Is γ-glutamyl Transferase Activity a Potential Marker of Left Ventricular Function During Early Postmyocardial Infarction period?

Valjevac, Amina; Džubur, Alen; Nakas-Ićindić, Emina; Hadžović-Dzuvo, Almira; Lepara, Orhan; Kiseljaković, Emina; Jadrić, Radivoj

doi:10.2217/fca.11.43

Cited by 6 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed higher serum GGT levels associated with mortality in men and women in correlation with other studies (33)(34)(35)(36). In the subgroup analysis of survivors or non-survivors, we did not observe a relationship with a history of DM, HT, or coronary heart disease.…”

Section: Discussionsupporting

confidence: 88%

Prognostic Value of Serum Gamma-Glutamyltransferase, Calcium, and Inorganic Phosphorus Levels in Short-Term Mortality of Patients with Acute Coronary Syndrome

Ergen¹,

Erdenen²,

Müderrisoğlu³

et al. 2015

Istanbul Med J

View full text Add to dashboard Cite

Objective: Gamma-glutamyltransferase (GGT) may be considered as a biomarker of "oxidative stress" associated with glutathione metabolism and a possible "proatherogenic" marker because of its indirect relationship with the biochemical steps in the oxidation of low density lipoprotein cholesterol. Serum inorganic phosphorus (P) level is also suggested as an independent risk factor for cardiac events and mortality in the long term. We aimed to observe the relationship of serum GGT, calcium (Ca), and P levels with 1 months' mortality after myocardial infarction.Methods: Our retrospective study included 200 patients (124 men and 76 women) with acute coronary syndrome (ACS) who were admitted to our hospital. We excluded subjects with severe systemic illness, hepatobiliary disease, alcohol consumption, chronic metabolic bone disease, malignancy, parathyroid disease, and patients who had a glomerular filtration rate (GFR) <60 mL/min. Fasting blood samples were taken in the first 24 h of admission to the coronary care unit (CCU). Reference values for GGT (9-36 U/L, for women; 12-64 U/L, for men), Ca (8.4-10.2 mg/dL), and inorganic P (≤4.5 mg/dL) were used. When the serum albumin level was <4.0 g/dL, corrected Ca levels were calculated using the equation [corrected Ca=measured Ca+(0.8×(4-serum albumin)]. Statistical analysis was performed using SPSS for Windows 10.0. Descriptive statistical analysis, Student's t-test, Mann-Whitney U-test, and chisquare test were used. Results:At the end of 1 month, we found significantly higher levels of blood GGT, P, and Ca×P products in patients who did not survive (n=23; 32.9 U/L, 3.66 mg/dL, 35.93 mg 2 /dL 2 ) than in survivors (n=177; 24.16 U/L, 3.27 mg/dL, 31.57 mg 2 /dL 2 ; p<0.001, p<0.001, p<0.001, respectively). Conclusion:Serum GGT, P, and Ca×P levels, even in the reference intervals, had a prognostic value in the short-term mortality apart from traditional risk factors such as diabetes mellitus, hypertension, and ischemic heart disease. This study also suggests constituting new reference values for this high risk population in stratifying patient risk and in assessing the intensity of appropriate treatment, with hopes of preventing cardiac deaths. MethodsIn this study, 200 patients (124 men and 76 women) who were hospitalized in the coronary care unit (CCU) with a diagnosis of ACS were included. All patients had normal serum GGT levels Abstract

show abstract

Section: Discussionsupporting

confidence: 88%

Prognostic Value of Serum Gamma-Glutamyltransferase, Calcium, and Inorganic Phosphorus Levels in Short-Term Mortality of Patients with Acute Coronary Syndrome

Ergen¹,

Erdenen²,

Müderrisoğlu³

et al. 2015

Istanbul Med J

View full text Add to dashboard Cite

show abstract

“…This finding triggered the studies focusing on the usefulness of GGT as a predictor of cardiovascular diseases. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] For the time being, this laboratory test has been searched by many groups regarding its suitability as a significant predictor for cardiometabolic diseases. Serum GGT was found to be a risk factor for cardiovascular mortality by the Vorarlberg Health Monitoring and Promotion Program Study Group.…”

