Introduction:Posttraumatic stress disorder (PTSD) is a psychiatric condition that can develop after experiencing or witnessing a traumatic event, and it is associated with a range of functional and structural brain abnormalities. The present study aimed to investigate age-related differences in subcortical grey matter and corresponding white matter in veterans with PTSD.
Material and methods: This study recruited 14 Iran-Iraq war veterans with PTSD, 30 war veterans in Syria with PTSD, and 48 healthy controls. Participants were divided into two age groups to evaluate age-specific alterations in brain regions using structural MRI analysis.
Result: The results showed that individuals with PTSD had significantly smaller subcortical gray matter volumes, including the bilateral thalamus, hippocampus, amygdala, left pallidum, and right accumbens-area (p < 0.05). DTI analyses revealed lower fractional anisotropy in several white matter structures, including the anterior limb of the internal capsule, anterior corona radiata, and cingulum in both hemispheres (p < 0.05). Additionally, the mean diffusivity was higher in the anterior limb of the internal capsule, anterior corona radiata, and cingulum in both hemispheres and the right external capsule (p < 0.05) in individuals with PTSD. Age-specific alterations were also observed in brain regions between the two age groups.
Conclusion:These findings suggest that PTSD is associated with significant structural and functional alterations in the brain, which may contribute to the pathophysiology of the disorder. So, age is a critical factor in exposure to traumatic events. Our results contribute to our understanding of the underlying mechanisms involved in PTSD and could potentially lead to the development of more targeted interventions for individuals with PTSD.