Is vitamin D deficiency correlated with childhood wheezing and asthma

Comberiati, Pasquale; Tsabouri, Sophia; Piacentini, Giorgio; Moser, Serena; Minniti, Federica; Peroni, Diego

doi:10.2741/e687

Cited by 16 publications

(7 citation statements)

References 49 publications

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“…Studies have shown that vitamin D plays a role in fetal lung development and maturation as well as maintaining lung structure and function (reviewed in 25 ). In a rat model aimed at determining the effects of perinatal vitamin D deficiency on pulmonary function, females were put on a special diet (no cholecalciferol or a 250, 500 or 1,000 IU/kg cholecalciferol) one month before pregnancy, which was continued throughout pregnancy and lactation.…”

Section: Results From Animal Studiesmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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Section: Results From Animal Studiesmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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“…In some studies lower levels of vitamin D has been found in asthmatic patients that leads to decline in airway functions [27,28]. Vitamin D supplementation in asthmatic patients can reduce the severity of the disease and can enhance airway responsiveness to glucocorticoids [29]. However, some other studies did not find an association between vitamin D and the airways function [30,31].…”

Section: Introductionmentioning

confidence: 99%

Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study

2020

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Background Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated. Methods This was a case–control study performed in 2015 in the city of Isfahan. In this study 520 children were studied. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared between the two groups. Differences among groups were stated to be statistically significant when P-values < 0.05. Results There were 260 asthmatic children and 260 controls in the present study. The mean 25 (OH) vit. D levels in the case group was 25.5 ± 16.62 and 16.76 ± 31.40 the control group and this difference was statistically significant (P < 0.05). 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. Consequently 25(OH) vit. D level had inverse relationship with asthma severity (P = 0.002). Conclusions As the results of this study showed, the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. Therefore, it is recommended that 25(OH) vit. D levels get routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures be used to reduce the asthma severity.

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“…table 1). Several potential mechanisms for the programming of allergy by maternal vitamin D status were described in a recent review [105], relating it to both the innate and adaptive immune system (further described in online suppl. table 1).…”

Section: Pregnancy Diet and Nutritional Interventionsmentioning

confidence: 99%

In utero Programming of Allergic Susceptibility

Grieger

Clifton

Tuck

et al. 2016

Int Arch Allergy Immunol

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Background: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions.

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Is vitamin D deficiency correlated with childhood wheezing and asthma

Cited by 16 publications

References 49 publications

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Association of 25-hydroxy vitamin D with asthma and its severity in children: a case–control study

In utero Programming of Allergic Susceptibility

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