Isatis tinctoria mediated synthesis of amphotericin B-bound silver nanoparticles with enhanced photoinduced antileishmanial activity: A novel green approach

Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity

“…Later they have successfully adsorbed amphotericin B over the previously formed biogenic AgNPs surface. 234 They observed a enhanced parasites activity of amphotericin B adsorbed silver nanoparticle (IC 50 value 2.43 mg ml À1 ) than biogenic nanoparticle (IC 50 value of 4.2 mg ml À1 ) against Leishmania tropica 234 at promastigotes stage. Kalangi et al has explored that miltefosine doped green synthesized AgNPs offer enhanced antileishmanial effect.…”

“…233 Aer malaria, it is the most prevalent infectious disease in terms of fatality and geographical distribution. 234 The most common forms of leishmaniasis are cutaneous, characterized by skin sores, and visceral leishmaniasis which affects several internal organs like spleen, liver etc. Limited availability of antileishmanial drugs, its high cost and continuum resistance over the available drugs makes the situation fatal.…”

Nanostructured delivery systems with improved leishmanicidal activity: a critical review

“…The study limitation is the lack of the information about the amount of AmpB loaded. 140 Among the inorganic nanomaterials, carbon compounds are attracting interest due to their excellent mechanical, thermal, and optical properties. Drugs may be covalently linked to carbon nanotubes (CNTs) or strongly absorbed by π-π stacking on their surface (eg, doxorubicin).…”

Differential effects of in vitro cultures of Linum usitatissimum L. (Flax) on biosynthesis, stability, antibacterial and antileishmanial activities of zinc oxide nanoparticles: a mechanistic approach

“…In agreement with our results, many studies have shown that the smaller the size of nanoparticles, the greater the efficacy in inhibiting the Leishmania parasites by producing more ROS. 78,79 Different types of metal and metal oxide nanoparticles are reported to generate a high level of ROS, which promote the process of apoptosis. 8,80,81 It is well known fact that the Leishmania parasite are highly sensitive to ROS and any drug/agent that could generate ROS would be a promising antileishmanial contender.…”