Ischaemia of the colon: An experimental study

Villiers, De

doi:10.1002/bjs.1800530604

Cited by 53 publications

(15 citation statements)

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“…An ischaemic event during fetal life or postnatally leading to injury of both mucosa and muscularis propria, and differences in the regenerative capacity between mucosa and muscle, in which mucosa rather than muscle regenerates, resulting in exclusive absence of the musculature 8 , 9. A noteworthy fact is that animal studies have not yet been successful in producing such a lesion 3.…”

Section: Discussionmentioning

confidence: 99%

Segmental absence of intestinal musculature (SAIM): a case report in an adult

Aldalati¹,

Phelan

Ibrahim

2009

Case Reports

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Segmental absence of intestinal musculature (SAIM) is a rare entity of uncertain aetiology. A case of SAIM in an adult is presented, and three other adult cases of SAIM are reviewed. Our case concerns a middle-aged man who underwent a Whipple's procedure for a suspected neoplasm in the head of the pancreas. At surgery, a redundant segment of proximal jejunum with multiple large diverticula was incidentally noted and resected. On histological examination, the small bowel segment showed focal extreme thinning of the muscularis propria, focally amounting to complete absence. A peritoneal biopsy was also submitted which showed changes consistent with an old thrombosed vessel.

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Section: Discussionmentioning

confidence: 99%

Segmental absence of intestinal musculature (SAIM): a case report in an adult

Aldalati¹,

Phelan

Ibrahim

2009

Case Reports

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“…For example, ischemia with reduced intestinal blood flow (9,(12)(13)(14)(15)(16), and serum hyperviscosity ( 17), may produce early changes in the intestinal microcir-culation leading to a loss of organization of the mucosal cells (9,17). Devascularized or clamped intestinal loops lead to ischemia, low intestinal oxygen levels, the destruction of enteric nerve plexi and ganglion cells as well as gross and histologic damage to the intestinal mucosa (18)(19)(20)(21). Some of these structural changes can be reversed with local in situ oxygen administration (22).…”

mentioning

confidence: 99%

Alterations in Jejunal Transport and (Na+-K+)-ATPase in an Experimental Model of Hypoxia in Rats

Lifshitz

Wapnir

Teichberg

1986

Experimental Biology and Medicine

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Hypoxia was induced by exposing rats to an atmosphere of 93% N2, 7% 0 2 for 4-48 hr. The animals became hypoxic as indicated by a decreased blood P,02 (mean f SEM: 48 k 10 mm Hg). Hypoxia was accompanied by metabolic acidosis (pH 7.22 k 0.02) and decreased serum bicarbonate levels (9.0 f 4.0 meq/liter). Hypoxic rats also showed evidence of tissue hypoxia; liver tryptophan oxygenase levels were increased to 2 1 f 2 nmole/min/mg protein. In the hypoxic animals there was decreased jejunal mucosal (Na'-K+)-ATPase activity and an inhibition of active intestinal transport of sodium, glucose. 3-0-methylglucose. galactose, tyrosine. phenylalanine, and glycine as determined by in vivo perfusion studies. Jejunal fructose transport. which has a large passive component, was unaffected by hypoxia. The electrolyte, carbohydrate. and amino acid transport alterations produced by hypoxia were seen in the absence of an effect on jejunal cell number, DNA synthesis, or cell turnover. There was also no evidence of histological or ultrastructural damage. Furthermore. studies with a luminal macromolecular tracer, horseradish peroxidase, indicated that the jejunal lumen-to-blood barrier to macromolecules was also unaltered in these hypoxic animals. In vitro local oxygenation of the jejunum, by bubbling of 95% 0 2 : 5 % C02, markedly improved sodium and glucose (but not 3-0-methylglucose) absorption in hypoxic rats and control rats. The (Na+-K+)-ATPase activity of the jejunal mucosa of hypoxic rats was significantly enhanced by the local bubbling of 95% 0 2 % C 0 2 . Overall. our data indicate that during relatively mild conditions of hypoxia there is an inhibition of jejunal (Na'-K')-ATPase activity and related transport processes that is prevented by in situ oxygenation. o

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“…Thus Boley, Schwartz, Lash, and Stemhill (1963), Boley, Krieger. Schultz, Robinson, Siew, Allen, and Schwartz (1965), de Villiers (1966) and Marston, Marcuson, Chapman, and Arthur (1969) have all studied the effects of devascularization of the large intestine, using different experimental models. and have attempted to correlate their findings with clinical experience.…”

mentioning

confidence: 99%

Functional and morphological response of the dog colon to ischaemia

Robinson¹,

Rausis²,

Basset³

et al. 1972

Gut

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SUMMARY Total ischaemia of loops of dog colon was induced by clamping all afferent arteries and the colonic wall for different periods of time.Net sodium transport across the mucosa is abolished after one hour's ischaemia, but Na+-K+-ATPase levels in microsomal suspensions from the mucosa only fall significantly after two hours' ischaemia.Studies on the functional and morphological recovery of colons subjected to three hours' ischaemia have disclosed an extremely heterogeneous response among the 24 dogs used. Although all parameters were non-existent 24 hours after the intervention, one colon revealed a morphological and functional recovery one week after the operation, whilst two, three, and three out of six recovered after two, three, and four weeks respectively. There was a good correlation between the functional and macroscopic appearance of these recovered loops, though histologically various degrees of disorganization of the mucosa were observed. Among the loops that had no function, there was also a considerable variation in their microscopic structures.

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Ischaemia of the colon: An experimental study

Cited by 53 publications

References 10 publications

Segmental absence of intestinal musculature (SAIM): a case report in an adult

Segmental absence of intestinal musculature (SAIM): a case report in an adult

Alterations in Jejunal Transport and (Na+-K+)-ATPase in an Experimental Model of Hypoxia in Rats

Functional and morphological response of the dog colon to ischaemia

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