Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by Japanese encephalitis virus

Ogata, Akihiko; Hamaue, Naoya; Terado, Mutsuko; Minami, Masaru; Nagashima, Kazuo; Tashiro, Kunio

doi:10.1016/s0022-510x(02)00342-8

Cited by 32 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Selegiline revived the motor function of model rats [3]. Similar results were obtained by isatin, another endogenous MAO inhibitor [4]. The neuropathologic findings in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys are similar to those with Parkinson disease.…”

Section: Introductionsupporting

confidence: 59%

“…Inhibition of MAO-B increases catecholamine concentrations within the brain [3]. Motor activity of JEVinduced rats receiving isatin, an endogenous MAO-A and B inhibitor, or selegiline, a selective MAO-B inhibitor, was improved compared with untreated JEV-infected rats [3,4]. Both isatin and selegiline prevented the decrease in striatal DA levels in JEVrats.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus

et al. 2006

View full text Add to dashboard Cite

We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA) levels were significantly decreased in all JEV-infected rats. Norepinephrine concentration in brain regions in the 180-day group was significantly decreased in the medulla oblongata and hypothalamus as compared with the control and 90-day group. Tyrosine hydroxylase-positive neurons were significantly decreased in both JEV-infected rat groups. These results suggest that DA decrease and pathological changes in JEV-infected model rats persist for a long time, at least up to 180 days, and this model will be useful for the evaluation of new anti-parkinsonian agents.

show abstract

Section: Introductionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus

et al. 2006

View full text Add to dashboard Cite

show abstract

“…17,18 In fact, a group of investigators has used JEV to induce a Parkinson's disease model in rats, with the major resultant neuropathologic changes comprising neuronal loss and gliosis mainly confined to the substantia nigra pars compacta. [19][20][21][22] While it is not our intention to overemphasize our patient's neurofibrillary tangle formation, a few aspects caused us to reflect on its possible significance in this setting. Neurofibrillary tangles (NFTs) are seen in normal aging, but our patient was relatively young (41-years-old).…”

Section: Discussionmentioning

confidence: 99%

West Nile Virus Encephalomyelitis with Polio-like Paralysis & Nigral Degeneration

Schafernak

Bigio

2006

Can. j. neurol. sci.

View full text Add to dashboard Cite

West Nile virus (WNV) is a mosquito-borne RNA virus in the genus Flavivirus (family Flaviviridae), and a member of the Japanese encephalitis serological group which comprises eight virus species including Japanese encephalitis virus (JEV) and St. Louis encephalitis virus (SLEV), and two subtype viruses. 1 Although most cases of WNV infection are subclinical or result in a mild, self-limited febrile illness known as West Nile fever, a minority of patients (<1%) develop acute neurologic disease, which can be severe and even fatal. 1-3 West Nile virus meningitis and encephalitis are often associated with favorable outcomes, 2 but when infection results in spinal anterior horn cell destruction it can cause an irreversible acute flaccid paralysis or poliomyelitis-like syndrome. [4][5][6][7][8][9][10][11] Movement disorders including parkinsonism, tremor and myoclonus have also been described. 2,[12][13][14] We present the clinical and neuropathologic findings in a ABSTRACT: Background: Patients infected with West Nile virus (WNV) may develop acute neurologic disease, which can be severe or even fatal, including WNV meningitis, encephalitis, and an irreversible acute flaccid paralysis or poliomyelitis-like syndrome. Movement disorders have also been described. Report: We report combined neuronal loss, gliosis, and neurofibrillary tangle formation in the substantia nigra of a 41-year-old man with a history of WNV encephalomyelitis and poliomyelitis-like paralysis. Conclusions: Clinically our patient did not display parkinsonism, however, it is interesting to speculate whether, in the absence of the residual subacute poliomyelitis-like syndrome, the neuropathologic findings could have eventually evolved clinically into WNV-associated postencephalitic parkinsonism. RÉSUMÉ: Encéphalomyélite due au virus du

show abstract

“…1,2 Isatin's concentration in urine is to become a diagnostic marker for the clinical severity of Parkinson's disease in humans however electrophysiology, synthetic and metabolic pathways of isatin in human system are yet to be fully established. 3,4 The electrochemical determination of isatin 5 and other nitrogen heterocycles using various electrode systems 6,7 attain prominence in recent years. 3-Arylimino derivatives (Schiff bases) obtained by the condensation of aromatic amines with isatin are powerful anticonvulsant, antiviral, antibacterial and antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of electrochemical reduction of isatin and its synthesized Schiff bases at HMDE

Gupta

Sindal

2009

J Chem Sci

View full text Add to dashboard Cite

The electrochemical behaviour of a series of Schiff base i.e. 3-[5-phenylpyrazol-3-ylimino]indol-2-ones (IIa-e) synthesized by the reaction of various 5-substituted isatins with 3-amino-5-phenyl-pyrazole has been investigated and compared with corresponding isatin in dimethylformamide in 0⋅1 M LiCl using cyclic voltammetry at Hanging Mercury Drop Electrode. All synthesized Schiff bases exhibit a single irreversible two-electron reduction wave in contrast with the two discrete one-electron transfer reduction waves observed for isatin in this medium. Observation of a well-developed single reduction wave can be attributed to the higher basicity of the nitrogen species of the imine bond of Schiff bases, making proton abstraction as well as second electron transfer both rapid. The compounds are subjected to constant potential preparative electrolysis. The products are identified as secondary amines by spectroscopic methods. A mechanism for the electro-reduction process has been proposed. Kinetic parameters have also been calculated.

show abstract

Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by Japanese encephalitis virus

Cited by 32 publications

References 18 publications

Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus

Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus

West Nile Virus Encephalomyelitis with Polio-like Paralysis & Nigral Degeneration

A comparative study of electrochemical reduction of isatin and its synthesized Schiff bases at HMDE

Contact Info

Product

Resources

About