Section: Discussionmentioning

confidence: 99%

“…[2] Recent studies have reported that serum GGT, which is an inexpensive and easily accessible laboratory test, is a predictor for incident cardiovascular diseases, and is associated with prognosis in cardiopulmonary disorders such as coronary artery disease, acute myocardial infarction, HF, and acute pulmonary embolism. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] However, the prognostic significance of GGT in patients presenting with acute coronary syndrome (ACS) with left ventricular systolic dysfunction (LVSD) has not been searched yet. We hypothesized that increased admission serum GGT activity may be associated with future acute HF in ACS patients with LVSD.…”

mentioning

confidence: 99%

Usefulness of admission gamma-glutamyltransferase level for predicting new-onset heart failure in patients with acute coronary syndrome with left ventricular systolic dysfunction

Sarıkaya

Aydın

Yücel

et al. 2014

Arch Turk Soc Cardiol

View full text Add to dashboard Cite

show abstract

“…One prior study reported that serum GGT predicted LV dilation and dysfunction in 40 patients with acute myocardial infarction. 17 To the best of our knowledge, our study is the first to demonstrate an association between serum GGT levels and the prevalence of LV diastolic dysfunction and LVH in a large cohort of adults without prior evidence of heart disease.…”

Section: Study Limitationsmentioning

confidence: 58%

“…Only one study found that serum GGT predicted LV dilation and dysfunction in 40 patients with acute myocardial infarction. 17 To date, the relationship between serum GGT levels and LV function has not been studied using large cohorts of healthy adults.…”

mentioning

confidence: 99%

Relationship Between γ-Glutamyltransferase Levels and Left Ventricular Diastolic Dysfunction

Ryu

Chang

Kang

et al. 2017

Circ J

View full text Add to dashboard Cite

tions with many cardiovascular disease (CVD) risk factors, as well as future risks of diabetes, chronic kidney disease, coronary artery disease (CAD), HF, stroke, and CVD mortality. 12-16 Therefore, it can be hypothesized that high levels of serum GGT may play a potential role in the development of subclinical LV diastolic dysfunction and LVH. Studies of subclinical HF can provide valuable information on clinical HF outcomes, particularly regarding the early stages of HF free from confounding secondary processes such as chronic liver damage. Only one study found that serum GGT predicted LV dilation and dysfunction in 40 patients with acute myocardial infarction. 17 To date, the relationship between serum GGT levels and LV function has not been studied using large cohorts of healthy adults. Heart failure (HF) is a major public health problem associated with high morbidity, mortality and healthcare expenditure. 1-3 Previous studies have demonstrated that subclinical left ventricular (LV) diastolic dysfunction and LV hypertrophy (LVH) predict the development of clinical HF. 4-6 Furthermore, LV diastolic dysfunction is associated with increased risk of sudden death, and the presence of LVH is a strong independent risk factor for future cardiac events and all-cause mortality. 7,8 Because of the serious consequences of overt HF, there is substantial interest in developing strategies and identifying potential risk factors to prevent or reduce the progression of LV dysfunction and hypertrophy.Serum γ -glutamyltransferase (GGT) has been widely used as an index of alcohol intake and liver dysfunction. 9,10 Recently, serum GGT was proposed as a sensitive marker of oxidative stress, 11 because it has dose-response associa- Editorial p 783Received October 26, 2016; revised manuscript received January 10, 2017; accepted January 23, 2017; released online Background: The goal of this study was to examine the association of serum γ -glutamyltransferase (GGT) levels with left ventricular (LV) diastolic dysfunction and LV hypertrophy.

show abstract

Is γ-glutamyl Transferase Activity a Potential Marker of Left Ventricular Function During Early Postmyocardial Infarction period?

Abstract: GGT is associated with oxidative/inflammatory markers and LV diastolic diameter suggesting its potential role in predicting LV dilatation and dysfunction during the early postmyocardial infarction period.

Cited by 6 publications

References 46 publications

Prognostic Value of Serum Gamma-Glutamyltransferase, Calcium, and Inorganic Phosphorus Levels in Short-Term Mortality of Patients with Acute Coronary Syndrome

Prognostic Value of Serum Gamma-Glutamyltransferase, Calcium, and Inorganic Phosphorus Levels in Short-Term Mortality of Patients with Acute Coronary Syndrome

Usefulness of admission gamma-glutamyltransferase level for predicting new-onset heart failure in patients with acute coronary syndrome with left ventricular systolic dysfunction

Relationship Between γ-Glutamyltransferase Levels and Left Ventricular Diastolic Dysfunction

Contact Info

Product

Resources

About