Is vitamin D deficiency influenced by obesity during the first 5 years of life? A cross‐sectional multicenter study

Abstract

Evidence on the association of 25‐hydroxyvitamin D (25[OH]D) and obesity during the first 5 years of life is limited in China. The objective of this study was to examine the associations between weight, weight for age z score (ZWAZ), weight for length/height z score (ZWHZ), and body mass index for age z score (ZBMI) and 25(OH)D. This was a large population‐based cross‐sectional multicenter study in which the children aged 0–5 years were recruited from 12 children's healthcare centers by a stratified cluster random‐sampling method in 10 cities of the Jiangsu province, China. The 25(OH)D concentration was determined by ELISA. A total of 5289 children were investigated. For 0–71 months children with obesity and nonobesity, the prevalence of vitamin D deficiency was 36.0% and 29.8%, and the 25(OH)D level was 59.8 and 64.0 nmol/L, respectively, and there were all significant difference. Compared with children with nonobesity, children with obesity had higher risk of vitamin D deficiency (OR [95% CI]: 1.33 [1.02, 1.72], p < .05), and had lower 25(OH)D level (β = −3.84, 95% CI = −7.58, −0.09, p < .05). The results for children aged 24–71 months were similar to those for children aged 0–71 months. However, no significant difference was observed in children aged 0–23 months. Vitamin D deficiency was observed in children with greater adiposity during the first 5 years of life. However, the results mainly came from those in the age group of 2 to 5 years instead of the first 2 years in their lives.

Expression profile of tsRNAs in white adipose tissue of vitamin D deficiency young male mice with or without obesity

“…In our previous study, vitamin D de ciency was observed in children with greater adiposity during the rst 5 years of life (5). However, the mehcanism has not been well-de ned.…”

“…Our previous study was a large population-based cross-sectional multicenter study in which 5289 children aged 0-5 years were recruited from 12 Children's Health Care Centers by a strati ed cluster random-sampling method in 10 cities of Jiangsu Province, China. The results showed that the prevalence of VD de ciency in 0-5 years children was 30.1% (4), and the prevalence of VD de ciency in 0-5 years children with obesity and non-obesity was 36.0%, 29.8%, respectively, there were all signi cant difference (5). Vitamin D de ciency was observed in children with greater adiposity during the rst 5 years of life.…”