Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients?

Jatoi, Aminah; Williams, Brent A.; Nichols, Frank C.; Marks, Randolph S.; Aubry, Marie Christine; Wampfler, Jason A.; Finke, Erin E.; Yang, Ping

doi:10.1016/j.lungcan.2005.01.004

Cited by 36 publications

(28 citation statements)

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“…Even after introducing other variables of prognostic significance, such as age, tumor stage, tumor grade, smoking status at diagnosis, gender, and vitamin use as part of a multivariate analysis with a Cox model, there were still no statistically significant differences in survival among groups [9,10,11] (Fig. 1).…”

Section: Survival and Quality Of Lifementioning

confidence: 98%

Does Marital Status Impact Survival and Quality of Life in Patients with Non-Small Cell Lung Cancer? Observations from the Mayo Clinic Lung Cancer Cohort

et al. 2007

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Purpose. Previous studies have found that marriage is associated with longer survival and better quality of life among lung cancer patients. The present study used the Mayo Clinic Lung Cancer Cohort to re-examine this issue.Methods. In total, 5,898 non-small cell lung cancer (NSCLC) patients, who had available information on marital status and who had been enrolled in the Mayo Clinic Lung Cancer Cohort (MCLCC), were the focus of this study. Patients had extensive baseline and follow-up data on cancer stage, cancer treatment, and prognostic factors. All patients had been followed within the MCLCC with at least annual confirmation of vital status and patient-reported quality of life (the Lung Cancer Symptom Scale and the Linear Analogue Scales of Assessment).Results. The numbers of patients who were married, single, divorced, and widowed at the time of cancer diagnosis were 4,457 (76%), 265 (4%), 440 (7%), and 736 (12%), respectively. No statistically significant difference in survival was observed among these four groups, even after adjusting for a variety of prognostic factors, such as age, gender, and tumor stage. However, exploratory analyses suggested that widowed and divorced patients received less aggressive cancer therapy, and certain patient subgroups, such as stage IA widowed patients, had a shorter survival. Divorced patients reported greater financial concerns, and married and widowed patients reported greater spirituality and better social support.Conclusion. This study did not observe differences in survival or quality of life based on marital status at the time of diagnosis of NSCLC, but subgroup analyses appear to suggest findings worthy of further exploration.

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Section: Survival and Quality Of Lifementioning

confidence: 98%

Does Marital Status Impact Survival and Quality of Life in Patients with Non-Small Cell Lung Cancer? Observations from the Mayo Clinic Lung Cancer Cohort

et al. 2007

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“…The relevance of micronutrients as part of the supportive nutritional care of cancer patients is confirmed not least by the results of studies showing that the intake of micronutrient supplements can improve both the quality of life and the prognosis of tumor patients (38)(39)(40). Thus, in an observational study with lung cancer patients the risk of dying was 20% lower in the patients Table V.…”

Section: ------------------------------------------------------------mentioning

confidence: 86%

“…This is due to the fact that many cancer patients develop a tumor-associated malnutrition characterized by an insufficient supply of macro-and micronutrients (17-31). The inadequate nutrition status and the cancer anorexia-cachexia syndrome combined with it (15, [32][33][34] are clinically relevant because they not only diminish the response to antineoplastic measures, such as radiation and chemotherapy (35,36), but also aggravate their side effects and have a negative impact on the patient's quality of life and prognosis (14, [37][38][39][40][41][42][43]. Thus, an adequate nutritional intervention can have a beneficial influence on the progress of the disease and the patient's condition.…”

Section: Introductionmentioning

confidence: 99%

Nutrition in oncology: the case of micronutrients (Review)

Ströhle¹

2010

Oncol Rep

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Abstract. In the course of cancer disease, many oncological patients develop tumor-associated malnutrition characterized by an insufficient supply of macro-and micronutrients. The inadequate nutritional status and the cancer anorexia-cachexia syndrome related to it are clinically relevant, as the response to antineoplastic measures, such as radiation and chemotherapy, is diminished, their side effects aggravated and the patient's quality of life and prognosis negatively affected. Therefore, the supportive nutrition care of oncological patients is of central importance. In this context, vitamins, minerals and long-chain ˆ-3 fatty acids are becoming more and more relevant in oncology although the benefit of such supplements is discussed controversially. Starting from a description of the etiopathogenesis and the pathophysiological consequences of cancer-associated malnutrition, the present study provides an overview of the importance of micronutrients for oncological patients. In the case of reduced food intake and/or inappropriate food choice the use of a multi-vitaminmultimineral supplement administered in physiological doses, i.e. nutrient quantities approximately corresponding to the recommended daily allowances, can be generally recommended. However, to enhance postoperative wound healing, it seems that cancer patients require higher amounts of micronutrients than healthy individuals. Because vitamin D deficiency is highly prevalent in oncological patients, improvement of vitamin D status is of special interest.

