Is wheel running a re-directed stereotypic behaviour in striped mice Rhabdomys dilectus?

Joshi, Sneha; Pillay, Neville

doi:10.1016/j.applanim.2018.04.011

Cited by 5 publications

(5 citation statements)

References 46 publications

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“…Wheel running behavior could in addition to the addictive implications represent a type of stereotypic behavior in mice [28,34,[36][37][38]. Recently, Mason and Würbel suggested that wheel running may model exercise addiction rather than normal exercise behavior [38].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Mason and Würbel suggested that wheel running may model exercise addiction rather than normal exercise behavior [38]. Stereotypic striped mice used running wheels to redirect their stereotypic behavior [37]. In addition, wheel running seems to fulfill the criteria for stereotypic behavior in mice [38].…”

Section: Discussionmentioning

confidence: 99%

“…Short fasting bouts can increase locomotor activity, whereas fasting of six hours or more reduces physical activity, which is linked to a torpor-like behavior (reduced metabolic state) [35]. Stress is known to increase wheel running activity compared to non-stressed mice [34], which might be a form of stereotypic behavior to alleviate stress [34,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

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Interplay between Learning and Voluntary Wheel Running in Male C57BL/6NCrl Mice

Niiranen

Stenbäck

Tulppo

et al. 2023

IJMS

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Exercise is shown to improve cognitive function in various human and animal studies. Laboratory mice are often used as a model to study the effects of physical activity and running wheels provide a voluntary and non-stressful form of exercise. The aim of the study was to analyze whether the cognitive state of a mouse is related to its wheel-running behavior. Twenty-two male C57BL/6NCrl mice (9.5 weeks old) were used in the study. The cognitive function of group-housed mice (n = 5–6/group) was first analyzed in the IntelliCage system followed by individual phenotyping with the PhenoMaster with access to a voluntary running wheel. The mice were divided into three groups according to their running wheel activity: low, average, and high runners. The learning trials in the IntelliCage showed that the high-runner mice exhibited a higher error rate at the beginning of learning trials but improved their outcome and learning performance more compared to the other groups. The high-runner mice ate more compared to the other groups in the PhenoMaster analyses. There were no differences in the corticosterone levels between the groups, indicating similar stress responses. Our results demonstrate that high-runner mice exhibit enhanced learning capabilities prior to access to voluntary running wheels. In addition, our results also show that individual mice react differently when introduced to running wheels, which should be taken into consideration when choosing animals for voluntary endurance exercise studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interplay between Learning and Voluntary Wheel Running in Male C57BL/6NCrl Mice

Niiranen

Stenbäck

Tulppo

et al. 2023

IJMS

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“…The frustration triggered by food restriction can initiate oral stereotypic behaviors in sows [ 32 ]. The expression of stereotypies has also been investigated in relation to some factors, such as the genetic component [ 33 , 34 ], personality predisposition [ 35 , 36 ], individual variation [ 37 ] and susceptibility in relation to sex [ 38 ]. Some environmental variables have more impact on the occurrence of stereotypies than others [ 39 ].…”

Section: Stereotypies As Animal Welfare Indicatorsmentioning

confidence: 99%

“…Some environmental variables have more impact on the occurrence of stereotypies than others [ 39 ]. The motor patterns of wheel-running in mice fit the concept of stereotypy, and this may help to explain the causation of other behaviors [ 37 ]. Regarding cognitive bias, mice with higher levels of stereotypic behavior made more optimistic choices [ 40 ].…”

Section: Stereotypies As Animal Welfare Indicatorsmentioning

confidence: 99%

Changes in Stereotypies: Effects over Time and over Generations

Tatemoto

Zanella

2022

Animals

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Stereotypies comprise a wide range of repeated and apparently functionless behaviors that develop in individuals whose neural condition or environment results in poor welfare. While stereotypies are an indicator of poor welfare at the time of occurrence, they may have various consequences. Environmental enrichment modifies causal factors and reduces the occurrence of stereotypies, providing evidence that stereotypies are an indicator of poor welfare. However, stereotypy occurrence and consequences change over time. Furthermore, there are complex direct and epigenetic effects when mother mammals that are kept in negative conditions do or do not show stereotypies. It is proposed that, when trying to deal with challenging situations, stereotypies might initially help animals to cope. After further time in the conditions, the performance of the stereotypy may impair brain function and change brain connections, neurophysiology and eventually neuroanatomy. It is possible that reported neuroanatomical changes are an effect of the stereotypy rather than a cause.

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Reduction of restricted repetitive behavior by environmental enrichment: Potential neurobiological mechanisms

Farmer

Lewis

2023

Neuroscience & Biobehavioral Reviews

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Is wheel running a re-directed stereotypic behaviour in striped mice Rhabdomys dilectus?

Cited by 5 publications

References 46 publications

Interplay between Learning and Voluntary Wheel Running in Male C57BL/6NCrl Mice

Interplay between Learning and Voluntary Wheel Running in Male C57BL/6NCrl Mice

Changes in Stereotypies: Effects over Time and over Generations

Reduction of restricted repetitive behavior by environmental enrichment: Potential neurobiological mechanisms

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