of patients undergoing elective knee surgery under regional anesthesia, the oxygen and lactate contents in the femoral vein decreased significantly after local ischemic preconditioning using a tourniquet (Van et al, 2008). These authors did not measure flow to calculate VO 2 , but several studies have demonstrated, during ischemic arterial occlusion in the coronary, femoral or brachial arteries, that flow is increased during the period of reactive hyperemia, but returns to baseline values in 3 to 10 minutes (Ellins and Halcox, 2011;Engelke et al, 1996;Hayman et al, 2010;Krishnan et al, 2011;Olivecrona et al, 2004;Olivecrona et al, 2007).…”

Platonin Mitigates Acute Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

“…[1][2][3][4][5]. However, reperfusion of the acutely ischemic lower limb can, in turn, induce reperfusion injury and cause remote vital organ dysfunctions [1,6,7].…”

Interventions to reduce tourniquet‐related ischaemic damage in orthopaedic surgery: a qualitative systematic review of randomised trials

“…One study used both anaesthetic and antioxidant intervention (propofol and N‐acetyl‐cysteine) (Table ). Three studies used ischaemic pre‐conditioning (Table ) and one study used both ischaemic pre‐conditioning and antioxidant intervention (N‐acetyl‐cysteine) (Table ).…”

“…Four studies used ischaemic pre‐conditioning; all used the same method, namely three cycles each of 5 min of ischaemia and 5 min reperfusion before final inflation of the tourniquet (Table ). One study used both ischaemic pre‐conditioning and N‐acetyl‐cysteine, but proved ischaemic pre‐conditioning to have better protective effects against ischaemia–reperfusion injury than N‐acetyl‐cysteine; it has therefore been listed in the ischaemic pre‐conditioning group (Table ).…”