“…In their study, fever was 250 observed more frequently in patients with VL than those with VL/HIV co-infection, [23,28]. Different 254 from many Brazilian studies, which reported the presence of splenomegaly followed by 255 fever, weight loss, and asthenia, in 81 patients with VL/HIV co-infection in Ceará [29] 256 and another study that identified weight loss, weakness, fever, and hepatosplenomegaly 257 as the most common physical changes in 65 patients with VL/HIV co-infection [13], the 258 most common symptoms in this study were skin pallor, hepatomegaly, and levels observed in some patients with VL/HIV co-infection [33,34,35] was also found in 279 the present study. However, we should note that such an increase was higher in patients 280 with VL alone, as additionally reported by De Souza et al and Cota et al [25,36].…”