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“…[35][36][37] In a small crosssectional study a random selection (n 5 36) of postoperative nonsmall cell lung cancer patients were invited to complete a food frequency questionnaire and donate a blood sample. 35 The vitamin-users had significantly longer median disease-free survival at the time of the study compared with nonusers, 41 vs. 11 months (p 5 0.002).…”

Section: Discussionmentioning

confidence: 99%

“…The second study was a prospective study of nonsmall cell lung cancer patients in the Mayo Clinic lung cancer cohort. 36 The 1,129 participants received a supplement questionnaire 6 months after diagnosis, and later at regular intervals. The relative risk of death was 0.54 (95% CI 0.44-0.65) among current users compared to non-users.…”

Section: Discussionmentioning

confidence: 99%

Cod liver oil, other dietary supplements and survival among cancer patients with solid tumours

Skeie

Br̈aaten

Hjartåker

et al. 2009

Intl Journal of Cancer

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The effect of various dietary supplements on chronic diseases and mortality has been widely studied, but few convincing results have emerged from studies in well-nourished populations. In Norway, both cod liver oil and other dietary supplements are frequently used. In the Norwegian Women and Cancer cohort study, we explored if supplement use before diagnosis affected survival of cancer patients with solid tumours. We performed Cox proportional hazards analyses, adjusting for age at diagnosis, smoking and stage. Cod liver oil was the most frequently used dietary supplement, followed by multivitamins and -minerals. Whole year daily use of cod liver oil was associated with lower risk of death in patients with solid tumours 1 Dietary supplements comprise a wide range of products of differing composition. Studies of their effects on primary prevention of chronic diseases, as well as mortality, have generally failed to demonstrate beneficial effects in well-nourished populations. 2-7Clinical trials have also been stopped early due to no preventive effects and suggestions of negative health effects, a recent example is the SELECT study. 8 The second WCRF/AICR expert report summarized that there is not enough evidence yet for giving specific advice to cancer survivors, neither on supplement use nor on other dietary factors. They, therefore, suggest that survivors follow general cancer preventive advice, which is not taking supplements, but try to meet nutritional needs through diet alone. 6 The American Cancer Society has developed guidelines for nutrition and physical activity during and after cancer treatment, even though they know that the scientific evidence is incomplete. During and after cancer treatment, a standard multiple vitamin and mineral supplement containing approximately 100% of the daily value is recommended, since it might be difficult to eat a diet with adequate amounts of micronutrients in those times. However, no evidence was found to suggest that nutritional supplements lower risk of recurrence. Use of high-dose supplements is discouraged. 9There is some concern that high-dose antioxidant supplements might interfere with radio-or chemotherapy treatments, though this is somewhat controversial. 9,10Dietary supplement use is common in Norway, and the most commonly taken dietary supplement is cod liver oil (CLO). 11-14Typically 35% of the female adult population takes it daily at least during winter. Also other supplements are taken frequently and 40-60% of Norwegian women report use of other supplements.11,15 Compared with healthy women, Norwegian breast cancer survivors did not have a significantly higher consumption of CLO, but used other dietary supplements at a higher frequency. 16 The difference was limited to those surveyed rather shortly (1-5 years) after diagnosis.CLO is the second most important dietary source of very-longchain fatty acids in the Norwegian diet (after fish) and women in the highest quartile of very-long-chain fatty acid intake have a more than tripled intake of vitamin D comp...

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Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients?

Cited by 36 publications

References 13 publications

Does Marital Status Impact Survival and Quality of Life in Patients with Non-Small Cell Lung Cancer? Observations from the Mayo Clinic Lung Cancer Cohort

Does Marital Status Impact Survival and Quality of Life in Patients with Non-Small Cell Lung Cancer? Observations from the Mayo Clinic Lung Cancer Cohort

Nutrition in oncology: the case of micronutrients (Review)

Cod liver oil, other dietary supplements and survival among cancer patients with solid tumours

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